文献

J-GLOBAL ID：201802281806851725   整理番号：18A1022764

結腸癌の分類のためのコンセンサス免疫コアの国際的検証:予後と精度研究【JST・京大機械翻訳】

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

著者 (120件)： Pages Franck (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Pages Franck (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Pages Franck (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Pages Franck (Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Mlecnik Bernhard (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Mlecnik Bernhard (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Mlecnik Bernhard (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Mlecnik Bernhard (Inovarion, Paris, France) ,  Marliot Florence (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Marliot Florence (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Marliot Florence (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Marliot Florence (Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Bindea Gabriela (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Bindea Gabriela (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Bindea Gabriela (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Ou Fang-Shu (Cancer Center Statistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA) ,  Bifulco Carlo (Department of Pathology, Providence Portland Medical Center, Portland, OR, USA) ,  Lugli Alessandro (Institute of Pathology, University of Bern, Bern, Switzerland) ,  Zlobec Inti (Institute of Pathology, University of Bern, Bern, Switzerland) ,  Rau Tilman T (Institute of Pathology, University of Bern, Bern, Switzerland) ,  Berger Martin D (Department of Medical Oncology, University Hospital of Bern, Bern, Switzerland) ,  Nagtegaal Iris D (Pathology Department, Radboud University, Nijmegen, Netherlands) ,  Vink-Borger Elisa (Pathology Department, Radboud University, Nijmegen, Netherlands) ,  Hartmann Arndt (Department of Pathology, University Erlangen-Nuernberg, Erlangen, Germany) ,  Geppert Carol (Department of Pathology, University Erlangen-Nuernberg, Erlangen, Germany) ,  Kolwelter Julie (Department of Pathology, University Erlangen-Nuernberg, Erlangen, Germany) ,  Merkel Susanne (Department of Surgery, University Erlangen-Nuernberg, Erlangen, Germany) ,  Gruetzmann Robert (Department of Surgery, University Erlangen-Nuernberg, Erlangen, Germany) ,  Van den Eynde Marc (Institut Roi Albert II, Department of Medical Oncology Cliniques Universitaires St-Luc, Brussels, Belgium) ,  Van den Eynde Marc (Institut de Recherche Clinique et Experimentale (Pole MIRO), Universite Catholique de Louvain, Brussels, Belgium) ,  Jouret-Mourin Anne (Department of Pathology, Cliniques Universitaires St-Luc, Brussels, Belgium) ,  Jouret-Mourin Anne (Institut de Recherche Clinique et Experimentale (Pole GAEN), Universite Catholique de Louvain, Brussels, Belgium) ,  Kartheuser Alex (Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Universite Catholique de Louvain, Brussels, Belgium) ,  Leonard Daniel (Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Universite Catholique de Louvain, Brussels, Belgium) ,  Remue Christophe (Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Universite Catholique de Louvain, Brussels, Belgium) ,  Wang Julia Y (Curandis Laboratories, Boston, MA, USA) ,  Wang Julia Y (Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada) ,  Wang Julia Y (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada) ,  Bavi Prashant (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada) ,  Roehrl Michael H A (Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada) ,  Roehrl Michael H A (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada) ,  Roehrl Michael H A (Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Ohashi Pamela S (University Health Network, Toronto, ON, Canada) ,  Nguyen Linh T (University Health Network, Toronto, ON, Canada) ,  Han SeongJun (University Health Network, Toronto, ON, Canada) ,  MacGregor Heather L (University Health Network, Toronto, ON, Canada) ,  Hafezi-Bakhtiari Sara (Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada) ,  Wouters Bradly G (University Health Network, Toronto, ON, Canada) ,  Masucci Giuseppe V (Department of Oncology-Pathology, Karolinska Institutet, Karolinska University, Stockholm, Sweden) ,  Andersson Emilia K (Department of Oncology-Pathology, Karolinska Institutet, Karolinska University, Stockholm, Sweden) ,  Zavadova Eva (Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic) ,  Vocka Michal (Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic) ,  Spacek Jan (Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic) ,  Petruzelka Lubos (Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic) ,  Konopasek Bohuslav (Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic) ,  Dundr Pavel (Institute of Pathology, First Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Dundr Pavel (General University Hospital in Prague, Prague, Czech Republic) ,  Skalova Helena (Institute of Pathology, First Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Skalova Helena (General University Hospital in Prague, Prague, Czech Republic) ,  Nemejcova Kristyna (Institute of Pathology, First Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Nemejcova Kristyna (General University Hospital in Prague, Prague, Czech Republic) ,  Botti Gerardo (Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione G.Pascale” Naples, Italy) ,  Tatangelo Fabiana (Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione G.Pascale” Naples, Italy) ,  Delrio Paolo (Colorectal Surgery Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione G.Pascale” Naples, Italy) ,  Ciliberto Gennaro (IRCCS Istituto Nazionale Tumori “Regina Elena”, Rome, Italy) ,  Maio Michele (Center for