研究者
J-GLOBAL ID:201901019063129060   更新日: 2022年07月14日

関 晃裕

セキ アキヒロ | Seki Akihiro
所属機関・部署:
職名: 特任助教
研究分野 (1件): 消化器内科学
競争的資金等の研究課題 (5件):
  • 2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells
  • 2020 - 2022 非アルコール性脂肪肝炎による腸管免疫・癌微小環境動態と大腸癌への影響の解明
  • 2019 - 2021 iPS細胞由来間葉系幹細胞の免疫修飾作用を用いた炎症性腸疾患の治療効果と機序解明
  • 2014 - 2017 脂肪組織由来間質細胞群の細胞分画特性解析と肝修復再生療法の開発
  • 間葉系幹細胞による非アルコール性脂肪性肝炎に対する治療効果機序解明 (採択番号16K19334,同年から海外留学を行うため,採択を辞退した)
論文 (40件):
  • Masaaki Yano, Alessandro Nasti, Akihiro Seki, Kosuke Ishida, Masatoshi Yamato, Hiiro Inui, Norihiko Ogawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, et al. Characterization of adipose tissue-derived stromal cells of mice with nonalcoholic fatty liver disease and their use for liver repair. Regenerative therapy. 2021. 18. 497-507
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Kazunori Kawaguchi, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, et al. Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Regenerative therapy. 2021. 18. 97-101
  • Kazunori Kawaguchi, Yoshio Sakai, Takeshi Terashima, Tetsuhiro Shimode, Akihiro Seki, Noriaki Orita, Yumie Takeshita, Tetsuro Shimakami, Hajime Takatori, Kuniaki Arai, et al. Decline in serum albumin concentration is a predictor of serious events in nonalcoholic fatty liver disease. Medicine. 2021. 100. 31. e26835
  • Han Chen, Kouki Nio, Taro Yamashita, Hikari Okada, Ru Li, Tsuyoshi Suda, Yingyi Li, Phuong Thi Bich Doan, Akihiro Seki, Hidetoshi Nakagawa, et al. BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma. Molecular oncology. 2021. 15. 8. 2203-2218
  • Kosuke Ishida, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Masatoshi Yamato, Hiiro Inui, Takuya Komura, Taro Yamashita, Kuniaki Arai, Tatsuya Yamashita, et al. Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice. Stem cell research. 2021. 54. 102425-102425
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MISC (24件):
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Kazunori Kawaguchi, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, et al. INVESTIGATOR-INITIATED CLINICAL TRIAL OF AUTOLOGOUS ADIPOSE TISSUE-DERIVED REGENERATIVE (STEM) CELLS THERAPY FOR STEATOHEPATITIS-RELATED CIRRHOSIS. HEPATOLOGY. 2020. 72. 1020-1021
  • 藤永 晴夫, 酒井 佳夫, 山下 竜也, 荒井 邦明, 寺島 健志, 小村 卓也, 関 晃裕, 川口 和紀, ナスティ・アレッサンドロ, 吉田 佳子, et al. 膵臓癌細胞株に対する陽子線・X線照射における遺伝子発現プロファイル変化の特徴. 膵臓. 2018. 33. 3. 468-468
  • Alessandro Nasti, Yoshio Sakai, Akihiro Seki, Geraldine Belen Buffa, Takuya Komura, Hatsune Mochida, Masatoshi Yamato, Keiko Yoshida, Tuyen T. B. Ho, Masayuki Takamura, et al. Eur. J. Immunol. 12'17. European Journal of Immunology. 2017. 47. 12. Cover Picture-NA
  • Masatoshi Yamato, Yoshio Sakai, Hatsune Mochida, Akihiro Seki, Keiko Yoshida, Tuyen T. Ho, Alessandro Nasti, Takashi Wada, Shuichi Kaneko. Adipose tissue derived stromal/stem cells retarded progression of hepatic fibrosis by suppressing IL17A related inflammation in early stage of NASH. HEPATOLOGY. 2017. 66. 1041A-1041A
  • Yoshio Sakai, Akihiro Seki, Hajime Sunagozaka, Takeshi Terashima, Hatsune Mochida, Alessandro Nasti, Masatoshi Yamato, Kousuke Ishida, Masao Honda, Shuichi Kaneko. Clinical study of liver regenerative therapy of cirrhosis using autologous adipose tissue-derived stromal cells and the biological characters of the obtained cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 394-394
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講演・口頭発表等 (5件):
  • The Gut Microbiota of Pregnant Women with Crohn's Disease and their Babies is Associated with Abnormalities in the Adaptive Immune System - Results from the Meconium Study.
    (米国消化器病学会週間 2018)
  • CD45+ fraction in murine adipose tissue-derived stromal cells is therapeutical to Concanavalin A-induced murine acute hepatitis model.
    (米国肝臓学会議 2015)
  • Immunomodulation effect of adipose-tissue derived stromal/stem cell is capable of suppressing murine Concanavalin A-induced hepatitis.
    (米国肝臓学会議 2013)
  • Therapeutic effect of adipose derived mesenchymal stem cell to murine NASH liver cirrhosis inactivating Kupffer/Macrophage and helper T cell
    (米国肝臓学会議 2012)
  • Adipose tissue derived mesenchymal stem cells are capable to modulate liver inflammation in mouse models of non-alcoholic steatohepatitis.
    (米国肝臓学会議 2009)
学歴 (2件):
  • 2007 - 2014 金沢大学 恒常性制御学講座博士課程
  • 1998 - 2005 富山医科薬科大学 医学科
経歴 (3件):
  • 2019/11 - 現在 金沢大学 医薬保健研究域医学系 特任助教
  • 2016/04 - 2019/03 Icahn School of Medicine at Mount Sinai gastroenterology post doctoral fellow
  • 2014/04 - 2016/03 金沢大学 医学部附属病院 特任助教
受賞 (2件):
  • 2016/02 - 国際ロータリークラブ 第2610地区グローバル補助金
  • 2013/10 - 日本肝臓学会 12th Otsuka award 肝硬変マウスモデルにおける脂肪組織由来間葉系幹細胞による肝修復再生療法の検討
所属学会 (5件):
日本免疫学会 ,  日本肝臓学会 ,  日本消化器内視鏡学会 ,  日本消化器病学会 ,  日本内科学会
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