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J-GLOBAL ID：201802281957549796   整理番号：18A0819967

YY1は胚幹細胞におけるBAF複合体を介してプロモーターとスーパーエンハンサーを標的とすることにより転写を正に制御する【JST・京大機械翻訳】

YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

著者 (52件)： Wang Jia (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Wang Jia (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wang Jia (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wu Xingui (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Wu Xingui (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wu Xingui (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wei Chao (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Wei Chao (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wei Chao (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Huang Xin (The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Huang Xin (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Ma Qian (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Ma Qian (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Ma Qian (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Huang Xiaona (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Huang Xiaona (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Huang Xiaona (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Faiola Francesco (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) ,  Faiola Francesco (College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China) ,  Guallar Diana (Centro de Investigacionen Medicina Molecular e EnfermidadesCronicas, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain) ,  Fidalgo Miguel (Centro de Investigacionen Medicina Molecular e EnfermidadesCronicas, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain) ,  Huang Tingyuan (Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China) ,  Peng Di (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China) ,  Chen Li (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China) ,  Yu Haopeng (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Yu Haopeng (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Yu Haopeng (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Li Xingyu (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Li Xingyu (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Li Xingyu (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Sun Junyi (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Sun Junyi (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Sun Junyi (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Liu Xinyi (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Liu Xinyi (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Liu Xinyi (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Cai Xiaoxia (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Cai Xiaoxia (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Cai Xiaoxia (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Chen Xiao (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Chen Xiao (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Chen Xiao (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wang Ling (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Wang Ling (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Wang Ling (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China) ,  Ren Jian (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China) ,  Wang Jianlong (The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Wang Jianlong (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Wang Jianlong (The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Ding Junjun (Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China) ,  Ding Junjun (Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China) ,  Ding Junjun (Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China)
資料名： Stem Cell Reports  (Stem Cell Reports)
巻： 10  号： 4  ページ： 1324-1339  発行年： 2018年 
JST資料番号： W3132A  ISSN： 2213-6711  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： yin Yang1(YY1)は初期の胚発生と成体組織形成を調節する。しかしながら,幹細胞調節におけるYY1の役割は不明のままである。YY1は哺乳類細胞においてポリコーム群(PcG)蛋白質依存性役割を有する。YY1のPcG非依存性機能も報告されているが,それらの基礎となる機構はまだ明らかにされていない。本論文は,マウス胚性幹細胞(mESC)におけるOCT4仲介多能性ネットワークにおけるYY1とBAF複合体の役割を報告する。YY1とBAF複合体の間の相互作用は,mESC増殖と多能性を促進する。BAF複合体のコア成分であるYy1またはSmarca4のノックダウンは,多能性マーカーを下方制御し,いくつかの分化マーカーをアップレギュレーションする。さらに,YY1は転写を刺激するためにプロモーターとスーパーエンハンサー領域の両方で濃縮する。したがって,本研究は,OCT4とBAF複合体との相互作用を通しての多能性の調節におけるYY1の役割と,YY1をコア多能性ネットワークへの統合におけるBAF複合体の役割を明らかにする。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 胚発生 ,  タンパク質 ,  *複合体 ,  エンハンサー領域 ,  成体 ,  ダウンレギュレーション ,  汎用性 ,  細胞周期 ,  アップレギュレーション ,  ネットワーク ,  *幹細胞 ,  相互作用 ,  *プロモーター領域 ,  *ES細胞
準シソーラス用語： *YY1転写因子 , 【Automatic Indexing@JST】

著者キーワード (8件)： YY1 ,  polycomb ,  BAF複合体 ,  スーパーエンハンサー ,  多能性 ,  OCT4 ,  インタラクトーム ,  細胞周期

分類 (2件)： 遺伝子発現  (EC02040Q) ,  生物学的機能  (EB03040U)

タイトルに関連する用語 (8件)： YY1 ,  胚幹細胞 ,  BAF ,  複合体 ,  プロモーター ,  スーパーエンハンサー ,  標的 ,  転写