文献

J-GLOBAL ID：201902245946325899   整理番号：19A1790108

Major組織適合性複合体不適合マウス肝移植における移植片対腫瘍効果【JST・京大機械翻訳】

Graft-Versus-Tumor Effect in Major Histocompatibility Complex-Mismatched Mouse Liver Transplantation

著者 (53件)： Yu Dongdong (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Yu Dongdong (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Yu Dongdong (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Yu Dongdong (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Yu Dongdong (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Wang Lidong (Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China) ,  Wu Tianchun (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Wu Tianchun (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Wu Tianchun (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Wu Tianchun (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Wu Tianchun (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Zhang Yaohui (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zhang Yaohui (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Zhang Yaohui (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Zhang Yaohui (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Zhang Yaohui (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Tian Yang (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Tian Yang (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Tian Yang (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Tian Yang (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Tian Yang (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China) ,  Wang Yan (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Wang Yan (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Wang Yan (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Wang Yan (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Wang Yan (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Cui Chenwei (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Cui Chenwei (Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China) ,  Li Hui (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Li Hui (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Li Hui (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Li Hui (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Li Hui (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Zhang Jinhua (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zhang Jinhua (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Zhang Jinhua (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Zhang Jinhua (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Zhang Jinhua (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Zhou Lin (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zhou Lin (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Zhou Lin (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Zhou Lin (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Zhou Lin (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Yan Sheng (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Yan Sheng (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Yan Sheng (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Yan Sheng (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China) ,  Yan Sheng (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China) ,  Zheng Shusen (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zheng Shusen (National Health and Family Planning Commission of China Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China) ,  Zheng Shusen (Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou, China) ,  Zheng Shusen (Key Laboratory of Organ Transplantation, Hangzhou, China) ,  Zheng Shusen (Collaborative Innovation Center for Diagnosis Treatment of Infectious Disease, Hangzhou, China)
資料名： Liver Transplantation  (Liver Transplantation)
巻： 25  号： 8  ページ： 1251-1264  発行年： 2019年 
JST資料番号： A1616A  ISSN： 1527-6465  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 肝移植(LT)は現在,肝細胞癌(HCC)の治療および他の肝臓悪性腫瘍の代替治療において重要な方法と考えられている。ここでは,移植片対腫瘍(GVT)効果が同種肝移植(allo LT)に存在することを示した。手術後の腫瘍におけるレシピエントT細胞の広範な浸潤と有意な活性化により示されるように,細胞由来T細胞はallo LTのGVT過程において重要な役割を果たした。さらに,この過程は腫瘍における免疫微小環境を改善することによりドナー由来T/B細胞に関連しており,インターフェロン-γ(IFN-γ),腫瘍壊死因子α(TNF-α),インターロイキン-2(IL-2),IL-6,IL-16,ケモカイン(C-X-Cモチーフ)リガンド10(CXCL10)およびIL-10とIL-4のレベルが腫瘍部位で低下した。加えて,タクロリムス(FK506)処理は,allo LTに対するGVT効果を阻害した。ドナー肝臓由来T/B細胞は肝臓外腫瘍を浸潤し,強いT細胞仲介免疫応答を誘発し,腫瘍免疫微小環境を改善する。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 腫瘍免疫 ,  T細胞 ,  インターロイキン10 ,  *複合体 ,  肝細胞癌 ,  *腫瘍 ,  ヒト ,  インターフェロンγ ,  TNFα ,  ケモカイン ,  *肝臓移植 ,  インターロイキン4 ,  ドナー【臓器移植】 ,  *移植片
準シソーラス用語： 微小環境 ,  悪性腫瘍 , 【Automatic Indexing@JST】

分類 (1件)： 消化器疾患の外科療法  (GH05030R)

タイトルに関連する用語 (3件)： マウス ,  肝移植 ,  移植片対腫瘍効果