文献

J-GLOBAL ID：201902262307778822   整理番号：19A1636044

塩基性ヘリックス-ループ-ヘリックス転写因子Twist1は乳癌における前勾配蛋白質2ホモログ(AGR2)の新規調節因子である【JST・京大機械翻訳】

Basic helix-loop-helix transcription factor Twist1 is a novel regulator of anterior gradient protein 2 homolog (AGR2) in breast cancer

著者 (30件)： Jung Seok Yun (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Jung Seok Yun (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Yun Jisoo (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Yun Jisoo (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Kim Seong Jang (Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea) ,  Kang Songhwa (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Kang Songhwa (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Kim Da Yeon (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Kim Da Yeon (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Kim Yeon Ju (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Kim Yeon Ju (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Park Ji Hye (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Park Ji Hye (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Jang Woong Bi (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Jang Woong Bi (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Ji Seung Taek (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Ji Seung Taek (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Ha Jong Seong (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Ha Jong Seong (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Hong Van Le Thi (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Hong Van Le Thi (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Truong Giang Ly Thanh (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Truong Giang Ly Thanh (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Rethineswaran Vinoth Kumar (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Rethineswaran Vinoth Kumar (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Kim Dong Hwan (Department of Neurosurgery and Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea) ,  Song Parkyong (Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea) ,  Kwon Sang-Mo (Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea) ,  Kwon Sang-Mo (Convergence Stem Cell Research Center, Pusan National University, Yangsan, Republic of Korea) ,  Kwon Sang-Mo (Research Institute of Convergence Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea)
資料名： Biochemical and Biophysical Research Communications  (Biochemical and Biophysical Research Communications)
巻： 516  号： 1  ページ： 149-156  発行年： 2019年 
JST資料番号： B0118A  ISSN： 0006-291X  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 前勾配蛋白質2ホモログ(AGR2)は小胞体蛋白質のジスルフィドイソメラーゼファミリーに属する。炎症は,前立腺,肺および膵臓の腫瘍を含むいくつかのタイプの固形腫瘍で過剰発現した。しかしながら,乳癌におけるAGR2の役割とAGR2蛋白質発現の基礎となる調節機構は完全に理解されていない。著者らは,AGR2レベルが低酸素条件下および乳癌腫瘍において増加することを示した。機構的に,Twist1はEボックス配列を介してAGR2プロモーターを結合し活性化する。低酸素条件下では,Twist1レベルがshRNAにより低下すると,ARG2の発現増加は減弱した。逆に,Twist1過剰発現はHIF-1αノックダウンによりAGR2レベルを完全に逆転させた。特に,AGR2は乳癌細胞のTwist1誘導増殖,遊走および浸潤に必要である。まとめると,これらの知見は乳癌におけるAGR2調節の理解を拡大し,乳癌に対するTwist1-AGR2標的治療の開発に寄与する可能性がある。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： プロモーター領域 ,  *転写因子 ,  イソメラーゼ ,  酸素欠乏 ,  炎症 ,  *乳房腫瘍 ,  ジスルフィド ,  *タンパク質
準シソーラス用語： 遊走 ,  遺伝子ノックダウン法 ,  低分子ヘアピンRNA ,  蛋白質発現 ,  過剰発現 ,  *ホモログ ,  *Twist1 , 【Automatic Indexing@JST】

著者キーワード (4件)： 前勾配蛋白質2ホモログ(AGR2) ,  ねじれ関連蛋白質1(Twist1) ,  Eボックス配列 ,  乳癌

分類 (2件)： 遺伝子の構造と化学  (EC02020U) ,  微生物の生化学  (EG03020N)

タイトルに関連する用語 (10件)： 塩基性 ,  ヘリックス ,  ループ ,  転写因子 ,  Twist1 ,  乳癌 ,  勾配 ,  蛋白質 ,  ホモログ ,  調節因子