文献

J-GLOBAL ID：201802284285094403   整理番号：18A1424346

パーキンソン病と急速眼球運動睡眠行動障害におけるMAPTの完全配列決定とハプロタイプ分析【JST・京大機械翻訳】

Full sequencing and haplotype analysis of MAPT in Parkinson’s disease and rapid eye movement sleep behavior disorder

著者 (63件)： Li Jiao (Department of Neurology, Peking University Third Hospital, Beijing, China) ,  Li Jiao (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Ruskey Jennifer A. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Ruskey Jennifer A. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Arnulf Isabelle (Sleep Disorders Unit, Pitie Salpetriere Hospital, Centre de Recherche de l’Institut du Cerveau et de la Moelle Epiniere and Sorbonne Universities, UPMC Paris 6 univ, Paris, France) ,  Dauvilliers Yves (Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology Hopital-Gui-de Chauliac, CHU Montpellier, INSERM U1061, Montpellier, France) ,  Hu Michele T.M. (Oxford Parkinson’s Disease Centre (OPDC), University of Oxford, Oxford, United Kingdom) ,  Hu Michele T.M. (Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom) ,  Hogl Birgit (Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria) ,  Leblond Claire S. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Leblond Claire S. (Department of Human Genetics, McGill University, H3A 0G4, Montreal, QC, Canada) ,  Zhou Sirui (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Zhou Sirui (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Ambalavanan Amirthagowri (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Ambalavanan Amirthagowri (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Ross Jay P. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Ross Jay P. (Department of Human Genetics, McGill University, H3A 0G4, Montreal, QC, Canada) ,  Bourassa Cynthia V. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Bourassa Cynthia V. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Spiegelman Dan (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Spiegelman Dan (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Laurent Sandra B (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Laurent Sandra B (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Stefani Ambra (Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria) ,  Charley Monaca Christelle (University Lille north of France, Department of clinical neurophysiology and sleep center, CHU Lille, Lille, France) ,  Cochen De Cock Valerie (Sleep and neurology unit, Beau Soleil Clinic, Montpellier, France) ,  Cochen De Cock Valerie (EuroMov, University of Montpellier, Montpellier, France) ,  Boivin Michel (GRIP, Ecole de psychologie, Universite Laval, Quebec city, QC, Canada) ,  Boivin Michel (Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia) ,  Ferini-Strambi Luigi (Department of Neurological Sciences, Universita Vita-Salute San Raffaele, Milan, Italy) ,  Plazzi Giuseppe (Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy) ,  Plazzi Giuseppe (IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy) ,  Antelmi Elena (Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy) ,  Antelmi Elena (IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy) ,  Young Peter (Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Muenster, Germany) ,  Heidbreder Anna (Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Muenster, Germany) ,  Labbe Catherine (Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA) ,  Ferman Tanis J. (Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA) ,  Dion Patrick A. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Dion Patrick A. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Fan Dongsheng (Department of Neurology, Peking University Third Hospital, Beijing, China) ,  Desautels Alex (Centre d’Etudes Avancees en Medecine du Sommeil, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada) ,  Desautels Alex (Department of Neurosciences, Universite de Montreal, Montreal, QC, Canada) ,  Gagnon Jean-Francois (Centre d’Etudes Avancees en Medecine du Sommeil, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada) ,  Gagnon Jean-Francois (Departement de psychologie, Universite du Quebec a Montreal, Montreal, QC, Canada) ,  Dupre Nicolas (Division of Neurosciences, CHU de Quebec, Universite Laval, Quebec City, QC, Canada) ,  Dupre Nicolas (Department of Medicine, Faculty of Medicine, Universite Laval, Quebec City, QC, Canada) ,  Fon Edward A. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Fon Edward A. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Montplaisir Jacques Y. (Centre d’Etudes Avancees en Medecine du Sommeil, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada) ,  Montplaisir Jacques Y. (Department of Psychiatry, Universite de Montreal, Montreal, QC, Canada) ,  Boeve Bradley F. (Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA) ,  Postuma Ronald B. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Postuma Ronald B. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Postuma Ronald B. (Department of Neurology, Montreal General Hospital, Montreal, QC, Canada) ,  Rouleau Guy A. (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Rouleau Guy A. (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Rouleau Guy A. (Department of Human Genetics, McGill University, H3A 0G4, Montreal, QC, Canada) ,  Ross Owen A. (Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA) ,  Ross Owen A. (Department of Clinical Genomics, Mayo Clinic, Jacksonville, Florida, USA) ,  Gan-Or Ziv (Montreal Neurological Institute, McGill University, Montreal, QC, Canada) ,  Gan-Or Ziv (Department of Neurology and neurosurgery, McGill University, Montreal, QC, Canada) ,  Gan-Or Ziv (Department of Human Genetics, McGill University, H3A 0G4, Montreal, QC, Canada)
資料名： Movement Disorders  (Movement Disorders)
巻： 33  号： 6  ページ： 1016-1020  発行年： 2018年 
JST資料番号： W2689A  ISSN： 0885-3185  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景:MAPTハプロタイプはPDと関連するが,急速な眼球運動睡眠行動障害との関連は不明である。【目的】急速眼球運動睡眠行動障害におけるMAPT変異体の役割を研究する。【方法】:(a)PD(n=600),急速眼球運動睡眠行動障害(n=613)患者,および対照(n=981);(b)急速な眼球運動睡眠行動障害(n=271)と対照(n=950)を有するLewy小体患者による認知症。MAPT関連変異体とMAPTの全コード配列を分析した。年齢,性別,および民族調整分析を行い,MAPT,PD,および急速眼球運動睡眠行動障害の間の関連性を調べた。結果:MAPT-H2変異体は,PDと関連していた(オッズ比:0.62~0.65;P=0.010~0.019)が,急速な眼球運動睡眠行動障害とは関連していなかった。PDにおいて,H1ハプロタイプオッズ比は1.60(95%信頼区間:1.12-2.28;P=0.009)であり,H2オッズ比は0.68(95%信頼区間:0.48-0.96;P=0.03)であった。H2/H1ハプロタイプは,急速な眼球運動睡眠行動障害と関連しなかった。結論:著者らの結果は,PDにおけるMAPT-H2ハプロタイプの保護効果を確認し,その成分を定義する。さらに,著者らの結果は,MAPTが,この遺伝子座におけるPDにおけるよりも異なる遺伝的背景を強調して,急速な眼球運動睡眠行動障害において主要な役割を果たさないことを示唆する。Copyright 2018 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *Parkinson病 ,  Lewy小体 ,  患者 ,  *眼球運動 ,  *ハプロタイプ ,  信頼区間 ,  遺伝学 ,  *高速度 ,  民族 ,  認知症 ,  保護作用
準シソーラス用語： オッズ比 ,  性別 ,  *行為障害 ,  *レム睡眠行動障害 , 【Automatic Indexing@JST】

著者キーワード (4件)： REM睡眠行動障害 ,  パーキンソン病 ,  遺伝学 ,  MAPT

分類 (2件)： 遺伝的変異  (EC01030Y) ,  神経系の疾患  (GN03000O)

タイトルに関連する用語 (3件)： パーキンソン病 ,  急速眼球運動睡眠行動障害 ,  ハプロタイプ分析