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J-GLOBAL ID：201802297782138349   整理番号：18A0801943

ACE2/アンギオテンシン-(1-7)/MAS受容体軸:癌における多面的役割【JST・京大機械翻訳】

The ACE2/Angiotensin-(1-7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

著者 (14件)： Xu Juanjuan (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Fan Jinshuo (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Wu Feng (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Huang Qi (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Guo Mengfei (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Lv Zhilei (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Han Jieli (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Duan Limin (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Hu Guorong (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Chen Lian (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Liao Tingting (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Ma Wanli (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Tao Xiaonan (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ,  Jin Yang (Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)
資料名： Frontiers in Physiology (Web)  (Frontiers in Physiology (Web))
巻： 8  ページ： 276  発行年： 2017年 
JST資料番号： U7093A  ISSN： 1664-042X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 癌は死亡と障害の最も一般的な原因の1つであり,工業化された国における主要な経済的負担を代表する。レニン-アンギオテンシン系(RAS)は,脳,腎臓,心臓および血管における正常および病理生理学的過程の両方の最も重要な調節因子の1つとして良く認識されている。最近,RASの1つの成分であるアンギオテンシン変換酵素2/アンギオテンシン-(1-7)/ミトコンドリア集合受容体[ACE2/Ang-(1-7)/MASR]軸の活性化は,肺系,胃粘膜および癌の重要な成分として同定されている。しかしながら,癌を抑制または促進するACE2/Ang-(1-7)/MASR軸の能力は完全には解明されていない。本レビューでは,ACE2/Ang-(1-7)/MASR軸を標的とする癌治療のための可能な治療戦略への洞察を提供するために,ACE2,Ang-(1-7)およびMASRの基本的性質,役割および機構を研究する最近の実験および臨床研究に焦点を当てた。Copyright 2018 The Author(s). All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 病理 ,  ミトコンドリア ,  *受容体 ,  *アンギオテンシン ,  胃粘膜 ,  レニン・アンギオテンシン系 ,  血管 ,  治療計画 ,  レニン ,  心臓
準シソーラス用語： 臨床研究 ,  癌治療 ,  調節因子 ,  生理学的過程 ,  *アンギオテンシン変換酵素2 , 【Automatic Indexing@JST】

著者キーワード (6件)： レニン-アンギオテンシン系(RAS) ,  アンギオテンシン変換酵素2(ACE2) ,  アンギオテンシン-(1-7) ,  MAS受容体 ,  癌 ,  薬剤耐性

分類 (1件)： 循環系の基礎医学  (GJ01020K)

タイトルに関連する用語 (5件)： ACE2 ,  アンギオテンシン ,  Mas受容体 ,  癌 ,  役割