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J-GLOBAL ID：201902246716229007   整理番号：19A2237086

中年および高齢中国人集団における血清炭水化物抗原125レベルおよび2型糖尿病の発症リスク:Dongfeng-Tongjiコホート研究【JST・京大機械翻訳】

Serum carbohydrate antigen 125 levels and incident risk of type 2 diabetes mellitus in middle-aged and elderly Chinese population: The Dongfeng-Tongji cohort study

著者 (15件)： Yu Caizheng (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yu Caizheng (Department of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Lei Qing (Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wang Jing (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Han Xu (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wang Fei (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yuan Jing (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yao Ping (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wei Sheng (Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wang Youjie (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Liang Yuan (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Zhang Xiaomin (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Guo Huan (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yang Handong (Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, China) ,  He Meian (Department of Occupational and Environmental Health and State Key Laboratory of Environmental and Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China)
資料名： Diabetes and Vascular Disease Research  (Diabetes and Vascular Disease Research)
巻： 16  号： 5  ページ： 424-430  発行年： 2019年 
JST資料番号： W5195A  ISSN： 1479-1641  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 目的:本研究の目的は,前向きコホートにおける血清炭水化物抗原125濃度と2型糖尿病リスクの間の関連を調査することであった。【方法】2008年9月~2010年6月にDongfeng-Tongjiコホートから得られた63.1歳の18983人の適格参加者を対象とし,それらを2013年10月まで追跡した。Cox比例ハザードモデルを用いて,炭水化物抗原125濃度に関連した2型糖尿病発生のハザード比と95%信頼区間を推定した。【結果】:すべてにおいて,2型糖尿病の1594の入射症例が4.6年の追跡調査の中央値の後に観察された。炭水化物抗原125濃度は,分布の四分位数に従って4群に分類された:<1.1,1.1~5.6,5.6~10.0および≧10U/mL。最も低い四分位の参加者と比較して,2型糖尿病のハザード比(95%信頼区間)は0.97(0.81~1.15),1.23(1.05~1.45)および1.48(1.27~1.74)であった。炭水化物抗原125レベルの標準偏差増加により,2型糖尿病のハザード比は12%(95%信頼区間,8~16)増加した。結論:本研究からの知見は,血清炭水化物抗原125濃度が中年および高齢中国人集団の間の2型糖尿病リスクと正の相関があることを示した。Copyright The Author(s) 2019 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 前向きコホート研究 ,  コホート研究 ,  *2型糖尿病 ,  *抗原 ,  追跡調査 ,  信頼区間 ,  標準偏差 ,  *中年期 ,  *血清 ,  *母集団
準シソーラス用語： ハザード比 ,  比例ハザードモデル ,  *発症リスク ,  *中国人 , 【Automatic Indexing@JST】

著者キーワード (4件)： 血清炭水化物抗原125 ,  2型糖尿病 ,  発生率 ,  前向きコホート研究

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (10件)： 中年 ,  中国人 ,  集団 ,  血清 ,  炭水化物 ,  抗原 ,  2型糖尿病 ,  発症リスク ,  コホート ,  研究