Immuno-Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy) ,  Laghi Luigi (Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy) ,  Grizzi Fabio (Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy) ,  Grizzi Fabio (Humanitas University, Rozzano, Milan, Italy) ,  Fredriksen Tessa (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Fredriksen Tessa (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Fredriksen Tessa (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Buttard Benedicte (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Buttard Benedicte (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Buttard Benedicte (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Angelova Mihaela (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Angelova Mihaela (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Angelova Mihaela (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Vasaturo Angela (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Vasaturo Angela (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Vasaturo Angela (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Maby Pauline (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Maby Pauline (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Maby Pauline (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Church Sarah E (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Church Sarah E (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Church Sarah E (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Church Sarah E (NanoString Technologies, Seattle, WA, USA) ,  Angell Helen K (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Angell Helen K (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Angell Helen K (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Angell Helen K (Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK) ,  Lafontaine Lucie (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Lafontaine Lucie (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Lafontaine Lucie (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Bruni Daniela (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Bruni Daniela (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Bruni Daniela (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  El Sissy Carine (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  El Sissy Carine (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  El Sissy Carine (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  El Sissy Carine (Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Haicheur Nacilla (Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Kirilovsky Amos (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Kirilovsky Amos (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Kirilovsky Amos (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Kirilovsky Amos (Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Berger Anne (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Berger Anne (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Berger Anne (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Berger Anne (Digestive Surgery Department, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Lagorce Christine (INSERM, Laboratory of Integrative Cancer Immunology, Paris, France) ,  Lagorce Christine (Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Lagorce Christine (Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Sorbonne Universites, Paris, France) ,  Lagorce Christine (Digestive Surgery Department, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France) ,  Meyers Jeffrey P (Cancer Center Statistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA) ,  Paustian Christopher (Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA) ,  Feng Zipei (Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA) ,  Ballesteros-Merino Carmen (Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA) ,  Dijkstra Jeroen (Pathology Department, Radboud University, Nijmegen, Netherlands)
資料名： Lancet  (Lancet)
巻： 391  号： 10135  ページ： 2128-2139  発行年： 2018年 
JST資料番号： B0673A  ISSN： 0140-6736  CODEN： LANCA  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 結腸癌患者に対する再発リスクの評価は改善されなければならない。癌分類に免疫パラメータを導入するためには,ロバストな免疫スコア定量化が必要である。本研究の目的は,ステージI~III結腸癌患者における総腫瘍浸潤T細胞数と細胞毒性腫瘍浸潤T細胞数の予後的価値を評価することであった。癌の免疫療法のための学会によってもたらされた13の国における14のセンターの国際共同体は,TNMステージI-III結腸癌患者における免疫学的検査を評価した。患者を無作為に訓練セット,内部検証セット,または外部検証セットに割り当てた。結腸腫瘍のパラフィン切片および各患者からの浸潤縁を免疫組織化学により処理し,腫瘍および浸潤縁におけるCD3+および細胞毒性CD8+T細胞の密度を,デジタル病理学により定量した。各患者に対する免疫原性は,4つの密度パーセンタイルの平均から誘導された。一次エンドポイントは,手術から疾患再発までの時間として定義された再発までの時間に対する免疫原性の予後的価値を評価することであった。層別化した多変量Coxモデルを用いて,潜在的交絡因子に対して調整して,免疫振動と結果の間の関連性を評価した。HarrellのC統計を用いてモデル性能を評価した。3539人の患者からの組織サンプルを処理し,2681人の患者からのサンプルを,品質管理(訓練セットの700人の患者,内部検証セットの636人の患者と外部検証セットの1345人の患者)の後の分析に含めた。免疫蛍光分析は,観察者とセンターの間の再現性の高いレベルを示した(結腸腫瘍に対するr=0 97,浸潤マージンに対するr=0 97,p<0 ・ 0001)。訓練セットにおいて,高い免疫原性を有する患者は,5年における再発の最低リスクを有していた(14[8%])患者は,低い免疫原性を有する65人(19%)の患者で,高い対低い免疫原性0,95%CI0,10-0,p<0 0001)を示した。これらの知見は2つの検証セット(n=1981)で確認された。層別化Cox多変量解析において,再発までの時間との免疫学的相関は,患者年齢,性別,Tステージ,Nステージ,マイクロサテライト不安定性,および既存の予後因子(p<0 ・0001)とは独立していた。ステージII癌の1434名の患者のうち,5年での再発リスクの差は,Cox多変量解析(p<0 ・0001)を含む,有意(高い対低い免疫原性0 33,95% CI 0 21-0 ・52;p<0 ・ 0001)であった。免疫オシロは,国際癌管理TNM分類システムに対する癌と連合に関する米国共同委員会を含むすべての臨床パラメータのリスクに対して最も高い相対的寄与を有していた。免疫オシロは,結腸癌患者における再発リスクの信頼できる推定を提供する。これらの結果は,癌のTNM免疫分類の新しい成分としてのコンセンサス免疫学の実施を支持する。フランス国立衛生研究所では,LabEx免疫腫瘍学,Transscan ERANET免疫学,欧州プロジェクト,CARPEM,AP-HP,国立癌,癌研究のためのイタリア協会,癌の免疫療法のための国立grアリと学会を紹介した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *結腸腫瘍 ,  イタリア共和国 ,  細胞毒性 ,  アメリカ合衆国 ,  再現性 ,  腫瘍浸潤 ,  再発 ,  免疫原性 ,  多変量解析 ,  免疫療法 ,  免疫組織化学 ,  病理学 ,  浸潤 ,  患者 ,  T細胞

分類 (1件)： 消化器の腫よう  (GH04000D)

タイトルに関連する用語 (8件)： 結腸癌 ,  分類 ,  コンセンサス ,  免疫 ,  コア ,  検証 ,  予後 ,  研究