文献

J-GLOBAL ID：201802289053000527   整理番号：18A1041340

前立腺3の6膜貫通上皮抗原は予後不良を予測し,膠芽腫増殖と浸潤を促進する【JST・京大機械翻訳】

Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion

著者 (22件)： Han Mingzhi (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Han Mingzhi (K G Jebsen Brain Tumor Research Center, Department of Biomedicine, University of Bergen, 5009, Bergen, Norway) ,  Xu Ran (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Xu Ran (Brain and Mind Center, Sydney Medical School and Faculty of Health Sciences, University of Sydney, Sydney, NSW, 2050, Australia) ,  Wang Shuai (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Yang Ning (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Ni Shilei (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Zhang Qing (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Xu Yangyang (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Zhang Xin (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Zhang Chao (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Wei Yuzhen (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Wei Yuzhen (Department of Neurosurgery, Jining No.1 People’s Hospital, Jiankang Road, Jining, 272011, China) ,  Ji Jianxiong (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Huang Bin (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Zhang Di (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Chen Anjing (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Li Wenjie (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Bjerkvig Rolf (K G Jebsen Brain Tumor Research Center, Department of Biomedicine, University of Bergen, 5009, Bergen, Norway) ,  Li Xingang (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Wang Jian (Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, 107# Wenhua Xi Road, Jinan, 250012, China) ,  Wang Jian (K G Jebsen Brain Tumor Research Center, Department of Biomedicine, University of Bergen, 5009, Bergen, Norway)
資料名： Neoplasia  (Neoplasia)
巻： 20  号： 6  ページ： 543-554  発行年： 2018年 
JST資料番号： W3158A  ISSN： 1476-5586  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 最近の証拠は,鉄調節因子の調節不全が癌病態生理において必須の役割を果たす可能性があることを示唆している。前立腺3(STEAP3)の6膜貫通上皮抗原は,細胞鉄取り込みとホメオスタシスに重要なメタロレダクターゼである。しかし,ヒト神経膠腫の発生におけるSTEAP3の臨床的意義と機能は不明のままである。公的に利用可能なデータベースの分析を通して,STEAP3が悪性神経膠腫,特に間充織神経膠腫分子サブタイプとイソクエン酸デヒドロゲナーゼ1/2(IDH1/2)野生型神経膠腫において高度に発現されることを見出した。神経膠腫におけるSTEAP3の発現レベルは患者の全生存(OS)と逆相関し,多変量Cox回帰分析により独立予後マーカーとして役立った。RNAノックダウンにより行った機能分析において,STEAP3の消失は,in vitroでの細胞増殖,浸潤,および球体形成,およびin vivoでの腫瘍増殖を含むグリオーマ細胞における攻撃的表現型を減弱した。最後に,STEAP3は,間充織転移を誘導し,トランスフェリン受容体(TfR)発現を促進し,STAT3-FoxM1軸シグナリングを活性化することにより,これらの活性を駆動する。まとめると,これらの結果は,STEAP3がグリオーマ進行における発癌性メディエーターとして機能し,従って疾患の治療のための潜在的治療標的であることを示す。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *前立腺 ,  細胞増殖 ,  間充織 ,  *浸潤 ,  ヒト ,  鉄 ,  患者 ,  in vitro実験 ,  *抗原 ,  病態生理 ,  RNA【核酸】 ,  神経膠腫 ,  *上皮 ,  ホメオスタシス
準シソーラス用語： *予後不良 , 【Automatic Indexing@JST】

分類 (2件)： 神経系の腫よう  (GN04000V) ,  腫ようの化学・生化学・病理学  (GE02030N)

タイトルに関連する用語 (9件)： 前立腺 ,  上皮 ,  抗原 ,  予後不良 ,  予測 ,  膠芽腫 ,  増殖 ,  浸潤 ,  促進