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J-GLOBAL ID：201902287635975392   整理番号：19A1182547

環状RNAの構造と分解は自然免疫におけるPKR活性化を調節する【JST・京大機械翻訳】

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

著者 (20件)： Liu Chu-Xiao (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Li Xiang (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Nan Fang (CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200...) ,  Jiang Shan (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Gao Xiang (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Gao Xiang (School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China) ,  Guo Si-Kun (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Xue Wei (CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200...) ,  Cui Yange (Laboratory of Molecular Rheumatology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China) ,  Dong Kaige (CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200...) ,  Ding Huihua (Shanghai Institute of Rheumatology, China-Australia Centre for Personalized Immunology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Qu Bo (Shanghai Institute of Rheumatology, China-Australia Centre for Personalized Immunology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Zhou Zhaocai (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Shen Nan (Laboratory of Molecular Rheumatology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China) ,  Shen Nan (Shanghai Institute of Rheumatology, China-Australia Centre for Personalized Immunology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Shen Nan (Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Yang Li (CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200...) ,  Yang Li (School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China) ,  Chen Ling-Ling (State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Sh...) ,  Chen Ling-Ling (School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 177  号： 4  ページ： 865-880.e21  発行年： 2019年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： プレmRNAのエキソンのバックスプライシングから産生される環状RNA(circRNA)は広く発現されているが,それらの機能の現在の理解は限られている。これらのRNAは一般的に安定で,それらの線形RNA同族体とは異なる独特の構造的立体配座を持つと考えられている。ここでは,内在性circRNAが16~26bp不完全RNA二本鎖を形成し,自然免疫に関連する二本鎖RNA(dsRNA)活性化蛋白質キナーゼ(PKR)の阻害剤として作用することを示した。ポリ(I:C)刺激またはウイルス感染において,circRNAは初期細胞自然免疫応答におけるPKR活性化に必要な過程であるRNアーゼLにより全体的に分解される。自己免疫性疾患全身性エリテマトーデス(SLE)患者に由来する末梢血単核細胞(PBMC)において,増強されたPKRリン酸化とcircRNA減少が見出される。重要なことに,SLEから誘導されたPBMCまたはT細胞におけるdsRNAを含むcircRNAの過剰発現は,異常なPKR活性化カスケードを軽減することができ,したがって,circRNAとSLEの間の結合を提供する。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ウイルス感染 ,  リン酸化 ,  T細胞 ,  全身性エリテマトーデス ,  タンパク質キナーゼ ,  立体配座 ,  *自然免疫 ,  mRNA ,  二本鎖RNA ,  *RNA【核酸】
準シソーラス用語： 過剰発現 ,  末梢血単核細胞 ,  RNアーゼL ,  阻害剤 ,  *環状RNA , 【Automatic Indexing@JST】

著者キーワード (10件)： 環状RNA ,  CircRNA ,  CircRNA構造 ,  CircRNA分解 ,  二本鎖RNA ,  RNアーゼL ,  PKR ,  自然免疫応答 ,  自己免疫疾患 ,  全身性エリテマトーデス

分類 (1件)： 分子構造  (EB03020Y)

タイトルに関連する用語 (6件)： 環状RNA ,  分解 ,  自然免疫 ,  PKR ,  活性化 ,  調節