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J-GLOBAL ID：201902255541241216   整理番号：19A1127555

IL1Rnは神経膠腫増殖に対するメチオニン欠乏の抑制効果を仲介する【JST・京大機械翻訳】

IL1RN mediates the suppressive effect of methionine deprivation on glioma proliferation

著者 (38件)： Wang Kaikai (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Wang Kaikai (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Liu Huailei (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Liu Huailei (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Liu Jiaqi (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Liu Jiaqi (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Wang Xiaoxiong (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Wang Xiaoxiong (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Teng Lei (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Teng Lei (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Jun (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Jun (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Liu Yi (Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA) ,  Yao Yizheng (Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA) ,  Wang Jun (Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA) ,  Qu Yuan (Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA) ,  Chen Xin (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Chen Xin (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Peng Fei (Department of Neurosurgery, The Second Affiliated Hospital and Institute of Neurosciences of Guangzhou Medical University, Guangzhou, 510260, China) ,  Liu Hongbo (College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China) ,  Wang Ning (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Wang Ning (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhong Yingqiang (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhong Yingqiang (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Hou Xu (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Hou Xu (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Jiang Haiping (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Jiang Haiping (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Beylerli Ozal (Bashkir State Medical University, Ufa, 450008, Russia) ,  Liao Xiang (Department of Medical Imaging, General Hospital of Nanjing Military Area Command, Nanjing, 210002, Jiangsu Province, China) ,  Zhang Xinjian (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Xinjian (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Xu (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Xu (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Xiangtong (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhang Xiangtong (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhao Shiguang (Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China) ,  Zhao Shiguang (Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China)
資料名： Cancer Letters  (Cancer Letters)
巻： 454  ページ： 146-157  発行年： 2019年 
JST資料番号： E0606B  ISSN： 0304-3835  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 代謝異常は癌細胞の特徴の1つであり,材料供給の制限は癌治療の潜在的なブレークスルーアプローチである。IDH1の有意性がグリオーマで確認されたので,研究者の増加はグリオーマ細胞代謝再プログラミングの研究に関与している。しかしながら,メチオニン枯渇により誘導される代謝再プログラミングの基礎となる分子機構は,グリオーマ細胞増殖を調節する。ここでは,メチオニン枯渇がin vitroおよびin vivoでインターロイキン1受容体拮抗剤(IL1RN)のダウンレギュレーションを介しグリオーマ細胞増殖を阻害することを示した。さらに,IL1RNは腫瘍関連遺伝子であり,その発現はグリオーマ患者の生存期間と負に相関することを確認した。これらの結果は,メチオニン枯渇/IL1RN関連遺伝子療法のようなアミノ酸代謝を標的とする強い理論的洞察が,グリオーマ治療のための新しい方向を提供する可能性があることを示している。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 代謝異常 ,  遺伝子療法 ,  ヒト ,  腫瘍細胞 ,  アミノ酸代謝 ,  *神経膠腫 ,  ダウンレギュレーション ,  in vitro実験 ,  代謝 ,  脂肪族アミン ,  スルフィド ,  脂肪族カルボン酸 ,  含硫アミノ酸 ,  第一アミン
準シソーラス用語： アンタゴニスト ,  グリオーマ細胞 ,  分子機構 ,  リプログラミング ,  細胞代謝 ,  癌治療 , 【Automatic Indexing@JST】

著者キーワード (5件)： 神経膠腫 ,  IL1Rn ,  代謝リプログラミング ,  腫瘍関連遺伝子 ,  遺伝子治療

分類 (1件)： 腫ようの化学・生化学・病理学  (GE02030N)

物質索引 (1件)： メチオニン

タイトルに関連する用語 (6件)： 神経膠腫 ,  増殖 ,  メチオニン ,  欠乏 ,  抑制効果 ,  仲介