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J-GLOBAL ID：201802291502101699   整理番号：18A1153114

ヒト癌における環状RNA【JST・京大機械翻訳】

Circular RNAs in human cancer

著者 (37件)： Wang Yumin (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Wang Yumin (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Wang Yumin (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Mo Yongzhen (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Mo Yongzhen (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Mo Yongzhen (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Gong Zhaojian (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Gong Zhaojian (Department of Stomatolog, The Second Xiangya Hospital, Central South University, Changsha, China) ,  Yang Xiang (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Yang Mo (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Zhang Shanshan (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Xiong Fang (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Xiang Bo (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Xiang Bo (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Xiang Bo (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Zhou Ming (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Zhou Ming (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Zhou Ming (Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China) ,  Liao Qianjin (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Liao Qianjin (Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China) ,  Zhang Wenling (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Li Xiayu (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Li Xiayu (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Li Xiaoling (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Li Xiaoling (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Li Xiaoling (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Li Yong (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Li Yong (Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA) ,  Li Guiyuan (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Li Guiyuan (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Li Guiyuan (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Zeng Zhaoyang (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Zeng Zhaoyang (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Zeng Zhaoyang (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Xiong Wei (Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, China) ,  Xiong Wei (Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, China) ,  Xiong Wei (Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China)
資料名： Molecular Cancer (Web)  (Molecular Cancer (Web))
巻： 16  号： 1  ページ： 25  発行年： 2017年 
JST資料番号： U7336A  ISSN： 1476-4598  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： circRNAは新しいタイプのRNAである。次世代配列決定(NGS)の新しく開発された技術により,特にRNA-seq技術は30,000以上のcircRNAを既に見出している。それらの独特の構造のために,それらは線形RNAより安定である。circRNAは癌の発癌において重要な役割を果たす。circRNAの発現は患者の臨床的特徴と相関し,circRNAは細胞周期,アポトーシス,血管新生および浸潤を含む悪性表現型の多くの側面で重要な役割を果たしている。RNAスポンジとしての転移,RBPへの結合;または翻訳。したがって,circRNAと腫瘍の間の相互作用の機構をさらに研究することは意味がある。分子マーカーまたは潜在的標的としてのcircRNAの役割は,早期腫瘍診断,治療評価,予後予測,および腫瘍に対する遺伝子治療のような有望な応用展望を提供する。Copyright 2018 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  発癌 ,  血管新生 ,  アポトーシス ,  バイオマーカー ,  患者 ,  腫瘍 ,  *ヒト ,  細胞周期 ,  遺伝子療法 ,  *RNA【核酸】 ,  表現型
準シソーラス用語： 予後予測 ,  癌診断 ,  分子マーカー , 【Automatic Indexing@JST】

著者キーワード (5件)： 環状RNA ,  癌 ,  スプライシング ,  バイオマーカー ,  規制

分類 (2件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  遺伝子発現  (EC02040Q)

引用文献 (62件)：

• Cell; Isolation and characterization of Sendai virus DI-RNAs; D Kolakofsky; 8; 1976; 547-555; 10.1016/0092-8674(76)90223-3; CR1;
• Proc Natl Acad Sci U S A; Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures; HL Sanger, G Klotz, D Riesner, HJ Gross, AK Kleinschmidt; 73; 1976; 3852-3856; 10.1073/pnas.73.11.3852; CR2;
• Nature; Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells; MT Hsu, M Coca-Prados; 280; 1979; 339-340; 10.1038/280339a0; CR3;
• RNA; Exon circularization in mammalian nuclear extracts; Z Pasman, MD Been, MA Garcia-Blanco; 2; 1996; 603-610; CR4;
• FASEB J; Mis-splicing yields circular RNA molecules; C Cocquerelle, B Mascrez, D Hetuin, B Bailleul; 7; 1993; 155-160; CR5;

タイトルに関連する用語 (3件)： ヒト ,  癌 ,  環状RNA