文献

J-GLOBAL ID：201902283740088119   整理番号：19A2348699

ミクロビオームと結核:技術の現状,潜在的応用,および臨床研究課題の定義【JST・京大機械翻訳】

The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda

著者 (20件)： Naidoo Charissa C (Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Naidoo Charissa C (South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Naidoo Charissa C (Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Naidoo Charissa C (African Microbiome Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Nyawo Georgina R (Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Nyawo Georgina R (South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Nyawo Georgina R (Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Nyawo Georgina R (African Microbiome Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Wu Benjamin G (Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY, USA) ,  Walzl Gerhard (Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Walzl Gerhard (South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Walzl Gerhard (Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Warren Robin M (Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Warren Robin M (South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Warren Robin M (Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Segal Leopoldo N (Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY, USA) ,  Theron Grant (Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Theron Grant (South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Theron Grant (Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa) ,  Theron Grant (African Microbiome Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa)
資料名： Lancet Respiratory Medicine  (Lancet Respiratory Medicine)
巻： 7  号： 10  ページ： 892-906  発行年： 2019年 
JST資料番号： W3111A  ISSN： 2213-2600  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 我々の体内の多様な微生物群集は宿主免疫応答を調節する代謝産物を産生する。遠位部位におけるミクロビオームでも呼吸器健康において重要な機能を有する。しかしながら,世界的に死亡の最大の感染原因である結核におけるミクロビオームの臨床的重要性は,理解され始めているだけである。ここでは,肺結核とのマイクロバイオームの関連に関する研究を批判的にレビューする。研究は5つの主要点を示す。(1)感染に対する感受性と活性結核への進行は腸内Helicobacter co感染により変化し,(2)エアロゾルMycobacterium tuberculosis感染は腸内微生物叢を変化させ,(3)肺における経口嫌気性は肺免疫を低下させ,進行を予測する。(4)結核治療に必要な長期抗生物質治療は微生物に対する長期的有害作用を有する。知識ギャップを強調し,これらの知識ギャップを扱うための考察を強調し,結核を制御するための微生物を修飾するための潜在的標的を記述した。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 結核菌 ,  *結核 ,  代謝産物 ,  Helicobacter ,  肺結核 ,  感受性 ,  治療法 ,  腸内微生物 ,  微生物 ,  呼吸器 ,  エアロゾル
準シソーラス用語： 有害作用 ,  健康 ,  微生物コンソーシアム ,  *常在菌叢ゲノム , 【Automatic Indexing@JST】

分類 (1件)： 呼吸器の疾患  (GI03000Z)

タイトルに関連する用語 (7件)： ミクロビオーム ,  結核 ,  現状 ,  応用 ,  臨床 ,  研究 ,  定義