文献

J-GLOBAL ID：201802284409264814   整理番号：18A1067959

1型糖尿病の上海漢民族患者における血清ビリルビン濃度と糖尿病性腎症との関係【JST・京大機械翻訳】

Relationship between serum bilirubin concentrations and diabetic nephropathy in Shanghai Han’s patients with type 1 diabetes mellitus

著者 (14件)： Li Xu (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Zhang Lei (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Chen Haibing (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Guo Kaifeng (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Yu Haoyong (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Zhou Jian (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Li Ming (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Li Qing (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Li Lianxi (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Yin Jun (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Liu Fang (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Bao Yuqian (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Han Junfeng (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...) ,  Jia Weiping (Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Chi...)
資料名： BMC Nephrology (Web)  (BMC Nephrology (Web))
巻： 18  号： 1  ページ： 114  発行年： 2017年 
JST資料番号： U7437A  ISSN： 1471-2369  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 【背景】最近の研究は,2型糖尿病患者における総ビリルビン濃度とアルブミン尿症の間の負の相関を強調する。著者らの研究は,1型糖尿病(T1DM)を有する中国人患者におけるビリルビン濃度と糖尿病性腎症(DN)の罹患率の間の関係を評価した。【方法】T1DMを有する合計258名の患者を募集して,ビリルビン濃度を糖尿病性腎症の有無にかかわらず患者の間で比較した。多重段階的回帰分析を用いて,ビリルビン濃度と24時間尿中ミクロアルブミンの間の関係を調べた。二成分ロジスティック回帰分析を行い,糖尿病性腎症の独立危険因子を評価した。参加者を総ビリルビン濃度(Q1,0.20-0.60;Q2,0.60-0.80;Q3,0.80-1.00;Q4,1.00-1.90mg/dL)の四分位に従って4つの群に分け,χ2乗検定を用いてT1DM患者におけるDNの罹患率を比較した。【結果】平均ビリルビン濃度は,DN群で0.56(四分位:0.43~0.68mg/dL)であり,非DN群(0.70[四分位:0.58~0.89mg/dL],P<0.001)より有意に低かった。スピアマンの相関分析により,ビリルビン濃度は24時間尿ミクロアルブミンと逆相関し(r=-0.13,P<0.05),多重段階的回帰分析はビリルビン濃度が24時間尿ミクロアルブミンと独立に関連することを示した。ロジスティック回帰分析では,ビリルビン濃度は腎症と有意に逆相関した。さらに,層別解析において,第1から第4の四分位群まで,増加したビリルビン濃度は,21.90%から2.00%までDNの罹患率の減少と関連していた。【結論】高ビリルビン濃度は,T1DM患者におけるアルブミン尿症およびDN罹患率と独立して負に関連している。Copyright 2018 The Author(s). All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 層別 ,  *ネフローゼ ,  *糖尿病性腎症 ,  *血清 ,  回帰分析 ,  罹患率 ,  2型糖尿病 ,  χ2乗検定 ,  危険因子 ,  *患者 ,  ラクタム ,  ポリエン ,  ビニル化合物 ,  ジカルボン酸
準シソーラス用語： ロジスティック回帰分析 ,  中国人 ,  アルブミン尿 ,  総ビリルビン , 【Automatic Indexing@JST】

著者キーワード (3件)： 1型糖尿病 ,  糖尿病性腎症 ,  ビリルビン濃度

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

物質索引 (1件)： ビリルビン

引用文献 (28件)：

• Nephrol Dial Transplant; The rising tide of diabetic nephropathy--the warning before the flood?; AE Raine; 10; 1995; 460-1; 10.1093/ndt/10.4.460; CR1;
• Diabetes; Role of oxidative stress in development of complications in diabetes; JW Baynes; 40; 1991; 405-12; 10.2337/diab.40.4.405; CR2;
• Science; Bilirubin is an antioxidant of possible physiological importance; R Stocker, Y Yamamoto, AF McDonagh, AN Glazer, BN Ames; 235; 1987; 1043-6; 10.1126/science.3029864; CR3;
• Mol Nutr Food Res; Heme, heme oxygenase and ferritin in vascular endothelial cell injury; J Balla, GM Vercellotti, V Jeney, A Yachie, Z Varga, JW Eaton, G Balla; 49; 2005; 1030-43; 10.1002/mnfr.200500076; CR4;
• Atherosclerosis; Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels; L Vítek, M Jirsa, M Brodanová, M Kalab, Z Marecek, V Danzig, L Novotný, P Kotal; 160; 2002; 449-56; 10.1016/S0021-9150(01)00601-3; CR5;

タイトルに関連する用語 (7件)： 1型糖尿病 ,  上海 ,  漢民族 ,  患者 ,  血清 ,  ビリルビン ,  糖尿病性腎症