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J-GLOBAL ID：201902267108421043   整理番号：19A0815645

腫瘍代謝標識と標的イメージングのためのポリイン架橋赤色発光AIEGENに基づくバイオ直交AIEドット【JST・京大機械翻訳】

Bio-orthogonal AIE Dots Based on Polyyne-Bridged Red-emissive AIEgen for Tumor Metabolic Labeling and Targeted Imaging

著者 (17件)： Zhang Pengfei (HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-Tech Park, Nanshan, Shenzhen, 518057, China) ,  Zhang Pengfei (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...) ,  Zhang Pengfei (Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China) ,  Jiang Tao (HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-Tech Park, Nanshan, Shenzhen, 518057, China) ,  Jiang Tao (Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China) ,  Jiang Tao (Department of Pharmaceutical Sciences, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, P.R. China) ,  Li Yuanyuan (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...) ,  Zhao Zheng (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...) ,  Gong Ping (Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China) ,  Cai Lintao (Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China) ,  Kwok Ryan T. K. (HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-Tech Park, Nanshan, Shenzhen, 518057, China) ,  Kwok Ryan T. K. (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...) ,  Lam Jacky Wing Yip (HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-Tech Park, Nanshan, Shenzhen, 518057, China) ,  Lam Jacky Wing Yip (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...) ,  Gu Xinggui (Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China) ,  Tang Ben Zhong (HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-Tech Park, Nanshan, Shenzhen, 518057, China) ,  Tang Ben Zhong (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Ko...)
資料名： Chemistry. Asian Journal  (Chemistry. Asian Journal)
巻： 14  号： 6  ページ： 770-774  発行年： 2019年 
JST資料番号： W1856A  ISSN： 1861-4728  CODEN： CAAJBI  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 本研究では,代謝工学とバイオ直交反応の組合せにより,ポリイン架橋赤色発光AIEgen,2TPE-4Eに基づく癌細胞標的AIEドットを開発することを目的とした。腫瘍上のアジド基は,Ac4ManNAzとグリコール代謝工学の静脈注射により効率的に産生された。これらのバイオ直交アジド基は,in vivoでの無金属クリック反応を受ける腫瘍細胞へのDBCO-AIEドットの特異的標的化を容易にすることができた。この標的化戦略の効率は,より高い反応性を有する新しいバイオ直交化学基の開発によりさらに改善され,大量のAIEgensを診断のために腫瘍に送達することができた。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *画像処理 ,  ターゲティング ,  アジド ,  *腫瘍 ,  腫瘍細胞 ,  反応性 ,  *代謝 ,  *直交性
準シソーラス用語： クリック化学 ,  静脈内注射 ,  代謝工学 ,  *赤色発光 , 【Automatic Indexing@JST】

著者キーワード (5件)： 凝集誘起発光 ,  バイオ直交化学 ,  癌 ,  代謝標識 ,  腫瘍

分類 (3件)： トリアゾール  (CF07084O) ,  抗腫よう薬の基礎研究  (GW16010A) ,  アルキン  (CF03040E)

タイトルに関連する用語 (9件)： 腫瘍 ,  代謝 ,  標識 ,  標的 ,  イメージング ,  ポリイン ,  架橋 ,  赤色発光 ,  ドット