文献

J-GLOBAL ID：201902257075594968   整理番号：19A1898587

進行前立腺癌における臨床転帰のゲノム相関【JST・京大機械翻訳】

Genomic correlates of clinical outcome in advanced prostate cancer

著者 (58件)： Abida Wassim (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Cyrta Joanna (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  Cyrta Joanna (Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland) ,  Heller Glenn (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Prandi Davide (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy) ,  Armenia Joshua (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Coleman Ilsa (Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109) ,  Cieslik Marcin (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Benelli Matteo (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy) ,  Robinson Dan (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Van Allen Eliezer M. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215) ,  Van Allen Eliezer M. (Broad Institute, Cambridge, MA 02142) ,  Sboner Andrea (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  Fedrizzi Tarcisio (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy) ,  Mosquera Juan Miguel (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  Robinson Brian D. (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  De Sarkar Navonil (Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109) ,  Kunju Lakshmi P. (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Tomlins Scott (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Wu Yi Mi (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Nava Rodrigues Daniel (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Nava Rodrigues Daniel (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Loda Massimo (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  Loda Massimo (Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215) ,  Gopalan Anuradha (Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Reuter Victor E. (Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Pritchard Colin C. (Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109) ,  Mateo Joaquin (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Mateo Joaquin (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Bianchini Diletta (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Bianchini Diletta (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Miranda Susana (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Miranda Susana (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Carreira Suzanne (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Carreira Suzanne (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Rescigno Pasquale (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  Rescigno Pasquale (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Filipenko Julie (Prostate Cancer Clinical Trials Consortium, New York, NY 10065) ,  Vinson Jacob (Prostate Cancer Clinical Trials Consortium, New York, NY 10065) ,  Montgomery Robert B. (Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109) ,  Beltran Himisha (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215) ,  Beltran Himisha (Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021) ,  Heath Elisabeth I. (Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201) ,  Heath Elisabeth I. (Department of Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201) ,  Scher Howard I. (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Kantoff Philip W. (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Taplin Mary-Ellen (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215) ,  Schultz Nikolaus (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  deBono Johann S. (Institute of Cancer Research, London SW7 3RP, United Kingdom) ,  deBono Johann S. (The Royal Marsden National Health Service Foundation Trust, London SM2 5NG, United Kingdom) ,  Demichelis Francesca (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy) ,  Nelson Peter S. (Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109) ,  Rubin Mark A. (Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021) ,  Rubin Mark A. (Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland) ,  Chinnaiyan Arul M. (Department of Pathology, University of Michigan, Ann Arbor, MI 48109) ,  Chinnaiyan Arul M. (Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109) ,  Sawyers Charles L. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065) ,  Sawyers Charles L. (Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065)
資料名： Proceedings of the National Academy of Sciences of the United States of America  (Proceedings of the National Academy of Sciences of the United States of America)
巻： 116  号： 23  ページ： 11428-11436  発行年： 2019年 
JST資料番号： D0387A  ISSN： 0027-8424  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 転移性前立腺癌のゲノム景観における不均一性は,いくつかの包括的プロファイリング努力を通して明らかになっているが,臨床転帰に対するこの不均一性の影響についてはほとんど知られていない。ここでは,長期臨床転帰と関連した転移性去勢抵抗性前立腺癌(mCRPC)患者429名の包括的ゲノムおよびトランスクリプトーム解析を報告し,全エキソソーム,トランスクリプトームおよび組織学的分析からの知見を統合した。第一ライン次世代アンドロゲン受容体シグナル伝達阻害剤(Arsi;アビラテロンまたはベンズアルタミド)で治療した128名の患者について,アンドロゲン受容体(AR)変異体発現,AR転写出力および神経内分泌発現特徴を含む18の再発DNAおよびRNAに基づくゲノム変化と臨床転帰との関連を検討した。これらのうち,RB1の変化のみが生存不良と有意に関連していたが,RB1,ARおよびTP53の変化はArsi処理により短い時間と関連していた。組織学および臨床転帰とmCRPCゲノミクスを統合したこの大規模解析は,RB1ゲノム変化を不良転帰の強力な予測因子として同定し,臨床および分子関連のさらなる研究のためのコミュニティ資源である。Copyright 2019 The Author(s). Published by PNAS. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *ゲノム ,  細胞情報伝達 ,  コミュニティ ,  トランスクリプトーム ,  アンドロゲン受容体 ,  *前立腺腫瘍 ,  RNA【核酸】 ,  再発 ,  ヒト ,  DNA【核酸】
準シソーラス用語： ゲノミクス ,  TP53 ,  阻害剤 ,  エキソソーム ,  プロファイリング ,  *転帰 , 【Automatic Indexing@JST】

著者キーワード (4件)： 去勢抵抗性前立腺癌 ,  統合ゲノミクス ,  臨床転帰 ,  バイオマーカー

分類 (1件)： 遺伝子発現  (EC02040Q)

タイトルに関連する用語 (4件)： 前立腺癌 ,  臨床転帰 ,  ゲノム ,  相関