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J-GLOBAL ID：201902268698602311   整理番号：19A1398927

喘息の混合小児における吸入コルチコステロイド反応のゲノムワイド関連研究【JST・京大機械翻訳】

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

著者 (61件)： Hernandez-Pacheco Natalia (Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, San Cristobal de La Laguna, Spain) ,  Hernandez-Pacheco Natalia (Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristobal de La Laguna, Santa Cruz de Tenerife, Spain) ,  Farzan Niloufar (Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands) ,  Farzan Niloufar (Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, Netherlands) ,  Francis Ben (Department of Women’s and Children’s Health, University of Liverpool, Liverpool, UK) ,  Karimi Leila (Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands) ,  Repnik Katja (Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia) ,  Repnik Katja (Laboratory for Biochemistry, Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia) ,  Vijverberg Susanne J. (Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands) ,  Vijverberg Susanne J. (Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, Netherlands) ,  Soares Patricia (Academic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children’s Hospital, Brighton, UK) ,  Schieck Maximilian (Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO), Regensburg, Germany) ,  Schieck Maximilian (Department of Human Genetics, Hannover Medical School, Hannover, Germany) ,  Gorenjak Mario (Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia) ,  Forno Erick (Division of Pediatric Pulmonary Medicine, Children’s Hospital of Pittsburgh of the University of Pittsburgh, Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania) ,  Eng Celeste (Department of Medicine, University of California, San Francisco, California) ,  Oh Sam S. (Department of Medicine, University of California, San Francisco, California) ,  Perez-Mendez Lina (Department of Clinic Epidemiology and Biostatistics, Research Unit, Hospital Universitario N.S. de Candelaria, Gerencia de Atencion Primaria, Santa Cruz de Tenerife, Spain) ,  Perez-Mendez Lina (CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain) ,  Berce Vojko (Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia) ,  Berce Vojko (Department of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia) ,  Tavendale Roger (Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK) ,  Samedy Lesly-Anne (Department of Medicine, University of California, San Francisco, California) ,  Samedy Lesly-Anne (Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California) ,  Hunstman Scott (Department of Medicine, University of California, San Francisco, California) ,  Hu Donglei (Department of Medicine, University of California, San Francisco, California) ,  Meade Kelley (Children’s Hospital and Research Center Oakland, Oakland, California) ,  Farber Harold J. (Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas) ,  Avila Pedro C. (Department of Medicine, Northwestern University, Chicago, Illinois) ,  Avila Pedro C. (Allergy & ENT Associates, The Woodland, Texas) ,  Serebrisky Denise (Pediatric Pulmonary Division, New York, NY) ,  Thyne Shannon M. (Department of Pediatrics, University of California, San Francisco, California) ,  Brigino-Buenaventura Emerita (Department of Allergy and Immunology, Vallejo, California) ,  Rodriguez-Cintron William (Veterans Caribbean Health Care System, San Juan, Puerto Rico) ,  Sen Saunak (University of Tennessee Health Science Center, Memphis, Tennessee) ,  Kumar Rajesh (Feinberg School of Medicine’s Division of Allergy and Immunology, Northwestern University, Chicago, Illinois) ,  Kumar Rajesh (Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois) ,  Lenoir