文献

J-GLOBAL ID：201902227608937011   整理番号：19A1538498

原発性胆汁性胆管炎における特異的抗核自己抗体サブ表現型のゲノムワイド関連研究【JST・京大機械翻訳】

Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis

著者 (51件)： Wang Chan (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Zheng Xiaodong (Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, and Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China & Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, China) ,  Jiang Peng (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Tang Ruqi (Department of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China) ,  Gong Yuhua (Department of Laboratory Medicine, The Third People’s Hospital of Zhenjiang, Zhenjiang, Jiangsu, China) ,  Dai Yaping (Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Wuxi, Jiangsu, China) ,  Wang Lan (Department of Laboratory Medicine, The 81st Hospital of PLA, Nanjing, Jiangsu, China) ,  Xu Ping (Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China) ,  Sun Wenjuan (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Wang Lu (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Han Chongxu (Department of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China) ,  Jiang Yuzhang (Department of Laboratory Medicine, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu, China) ,  Wei Yiran (Department of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China) ,  Zhang Kui (Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China) ,  Wu Jian (Department of Rheumatology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China) ,  Shao Youlin (Department of Hepatology, The Third People’s Hospital of Changzhou, Changzhou, Jiangsu, China) ,  Gao Yueqiu (Department of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Yu Jianjiang (Department of Laboratory Medicine, Jiangyin People’s Hospital, Southeast University, Jiangyin, Jiangsu, China) ,  Hu Zhigang (Department of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China) ,  Zang Zhidong (Department of Hepatology, The Second Hospital of Nanjing, Southeast University, Nanjing, Jiangsu, China) ,  Zhao Yi (Department of Gastrointestinal Endoscopy, Eastern Hepatobiliary Surgery Hospital, Shanghai, China) ,  Wu Xudong (Department of Gastroenterology, Yancheng First People’s Hospital, Yancheng, Jiangsu, China) ,  Dai Na (Department of Gastroenterology, Jiangsu University Affiliated Kunshan Hospital, Kunshan, Jiangsu, China) ,  Liu Lei (Department of Gastroenterology, Yixing People’s Hospital, Yixin, Jiangsu, China) ,  Nie Jinshan (Department of Gastroenterology, Taicang First People’s Hospital, Soochow University, Taicang, Jiangsu, China) ,  Jiang Bo (Department of Hepatology, Jingjiang Second People’s Hospital, Jingjiang, Jiangsu, China) ,  Lin Maosong (Department of Gastroenterology, Taizhou People’s Hospital, Taizhou, Jiangsu, China) ,  Li Li (Department of Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China) ,  Li You (Department of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China) ,  Chen Sufang (Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China) ,  Shu Lixin (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Qiu Fang (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Wu Qiuyuan (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Zhang Mingming (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Chen Ru (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Jawed Rohil (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Zhang Yu (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Shi Xingjuan (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Zhu Zhen (Department of Hepatology, The Third People’s Hospital of Changzhou, Changzhou, Jiangsu, China) ,  Pei Hao (Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Wuxi, Jiangsu, China) ,  Huang Lihua (Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Wuxi, Jiangsu, China) ,  Zhao Weifeng (Department of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China) ,  Tian Ye (Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China) ,  Zhu Xiang (Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China) ,  Qiu Hong (Department of Laboratory Medicine, The 81st Hospital of PLA, Nanjing, Jiangsu, China) ,  Gershwin M. Eric (Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA) ,  Chen Weichang (Department of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China) ,  Seldin Michael F. (Department of Biochemistry and Molecular Medicine, University of California at Davis School of Medicine, Davis, CA) ,  Liu Xiangdong (Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China) ,  Sun Liangdan (Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, and Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China & Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, China) ,  Ma Xiong (Department of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China)
資料名： Hepatology  (Hepatology)
巻： 70  号： 1  ページ： 294-307  発行年： 2019年 
JST資料番号： T0889A  ISSN： 0270-9139  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： スペックル100kDa(sp100)と糖蛋白質210(gp210)に対する抗核抗体は,不確実/論争の臨床的または予後的有意性の原発性胆汁性胆管炎(PBC)の特異的血清学的マーカーである。sp100とgp210自己抗体サブ表現型に関連する遺伝的決定因子を研究するために,著者らはそれらの自己抗体状態に基づく930のPBC症例の全ゲノム関連分析を行い,続いて1,252のPBC症例における複製研究を行った。単一ヌクレオチド多型rs492899(P=3.27×10~22;オッズ比[OR],2.90;95%信頼区間[CI],2.34~3.66)とrs1794280(P=5.78×10~28;OR,3.89;95%CI,3.05~4.96)を,sp100自己抗体と関連したヒト主要組織適合複合体(MHC)領域で確認した。しかし,遺伝子変異体はgp210自己抗体と関連すると同定されなかった。sp100自己抗体に関連する特異的古典的ヒト白血球抗原(HLA)対立遺伝子またはアミノ酸をさらに定義するために,中国人MHC参照データベースを用いて922のPBC症例(211の抗sp100陽性対711の陰性症例)を実施した。条件分析により,HLA-DRβ1Asn77/Arg74,DRβ1Ser37及びDPβ1Lys65がsp100産生の主要決定因子であることを同定した。古典的HLA対立遺伝子については,最も強い関連性はDRB1*03:01(P=1.51×10~-9;OR,2.97;95%CI,2.06~4.29)であった。古典的HLA対立遺伝子を用いた回帰分析により,DRB1*03:01,DRB1*15:01,DRB1*01,およびDPB1*03:01対立遺伝子がsp100自己抗体とHLA会合の大部分を説明できることを示した。結論:本研究は,PBC患者において,sp100自己抗体に対する有意な遺伝的素因を示したが,gp210自己抗体,サブ表現型は示さなかった。これらの知見がPBC病因および/または治療に対して臨床的意義を有するかどうかを決定するために,さらなる研究が必要である。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： HLA-DR ,  *表現型 ,  ヒト ,  信頼区間 ,  抗核抗体 ,  病因 ,  アミノ酸 ,  一塩基多型 ,  *自己抗体 ,  予後 ,  回帰分析 ,  対立遺伝子 ,  遺伝
準シソーラス用語： 遺伝素因 ,  MHC【遺伝子】 , 【Automatic Indexing@JST】

分類 (3件)： 消化器の疾患  (GH03000W) ,  消化器の基礎医学  (GH01020E) ,  免疫性疾患・アレルギー性疾患一般  (GD04010C)

タイトルに関連する用語 (7件)： 原発性胆汁性胆管炎 ,  核 ,  自己抗体 ,  サブ ,  表現型 ,  ゲノム ,  研究