2022 - 2022 Controlled epigenetic disturbances induce the senescence in cancer cells
2019 - 2022 Comprendre et cibler un oncogène épigénétique humain, UHRF1.
2017 - 2019 精子クロマチンにおけるヒストン残存領域の規則性解明
論文 (14件):
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, et al. Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature Communications. 2024
Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, et al. A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation. Nucleic acids research. 2023
Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Anaelle Azogui, Laure Ferry, Olivier Kirsh, Fumihito Miura, Sarah Battault, Kosuke Yamaguchi, Marthe Laisné, et al. A genome-wide screen reveals new regulators of the 2-cell-like cell state. Nature Structural & Molecular Biology. 2023
Mélina Blanco, Laila El Khattabi, Clara Gobé, Marion Crespo, Manon Coulée, Alberto de la Iglesia, Côme Ialy-Radio, Clementine Lapoujade, Maëlle Givelet, Marion Delessard, et al. DOT1L regulates chromatin reorganization and gene expression during sperm differentiation. EMBO reports. 2023. e56316
Yuko Fukuda, Keishi Shintomi, Kosuke Yamaguchi, Yasuhiro Fujiwara, Yuki Okada. Solubilization of Mouse Sperm Chromatin for Sequencing Analyses Using a Chaperon Protein. Methods in molecular biology (Clifton, N.J.). 2023. 2577. 161-173
Transient and prolonged epigenetic disturbances: effect on cell identity and transformation
(Labex WHO AM I? Exploring identity: from molecules to individuals 2022)
Time resolved multi-omic analyses reveal new UHRF1 functions.
(6th Max Planck Epigenetics Meeting 2022)
Controlled epigenetic disturbances induce the senescence in cancer cells
(第15回日本エピジェネティクス研究会年会 2022)
AID system revealed UHRF1/ DNMT1 specific functions in colorectal cancer cells for cell cycle and epigenetics state maintenance.
(25èmes Journées Jeunes Chercheurs de la Fondation ARC 2021 2021)