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J-GLOBAL ID：201902282836193342   整理番号：19A2681629

抗癌剤デリバリーデポとしての脂肪細胞【JST・京大機械翻訳】

Adipocytes as Anticancer Drug Delivery Depot

著者 (36件)： Wen Di (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wen Di (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wen Di (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Wang Jinqiang (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wang Jinqiang (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wang Jinqiang (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Van Den Driessche George (Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA) ,  Chen Qian (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Chen Qian (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Chen Qian (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Zhang Yuqi (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Zhang Yuqi (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Zhang Yuqi (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Chen Guojun (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Chen Guojun (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Chen Guojun (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Li Hongjun (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Li Hongjun (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Soto Jennifer (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Soto Jennifer (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Liu Ming (Department of Physics, North Carolina State University, Raleigh, NC 27695, USA) ,  Ohashi Masao (Department of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wang Zejun (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Wang Zejun (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Abdou Peter (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Abdou Peter (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Hu Quanyin (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Hu Quanyin (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Hu Quanyin (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA) ,  Dotti Gianpietro (Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA) ,  Li Song (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Li Song (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Fourches Denis (Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA) ,  Gu Zhen (Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Gu Zhen (Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA) ,  Gu Zhen (Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA)
資料名： Matter  (Matter)
巻： 1  号： 5  ページ： 1203-1214  発行年： 2019年 
JST資料番号： W5534A  ISSN： 2590-2385  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 腫瘍関連脂肪細胞はエネルギーを供給し,慢性炎症を引き起こすことにより腫瘍増殖を促進する。ここでは,腫瘍部位で癌治療をデリバーするためのデポとして機能する,脂肪細胞を,脂質代謝を利用した。抗癌性脂肪酸としてのルメニン酸(RA)と活性酸素種(ROS)切断可能リンカーを有するドキソルビシンプロドラッグ(PdOx)は,腫瘍特異的生物応答性様式で治療を提供するために脂肪細胞にカプセル化される。腫瘍内または術後投与後,脂肪分解は細胞内ROS応答性転換により活性化されるRAとPdOxを放出し,その後抗腫瘍効果を促進する。さらに,PD-L1発現のダウンレギュレーションは腫瘍細胞において観察され,CD4+およびCD8+T細胞仲介免疫応答の出現に好都合である。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 腫瘍細胞 ,  *脂肪細胞 ,  脂肪酸 ,  河川 ,  抗腫瘍作用 ,  ダウンレギュレーション ,  腫瘍 ,  *抗腫瘍薬 ,  免疫反応
準シソーラス用語： CD8陽性T細胞 ,  CD4陽性細胞 ,  術後投与 ,  腫瘍発生部位 ,  慢性炎症 , 【Automatic Indexing@JST】

著者キーワード (5件)： MAP4:実証 ,  腫瘍関連脂肪細胞 ,  脂質代謝 ,  化学療法 ,  免疫療法

分類 (2件)： 腫よう免疫  (ED03040A) ,  腫ようの実験的治療  (GE02040Y)

タイトルに関連する用語 (3件)： 抗癌剤 ,  デリバリー ,  脂肪細胞