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J-GLOBAL ID：201902224896755453   整理番号：19A1898630

IRE1α-XBP1S軸による栄養素アベイラビリティへのCOPII小胞輸送の共役【JST・京大機械翻訳】

Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis

著者 (22件)： Liu Lin (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Cai Jie (Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China) ,  Wang Huimin (The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing 100101, China) ,  Liang Xijun (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Zhou Qian (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Ding Chenyun (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Zhu Yuangang (The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing 100101, China) ,  Fu Tingting (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Guo Qiqi (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Xu Zhisheng (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Xiao Liwei (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Liu Jing (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Yin Yujing (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...) ,  Fang Lei (The State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine, Nanjing University, Nanjing 210093, China) ,  Xue Bin (The State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine, Nanjing University, Nanjing 210093, China) ,  Wang Yan (Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China) ,  Meng Zhuo-Xian (Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China) ,  He Aibin (Peking Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China) ,  Li Jian-Liang (Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709) ,  Liu Yong (Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China) ,  Chen Xiao-Wei (The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing 100101, China) ,  Gan Zhenji (The State Key Laboratory of Pharmaceutical Biotechnology-MOE Key Laboratory of Model Animals for Disease Study, Department of Spine Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanji...)
資料名： Proceedings of the National Academy of Sciences of the United States of America  (Proceedings of the National Academy of Sciences of the United States of America)
巻： 116  号： 24  ページ： 11776-11785  発行年： 2019年 
JST資料番号： D0387A  ISSN： 0027-8424  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 細胞質コート蛋白質複合体II(COPII)は,蛋白質と脂質カーゴの効率的な輸送に必須な進化的に保存された機械である。COPII機械が栄養状態の変化に応じて代謝要求を満たすためにどのように調節されているかは,ほとんど研究されていない。ここでは,COPII小胞輸送の動的変化が,栄養利用性の生理学的変動により生細胞とマウス肝臓の両方で細胞小胞体(ER)ストレスを扱う重要な転写因子である転写因子Xボックス結合蛋白質1(XBP1s)の活性化を平行することを示す。ライブセルイメージング法を用いて,XBP1sがCOPI依存性輸送を促進するのに十分であり,栄養促進効果を仲介することを示した。高スループットDNA配列決定(ChIP-seq)とRNA配列解析と結合したクロマチン免疫沈降(ChIP)は,栄養シグナルがCOPII輸送関連遺伝子のプロモーターの動的XBP1s占有を誘導し,それによりCOPI仲介輸送過程を駆動することを明らかにした。イノシトール要求酵素1α(IRE1α)-XBP1Sシグナル伝達分枝の肝臓特異的破壊はCOPII小胞輸送の減少をもたらす。肝臓IRE1αを欠くマウスにおけるXBP1sの再活性化は,COPI仲介リポ蛋白質分泌を回復し,脂肪肝および脂質血症表現型を逆転させる。したがって,著者らの結果は,肝臓蛋白質と脂質輸送の代謝制御における以前に評価されていない機構を示している:IRE1α-XBP1s軸は栄養状態とCOPII小胞輸送を統合する栄養素感知調節性のものとして機能する。Copyright 2019 The Author(s). Published by PNAS. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 細胞情報伝達 ,  酵素 ,  脂質 ,  *栄養素 ,  代謝 ,  転写因子 ,  小胞体 ,  分泌 ,  マウス ,  プロモーター領域 ,  *小胞輸送 ,  表現型
準シソーラス用語： ライブイメージング ,  生細胞 ,  *IRE1α蛋白質 , 【Automatic Indexing@JST】

著者キーワード (5件)： COPII ,  代謝センシング ,  XBP1S ,  栄養素アベイラビリティ ,  肝脂肪症

分類 (3件)： 細胞生理一般  (EF02010S) ,  遺伝子発現  (EC02040Q) ,  生物学的機能  (EB03040U)

タイトルに関連する用語 (6件)： IRE1α ,  栄養素 ,  アベイラビリティ ,  COPII ,  小胞輸送 ,  共役