文献

J-GLOBAL ID：201802282322334520   整理番号：18A1429350

精神細胞地図イニシアチブ:神経精神疾患における重要な分子経路を明らかにするための収束系生物学的アプローチ【JST・京大機械翻訳】

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders

著者 (74件)： Willsey A. Jeremy (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Willsey A. Jeremy (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Willsey A. Jeremy (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Morris Montana T. (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Wang Sheng (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Willsey Helen R. (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Sun Nawei (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Teerikorpi Nia (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Teerikorpi Nia (Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Baum Tierney B. (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Cagney Gerard (School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland) ,  Bender Kevin J. (Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Desai Tejal A. (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Desai Tejal A. (Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Srivastava Deepak (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Srivastava Deepak (Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Srivastava Deepak (Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Graeme W. (Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Graeme W. (Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Doudna Jennifer (Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA) ,  Doudna Jennifer (Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA) ,  Doudna Jennifer (Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, 94720, USA) ,  Doudna Jennifer (Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA) ,  Doudna Jennifer (MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA) ,  Chang Edward (Department of Neurological Surgery, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Sohal Vikaas (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Sohal Vikaas (Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Lowenstein Daniel H. (Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Li Hao (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Li Hao (Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Agard David (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Agard David (Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Keiser Michael J. (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Keiser Michael J. (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Keiser Michael J. (Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Keiser Michael J. (Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shoichet Brian (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shoichet Brian (Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA) ,  von Zastrow Mark (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  von Zastrow Mark (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  von Zastrow Mark (Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Mucke Lennart (Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Mucke Lennart (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Finkbeiner Steven (Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Finkbeiner Steven (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Finkbeiner Steven (Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Gan Li (Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Gan Li (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Sestan Nenad (Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA) ,  Ward Michael E. (National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA) ,  Huttenhain Ruth (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Huttenhain Ruth (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Huttenhain Ruth (Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Nowakowski Tomasz J. (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Nowakowski Tomasz J. (Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Nowakowski Tomasz J. (The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Bellen Hugo J. (Departments of Molecular and Human Genetics and Neuroscience, Neurological Research Institute at TCH, Baylor College of Medicine, Houston, TX 77030, USA) ,  Bellen Hugo J. (Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA) ,  Frank Loren M. (Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Frank Loren M. (Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Frank Loren M. (Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Khokha Mustafa K. (Pediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA) ,  Lifton Richard P. (Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY 10065, USA) ,  Kampmann Martin (Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kampmann Martin (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kampmann Martin (Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kampmann Martin (Chan Zuckerberg Biohub, San Francisco, CA 94158, USA) ,  Ideker Trey (Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA) ,  State Matthew W. (Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA) ,  State Matthew W. (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krogan Nevan J. (Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krogan Nevan J. (Gladstone Institutes, San Francisco, CA 94158, USA) ,  Krogan Nevan J. (Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krogan Nevan J. (Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 174  号： 3  ページ： 505-520  発行年： 2018年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 自閉症スペクトラム障害,知的障害,てんかん,統合失調症およびTourre障害を含む神経精神疾患における遺伝子発見は加速されているが,蛋白質複合体および機能的経路レベルでの対応するデータセットなしで特異的仮説を生成することは困難であることが証明されている。ここでは,これらの条件の物理的および遺伝的相互作用ネットワークのマッピングを目的とした一つの経路を記述し,次にこれらのマップを用いてゲノムデータを神経生物学および最終的に臨床に結びつけた。これらの努力は,遺伝学者,構造生物学者,神経生物学者,システム生物学者,および臨床医のチームを含み,広範囲の実験アプローチを活用し,長期調査に必要な共同インフラストラクチャーを作成する。このイニシアティブは,癌,感染症および先天性心臓欠損に関与する遺伝子との有意な重複があるので,最終的に他の疾患に焦点を合わせた並列研究と交差する。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝学 ,  統合失調症 ,  ネットワーク ,  インフラストラクチャー ,  ゲノム ,  てんかん ,  先天性心疾患 ,  感染症 ,  遺伝子 ,  タンパク質複合体 ,  *知能障害 ,  神経生物学 ,  自然科学
準シソーラス用語： 臨床医 ,  自閉症スペクトラム障害 ,  *精神神経疾患 , 【Automatic Indexing@JST】

著者キーワード (11件)： 遺伝学 ,  プロテオミクス ,  システム生物学 ,  インタラクトーム ,  ネットワーク ,  経路 ,  収束 ,  精神細胞地図イニシアチブ ,  神経発達障害 ,  精神医学 ,  精神障害

分類 (3件)： 精神科の基礎医学  (GR01020I) ,  遺伝子発現  (EC02040Q) ,  中枢神経系  (EJ12030F)

タイトルに関連する用語 (6件)： 細胞 ,  地図 ,  神経精神疾患 ,  分子経路 ,  収束 ,  生物学