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J-GLOBAL ID：201902281031201259   整理番号：19A2431232

新規p97/VCP阻害剤は,ボルテゾミブ感受性および耐性多発性骨髄腫細胞の両方で小胞体ストレスおよびアポトーシスを誘導する

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells

著者 (16件)： Nishimura Nao (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Radwan Mohamed O. (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Radwan Mohamed O. (Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, Egypt) ,  Amano Masayuki (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Endo Shinya (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Fujii Eri (Faculty of Medical Sciences, Division of Informative Clinical Sciences, Kumamoto University, Kumamoto, Japan) ,  Hayashi Hironori (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Ueno Shikiko (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Ueno Niina (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Tatetsu Hiro (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Hata Hiroyuki (Faculty of Medical Sciences, Division of Informative Clinical Sciences, Kumamoto University, Kumamoto, Japan) ,  Okamoto Yoshinari (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Otsuka Masami (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Mitsuya Hiroaki (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Matsuoka Masao (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Okuno Yutaka (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 110  号： 10  ページ： 3275-3287  発行年： 2019年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： p97/VCPは,AAA(細胞活性関連ATPアーゼ)ATPア...

シソーラス用語： 培養細胞 ,...
準シソーラス用語： 細胞生理 ,...

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著者キーワード (5件)： アポトーシス ,  ERAD ,  骨髄腫 ,  OSSL_320596 ,  p97/VCP

分類 (1件)： 抗腫よう薬の基礎研究  (GW16010A)

物質索引 (1件)： OSSL_325096

タイトルに関連する用語 (11件)： p97 ,  VCP ,  阻害剤 ,  ボルテゾミブ ,  感受性 ,  耐性 ,  多発性骨髄腫 ,  細胞 ,  小胞体ストレス ,  アポトーシス ,  誘導