文献

J-GLOBAL ID：201902229736669540   整理番号：19A0487468

ドミナントネガティブp53変異体R248Qは口腔扁平上皮癌細胞の運動性活性および浸潤活性を増加させる

Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells

著者 (10件)： NAKAZAWA Seitaro (Department of Gerodontology, Division of Oral Health Science, Graduate School of Dental Medicine) ,  SAKATA Ken-ichiro (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  LIANG Shanshan (The Key Laboratory of Biomarker High Throughput-Screening and Target Translation of Breast and Gastrointestinal Tumor, Oncology department of Affiliated Zhongshan Hospital of Dalian University) ,  YOSHIKAWA Kazuhito (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  IIZASA Hisashi (Department of Microbiology, Shimane University Faculty of Medicine) ,  TADA Mitsuhiro (Department of Neurosurgery, Rumoi Municipal Hospital) ,  HAMADA Jun-ichi (Health Sciences University of Hokkaido, School of Nursing and Social Services) ,  KASHIWAZAKI Haruhiko (Section of Geriatric Dentistry and Perioperative Medicine in Dentistry, Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science) ,  KITAGAWA Yoshimasa (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  YAMAZAKI Yutaka (Department of Gerodontology, Division of Oral Health Science, Graduate School of Dental Medicine)
資料名： Biomedical Research (Web)  (Biomedical Research (Web))
巻： 40  号： 1  ページ： 37-49(J-STAGE)  発行年： 2019年 
JST資料番号： U1102A  ISSN： 1880-313X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 腫瘍抑制遺伝子TP53(遺伝子)は,細胞周期停止,DNA修復...

シソーラス用語： ヒト ,...
準シソーラス用語： *腫瘍再発

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分類 (3件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  歯と口腔の腫よう  (GT04000N) ,  分子遺伝学一般  (EC02010J)

引用文献 (13件)：

• 1 Albrecht-Buehler G (1977) The phagokinetic tracks of 3T3 cells. Cell 11, 395-404.
• 2 Frazier MW, He X, Wang J, Gu Z, Cleaveland JL and Zambetti GP (1998) Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain. Mol Cell Biol 18, 3735-3743.
• 3 Hassan, N, Tada M, Hamada J, Kashiwazaki H, Kameyama T, Akhter R, Yamazaki Y, Yano M, Inoue N and Moriuchi T (2008) Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer. Cancer Letter 270, 108-19.
• 4 Kashiwazaki, H., Tonoki H, Tada M, Chiba I, Shindoh M, Totsuka Y, Iggo R and Moriuchi T (1997) High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay. Oncogene 15, 2667-2674.
• 5 Lane DP (1992) Cancer. p53, guardian of genome. Nature 358, 15-16.

タイトルに関連する用語 (7件)： ドミナントネガティブ ,  p53 ,  変異体 ,  口腔扁平上皮癌細胞 ,  運動性 ,  活性 ,  浸潤