樋口雄亮

ヒグチユウスケ | HIGUCHI YUSUKE

研究キーワード (4件)： CRISPRスクリーニング , 循環器疾患 , 遺伝子編集 , 代謝性疾患

競争的資金等の研究課題 (1件)：

論文 (26件)：

Naoki Maruyama, Takehiro Ogata, Takeru Kasahara, Tetsuro Hamaoka, Yusuke Higuchi, Yumika Tsuji, Shinya Tomita, Akira Sakamoto, Naohiko Nakanishi, Satoaki Matoba. Loss of Cavin-2 destabilizes PTEN and enhances Akt signaling pathway in cardiomyocytes. Cardiovascular research. 2024
Shinya Tomita, Naohiko Nakanishi, Takehiro Ogata, Yusuke Higuchi, Akira Sakamoto, Yumika Tsuji, Takaomi Suga, Satoaki Matoba. The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding. Communications biology. 2024. 7. 1. 40-40
Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Masahiro Nishi, Yumika Tsuji, Shinya Tomita, Simon J Conway, Satoaki Matoba. Cavin-2 promotes fibroblast-to-myofibroblast trans-differentiation and aggravates cardiac fibrosis. ESC heart failure. 2023
Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma, et al. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Science translational medicine. 2023. 15. 711. eadi2623
Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Shunsuke Kita, Yusuke Higuchi, Yuhei Kirita, Ryutaro Kotaki, Keisuke Tonouchi, et al. Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Nature communications. 2023. 14. 1. 4198-4198

MISC (15件)：

冨田伸也, 中西直彦, 小形岳寛, 菅孝臣, 辻弓佳, 酒本暁, 樋口雄亮, 的場聖明. Cavin-1 modulates BMP/Smad Signaling through the Interaction of Caveolin-1 with BMPRII in Pulmonary Artery Endothelial Cells(和訳中). 日本循環器学会学術集会抄録集. 2021. 85回. OJ82-3
Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Akira Sakamoto, Yumika Tsuji, Shinya Tomita, Satoaki Matoba. Cavin-2 Deletion Attenuates Fibroblast Activation and Cardiac Fibrosis via TGF-beta Signaling by Interacting With Hsp90. CIRCULATION RESEARCH. 2020. 127
Yusuke Higuchi, Takehiro Ogata, Masahiro Nishi, Naohiko Nakanishi, Akira Sakamoto, Yumika Tsuji, Satoaki Matoba. Cavin-2/SDPR in cardiac fibroblasts regulates cardiac fibrosis and function via TGF-beta/Smad signaling in pressure-overloaded hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2020. 140. 17-17
Yusuke Higuchi, Takehiro Ogata, Akira Sakamoto, Naohiko Nakanishi, Yumika Tsuji, Shinya Tomita, Satoaki Matoba. SDPR/Cavin-2 Regulates Adipocyte Differentiation With Suppression of PPAR. and C/EBP alpha Expressions in 3T3L1 Cells. CIRCULATION. 2019. 140
Akira Sakamoto, Takehiro Ogata, Naohiko Nakanishi, Yusuke Higuchi, Yumika Tsuji, Shinya Tomita, Satoaki Matoba. SDPR/Cavin-2 in Endothelial Cells Contributes to Inflammatory Cell Adhesion in Abdominal Aortic Aneurysm. CIRCULATION. 2019. 140

学歴 (2件)：

経歴 (4件)：

所属学会 (3件)：

国際心臓研究会 , 日本循環器学会 , 日本内科学会

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樋口 雄亮