文献

J-GLOBAL ID：201802281058949127   整理番号：18A1197197

鼻遺伝子発現は,COPDを制御し,気管支遺伝子発現を重複させる【JST・京大機械翻訳】

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

著者 (40件)： Boudewijn Ilse M. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Boudewijn Ilse M. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Faiz Alen (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Faiz Alen (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Steiling Katrina (Division of Computational Biomedicine, Boston University School of Medicine, Boston, USA) ,  Steiling Katrina (Bioinformatics Program, Boston University, Boston, USA) ,  Wiel Erica van der (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Wiel Erica van der (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Telenga Eef D. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Telenga Eef D. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Hoonhorst Susan J. M. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Hoonhorst Susan J. M. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Hacken Nick H. T. ten (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Hacken Nick H. T. ten (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Brandsma Corry-Anke (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Brandsma Corry-Anke (University of Groningen, University Medical Center Groningen, Department of Pathology, section Medical Biology, Groningen, the Netherlands) ,  Kerstjens Huib A. M. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Kerstjens Huib A. M. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Timens Wim (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Timens Wim (University of Groningen, University Medical Center Groningen, Department of Pathology, section Medical Biology, Groningen, the Netherlands) ,  Heijink Irene H. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Heijink Irene H. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Heijink Irene H. (University of Groningen, University Medical Center Groningen, Department of Pathology, section Medical Biology, Groningen, the Netherlands) ,  Jonker Marnix R. (University of Groningen, University Medical Center Groningen, Department of Pathology, section Medical Biology, Groningen, the Netherlands) ,  Bruin Harold G. de (University of Groningen, University Medical Center Groningen, Department of Pathology, section Medical Biology, Groningen, the Netherlands) ,  Vroegop J. Sebastiaan (Martini Hospital, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Pasma Henk R. (Medical Center Leeuwarden, Department of Pulmonary Diseases, Leeuwarden, the Netherlands) ,  Boersma Wim G. (Noordwest Ziekenhuisgroep, Department of Pulmonary Diseases, Alkmaar, the Netherlands) ,  Wielders Pascal (Catharina Hospital, Department of Pulmonary Diseases, Eindhoven, the Netherlands) ,  Elshout Frank van den (Rijnstate Hospital, Department of Pulmonary Diseases, Arnhem, the Netherlands) ,  Mansour Khaled (Orbis Concern, Department of Pulmonary Diseases, Sittard, the Netherlands) ,  Spira Avrum (Division of Computational Biomedicine, Boston University School of Medicine, Boston, USA) ,  Spira Avrum (Bioinformatics Program, Boston University, Boston, USA) ,  Lenburg Marc E. (Division of Computational Biomedicine, Boston University School of Medicine, Boston, USA) ,  Lenburg Marc E. (Bioinformatics Program, Boston University, Boston, USA) ,  Guryev Victor (European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands) ,  Postma Dirkje S. (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Postma Dirkje S. (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands) ,  Berge Maarten van den (University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands) ,  Berge Maarten van den (University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands)
資料名： Respiratory Research (Web)  (Respiratory Research (Web))
巻： 18  号： 1  ページ： 213  発行年： 2017年 
JST資料番号： U7545A  ISSN： 1465-993X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 鼻遺伝子発現プロファイリングはCOPDを非侵襲的に特性化する有望な方法である。健常対照者とCOPD患者を区別するために,鼻遺伝子発現プロファイルを同定することを目的とした。著者らは,鼻上皮におけるこのCOPD関連遺伝子発現プロファイルが気管支上皮で観察されたプロファイルと同等であるかどうかを調べた。31人の重症COPD患者と22人の対照者の鼻上皮ブラシについてゲノムワイド遺伝子発現分析を行い,全ての現在の喫煙者はAffymetrix Human Gene 1.0 ST Arrayを用いた。軽度から中等度のCOPD患者と対照の2つの独立したコホートにおいて,気管支上皮ブラシに関する遺伝子発現分析を繰り返した。鼻上皮において,135の遺伝子は,重度のCOPD患者と対照の間で有意に差別的に発現して,21は,COPD(偽発見比率<0.01)において下方制御した。遺伝子セット濃縮分析(GSEA)は,両独立コホート(FDRGSEA<0.001)において,COPD関連鼻および気管支遺伝子発現の有意な一致した濃縮を示した。対照から重症COPD患者を区別する鼻遺伝子発現プロファイルを同定した。興味深いことに,COPDにおける鼻遺伝子発現変化の一部は,気管支において異なる発現遺伝子を模倣する。これらの知見は,鼻遺伝子発現プロファイリングが,COPD.ClinicalTrials.gov登録番号NCT01351792(登録日5月10日,2009年),ClinicalTrials.gov登録番号NCT00807469(登録日11,2008)の非侵襲的バイオマーカーとして有用であることを示している。Copyright 2018 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ブラシ ,  *慢性閉塞性肺疾患 ,  ダウンレギュレーション ,  キャラクタリゼーション ,  *遺伝子 ,  母集団 ,  患者 ,  *遺伝子発現 ,  バイオマーカー ,  上皮 ,  *気管支
準シソーラス用語： 喫煙者 ,  重症 ,  非侵襲 ,  遺伝子発現プロファイリング , 【Automatic Indexing@JST】

著者キーワード (5件)： COPD ,  鼻上皮 ,  気管支上皮 ,  ゲノムワイド遺伝子発現 ,  マイクロアレイ

分類 (1件)： 遺伝子発現  (EC02040Q)

引用文献 (43件)：

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タイトルに関連する用語 (4件)： 鼻 ,  遺伝子発現 ,  COPD ,  気管支