Michael (Bay Area Pediatrics, Oakland, California) ,  Rodriguez-Santana Jose R. (Centro de Neumologia Pediatrica, San Juan, Puerto Rico) ,  Celedon Juan C. (Division of Pediatric Pulmonary Medicine, Children’s Hospital of Pittsburgh of the University of Pittsburgh, Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania) ,  Mukhopadhyay Somnath (Academic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children’s Hospital, Brighton, UK) ,  Mukhopadhyay Somnath (Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK) ,  Potocnik Uros (Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia) ,  Potocnik Uros (Laboratory for Biochemistry, Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia) ,  Pirmohamed Munir (Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK) ,  Verhamme Katia M. (Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands) ,  Kabesch Michael (Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO), Regensburg, Germany) ,  Palmer Colin N. A. (Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK) ,  Hawcutt Daniel B. (Department of Women’s and Children’s Health, University of Liverpool, Liverpool, UK) ,  Hawcutt Daniel B. (Alder Hey Children’s Hospital, Liverpool, UK) ,  Flores Carlos (Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, San Cristobal de La Laguna, Spain) ,  Flores Carlos (CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain) ,  Flores Carlos (Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), Santa Cruz de Tenerife, Spain) ,  Maitland-van der Zee Anke H. (Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands) ,  Maitland-van der Zee Anke H. (Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, Netherlands) ,  Maitland-van der Zee Anke H. (Department of Pediatric Respiratory Medicine and Allergy, Emma’s Children Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands) ,  Burchard Esteban G. (Department of Medicine, University of California, San Francisco, California) ,  Burchard Esteban G. (Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California) ,  Pino-Yanes Maria (Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, San Cristobal de La Laguna, Spain) ,  Pino-Yanes Maria (Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristobal de La Laguna, Santa Cruz de Tenerife, Spain) ,  Pino-Yanes Maria (CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain)
資料名： Clinical & Experimental Allergy  (Clinical & Experimental Allergy)
巻： 49  号： 6  ページ： 789-798  発行年： 2019年 
JST資料番号： T0205A  ISSN： 0954-7894  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景:吸入コルチコステロイド(ICS)は喘息症状と悪化を制御するために最も広く処方され,効果的な薬物療法である。しかしながら,多くの小児は治療にもかかわらず,特にPuerto Ricansやアフリカ系アメリカ人のような混合集団において喘息悪化を有している。ヨーロッパおよびアジアの個体群において,いくつかのゲノムワイド関連研究(GWAS)が実施されており,ICS応答における遺伝的成分の重要性を示している。目的:ICSで治療し,以前のGWAS所見を検証するために,喘息悪化に関連した遺伝的変異体を同定することを目的とした。【方法】喘息悪化の2つのGWASのメタ分析を,ICS(ヒスパニック/ラテンスとアフリカ系アメリカ人)で治療された1347人の混合小児において実行し,8.7百万の遺伝的変異体を分析した。P≦5×10~6の患者は,6つのヨーロッパの研究からの1697人の喘息患者における複製のために追跡された。公表されたGWASにおいて記述されたICS応答の関連を,混合集団における複製のために追跡した。結果:合計15の独立した変異体は,混合集団(P≦5×10~-6)における喘息悪化と関連していた。APOBEC3BおよびAPOBEC3Cの遺伝子間領域に位置するそれらのうちの1つは,ヨーロッパ人における複製の証拠を示し(rs5995653,P=7.52×10-3),ICS処理後の肺機能の変化とも関連していた(P=4.91×10-3)。さらに,L3MBTL4-ARHGAP28ゲノム領域の報告された関連は,異なる変異体が同定されたが,混合集団において確認された。結論:本研究は,ICSで治療され,以前に同定されたゲノム領域を複製した小児において,APOBEC3BとAPOBEC3Cと喘息増悪との新しい関連性を明らかにした。これは,このような治療に反応できない喘息患者の臨床的同定を可能にするICSに対する反応性を決定する複数の遺伝的マーカーに関する現在の知識に寄与する。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 薬物療法 ,  遺伝 ,  ヨーロッパ ,  *喘息 ,  *子供 ,  メタ分析 ,  *ゲノム ,  アフリカ ,  ヒト ,  個体群 ,  アジア ,  ゲノムワイド関連解析
準シソーラス用語： ヒスパニック ,  喘息増悪 ,  アフリカ系アメリカ人 ,  *吸入ステロイド , 【Automatic Indexing@JST】

著者キーワード (5件)： アフリカ系アメリカ ,  小児喘息 ,  増悪 ,  ラテン ,  薬理ゲノミクス

分類 (1件)： 呼吸器の疾患  (GI03000Z)

タイトルに関連する用語 (5件)： 喘息 ,  小児 ,  吸入コルチコステロイド ,  ゲノム ,  研究