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J-GLOBAL ID：201902288835717184   整理番号：19A0080901

効率的な肝臓再集団能力を有する初代ヒト肝細胞のin vitro増殖【JST・京大機械翻訳】

In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

著者 (25件)： Zhang Kun (Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China) ,  Zhang Kun (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhang Ludi (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Liu Wenming (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Ma Xiaolong (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Cen Jin (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Sun Zhen (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Sun Zhen (School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China) ,  Wang Chenhua (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Feng Sisi (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhang Zhengtao (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Yue Liyun (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Sun Lulu (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhu Zhenfeng (Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China) ,  Chen Xiaotao (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Feng Anqi (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Wu Jiaying (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Jiang Zhiwu (Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China) ,  Li Peng (Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China) ,  Cheng Xin (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Gao Dong (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Peng Luying (Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China) ,  Hui Lijian (State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Hui Lijian (School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China) ,  Hui Lijian (Stem Cell and Regenerative Medicine Innovation Academy, Beijing 100101, China)
資料名： Cell Stem Cell  (Cell Stem Cell)
巻： 23  号： 6  ページ： 806-819.e4  発行年： 2018年 
JST資料番号： W3106A  ISSN： 1934-5909  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： ヒト肝細胞(HH)の移植は,肝疾患を治療するための有意な可能性を有する。しかしながら,移植可能なHHsの供給は,限られたドナーの利用可能性とin vitroでの拡大に対する能力の低下により厳しく制約されている。慢性傷害に応答して,いくつかのHHは肝細胞と前駆細胞の両方を発現する増殖細胞に再プログラムされ,in vitroでのHHsの拡大のための爆発的戦略を示唆する。ここでは,HHsの10000倍の拡大を可能にする定義された媒体条件を報告する。これらの増殖性HHsは二型表現型で,部分的に肝臓の特徴を保持しているが,子孫関連遺伝子の発現を獲得している。重要なことに,これらの細胞は初代HHに匹敵するレベルで損傷マウス肝臓に移植され,それらはin vivoでの移植またはin vitroでの分化後に成熟を受ける。したがって,本研究は,移植可能なHHsの大規模な拡大を可能にするプロトコルを提供する。それは,ヒト肝疾患のモデリングと治療のためにさらに開発されることができる。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *in vitro実験 ,  表現型 ,  *ヒト ,  *肝細胞 ,  肝臓疾患 ,  媒質 ,  ドナー ,  遺伝子 ,  マウス ,  分化 ,  モデリング ,  ドナー【臓器移植】
準シソーラス用語： 前駆細胞 ,  慢性化 ,  *in vitro増殖 ,  *ヒト肝細胞 , 【Automatic Indexing@JST】

著者キーワード (4件)： 肝細胞移植 ,  肝細胞培養 ,  細胞可塑性 ,  肝再集団

分類 (2件)： 消化器の基礎医学  (GH01020E) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： 肝臓 ,  集団 ,  能力 ,  ヒト肝細胞 ,  増殖