リムキーシアン

Lim Kee Siang

所属機関・部署：
職名： Specially Appointed Assistant Professor

研究分野 (6件)：分子生物学 , ウイルス学 , 生体化学 , ナノバイオサイエンス , 腫瘍生物学 , 細胞生物学

研究キーワード (6件)： Viral proteins , Nanoimaging , Cancer Biology , Oncoimmunology , High Speed Atomic Force Microscopy , Nuclear Pore Complex

競争的資金等の研究課題 (2件)：

2020 - 2024 Real-time observation of native conformations and molecular behaviors of viral fusion proteins using high-speed atomic force microscopy (HS-AFM).
2019 - 2020 Direct visualization of avian influenza H5N1 Hemagglutinin precursor and its conformational change by high-speed atomic force microscopy

論文 (27件)：

Yujia Qiu, Elma Sakinatus Sajidah, Sota Kondo, Shinnosuke Narimatsu, Muhammad Isman Sandira, Yoshiki Higashiguchi, Goro Nishide, Azuma Taoka, Masaharu Hazawa, Yuka Inaba, et al. An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy. Cells. 2024. 13. 3. 279-279
Masaharu Hazawa, Dini Kurnia Ikliptikawati, Yuki Iwashima, De-Chen Lin, Yuan Jiang, Yujia Qiu, Kei Makiyama, Koki Matsumoto, Akiko Kobayashi, Goro Nishide, et al. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chemical Biology. 2023
Zuzana Dunajova, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte Brandis, Philipp Velicky, Johann Georg Danzl, Richard W. Wong, Jens Elgeti, Edouard Hannezo, et al. Chiral and nematic phases of flexible active filaments. Nature Physics. 2023
Goro Nishide, Keesiang Lim, Maiki Tamura, Akiko Kobayashi, Qingci Zhao, Masaharu Hazawa, Toshio Ando, Noritaka Nishida, Richard W. Wong. Nanoscopic Elucidation of Spontaneous Self-Assembly of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open Reading Frame 6 (ORF6) Protein. The Journal of Physical Chemistry Letters. 2023. 8385-8396
Dini Kurnia Ikliptikawati, Nozomi Hirai, Kei Makiyama, Hemragul Sabit, Masashi Kinoshita, Koki Matsumoto, Keesiang Lim, Makiko Meguro-Horike, Shin-ichi Horike, Masaharu Hazawa, et al. Nuclear transport surveillance of p53 by nuclear pores in glioblastoma. Cell Reports. 2023. 112882-112882

MISC (2件)：

LIM Keesiang, 西出梧朗, 中山隆宏, 華山力成, 華山力成, 安藤敏夫, WONG Richard W., WONG Richard W. SARS-CoV-2スパイクタンパク質の構造ダイナミクスとACE2受容体および小さな細胞外小胞との相互作用のミリ秒追跡。. 日本生化学会大会(Web). 2022. 95th
Kee Siang Lim, Ley Fang Kua, Kosaku Mimura, Kensuke Shiraishi, Wee Joo Chng, Wei Peng Yong, Dario Campana, Koji Kono. Implication of highly cytotoxic natural killer cells for esophageal cancer treatment. CANCER RESEARCH. 2015. 75

講演・口頭発表等 (15件)：

Nanoscopic Evaluation of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM
(The 7th WPI NanoLSI Symposium 2023)
Nanoscopic Evaluation of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM.
(The 70th Annual Meeting of the Japanese Society for Virology 2023)
Nanoscopic Evaluation of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM
(The 3rd Meeting of Cross-Scale Biology Conference 2023)
Nanoscopic Evaluation of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM.
(The 23rd annual meeting of the Protein Science Society of Japan 2023)
Structural dynamics of SARS-CoV-2 spike (S) protein and its interaction with ACE2 receptor and small extracellular vesicles
(Cross-Scale Biology 1st Wakate meeting 2022)

学歴 (2件)：

2012 - 2017 National University of Singapore (NUS) Cancer Science Institute Cancer Biology
2005 - 2009 National University of Malaysia (UKM) Biomedical Science with Honours

経歴 (2件)：

2017/05 - 2018/05 National University of Singapore Cancer Science Institute (CSI) Postdoctoral Researcher
2010/01 - 2012/06 National University of Singapore Department of Surgery Research Assistant

受賞 (2件)：

2021/07 - 金沢大学 Papers of the Month 高速AFMによるヒストンとDNAとの相互作用の可視化
2020/11 - 金沢大学 Papers of the Month 高速AFMを利用した感染宿主細胞内での膜融合におけるインフルエンザウイルスHAの働き方の解明

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