文献

J-GLOBAL ID：201902223542982921   整理番号：19A2711657

バイオバンク化ヒト骨髄間質細胞の多パラメータ解析は,表現型および機能特性に対するドナー年齢および軽度共存症に対してほとんど影響を示さない【JST・京大機械翻訳】

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

著者 (51件)： Andrzejewska Anastazja (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Andrzejewska Anastazja (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Andrzejewska Anastazja (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Catar Rusan (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Catar Rusan (Department of Nephrology and Internal Intensive Care Medicine, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Schoon Janosch (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Schoon Janosch (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Schoon Janosch (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Qazi Taimoor Hasan (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Qazi Taimoor Hasan (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Qazi Taimoor Hasan (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Sass Frauke Andrea (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Sass Frauke Andrea (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Sass Frauke Andrea (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Jacobi Dorit (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Jacobi Dorit (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Blankenstein Antje (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Blankenstein Antje (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Reinke Simon (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Reinke Simon (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Krueger David (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Streitz Mathias (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Streitz Mathias (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Schlickeiser Stephan (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Schlickeiser Stephan (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Richter Sarina (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Richter Sarina (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Souidi Naima (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Souidi Naima (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Souidi Naima (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Beez Christien (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Beez Christien (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Beez Christien (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Kamhieh-Milz Julian (Department of Transfusion Medicine, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Krueger Ulrike (BIH Core Unit Genomics Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health, Berlin, Germany) ,  Zemojtel Tomasz (BIH Core Unit Genomics Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health, Berlin, Germany) ,  Juerchott Karsten (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Strunk Dirk (Berlin Center for Advanced Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Reinke Petra (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Reinke Petra (Institute of Medical Immunology, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Reinke Petra (Spinal Cord Injury and Tissue Regeneration Center, Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria) ,  Duda Georg (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Duda Georg (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Duda Georg (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Moll Guido (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Moll Guido (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Moll Guido (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Moll Guido (Department of Nephrology and Internal Intensive Care Medicine, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Geissler Sven (BIH Center for Regenerative Therapies (BCRT), Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany) ,  Geissler Sven (Berlin-Brandenburg School for Regenerative Therapies, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany) ,  Geissler Sven (Julius Wolff Institute, Charite Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, BIH, Berlin, Germany)
資料名： Frontiers in Immunology (Web)  (Frontiers in Immunology (Web))
巻： 10  ページ： 2474  発行年： 2019年 
JST資料番号： U7074A  ISSN： 1664-3224  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： ヒト骨髄由来間質細胞(BMSC)の不均一集団は,変性および免疫障害を治療するための最も頻繁に試験された細胞治療の中にあり,それは主に老化集団において発生する。現在,高度なドナー年齢と一般的に関連する共存症がex vivo拡張BMSCsの特性に影響するかどうかは不明である。そこで,著者らのバイオバンク(n=10およびn=13,平均年齢38および72歳)からの成人および高齢者ドナーから細胞を層別化し,それらの表現型および機能的性能を,多能性間葉間質細胞(MSCs)を定義するための最小基準として典型的に使用される多重アッセイを用いて比較した。両コホートからのBMSCはMSCに対する標準基準を満たし,類似の形態,成長速度論,遺伝子発現プロファイル,プロ血管新生及び免疫抑制能及び脂肪生成,軟骨形成及び骨形成系統に分化する能力を示すことを見出した。著者らは,成体と高齢のコホートからの細胞の間に実質的な違いは見られなかった。陽性対照として,in vitro老化および炎症性サイトカイン刺激の影響を検討した。両条件はドナー年齢に無関係に細胞特性に明らかに影響した。in vivoドナー老化よりもin vitro老化がBMSC特性に影響すると結論した。Copyright 2019 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *表現型 ,  老人 ,  老化 ,  汎用性 ,  成体 ,  in vitro実験 ,  *ドナー ,  骨形成 ,  *ヒト ,  *間質細胞 ,  母集団 ,  *骨髄 ,  間充織
準シソーラス用語： *共存罹患 ,  *バイオバンク , 【Automatic Indexing@JST】

著者キーワード (6件)： 細胞療法 ,  骨髄間質細胞 ,  間葉系間質細胞 ,  in vivoおよびin vitro老化 ,  共存症 ,  in vitro効力アッセイ

分類 (2件)： 免疫反応一般  (ED03010T) ,  細胞生理一般  (EF02010S)

引用文献 (99件)：

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タイトルに関連する用語 (10件)： バイオバンク ,  ヒト ,  骨髄間質細胞 ,  パラメータ解析 ,  表現型 ,  機能特性 ,  ドナー ,  年齢 ,  軽度 ,  共存症