研究者
J-GLOBAL ID:202001009386086927
更新日: 2024年02月01日
齋藤 有紀
サイトウ ユウキ | Saito Yuhki
所属機関・部署:
職名:
Research Assistant Professor
研究分野 (4件):
腫瘍生物学
, 神経科学一般
, システムゲノム科学
, 分子生物学
競争的資金等の研究課題 (3件):
- 2011 - 2012 X11Lカルボキシル基末端の構造変化機構と生理的意義の解明
- 2009 - 2010 X11ファミリータンパク質の生理機能解析
- 2008 - 2008 脳特異的アダプター蛋白質X11およびX11Lの機能解析
論文 (27件):
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Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, et al. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. 2023. 123. 63-74
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Naoya Gotoh, Yuhki Saito, Saori Hata, Haruka Saito, Daiki Ojima, Chiaki Murayama, Mayo Shigeta, Takaya Abe, Daijiro Konno, Fumio Matsuzaki, et al. Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of Alcadein α-deficient mice. The Journal of biological chemistry. 2020. 295. 28. 9650-9662
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Yuhki Saito, Yuan Yuan, Ilana Zucker-Scharff, John J Fak, Saša Jereb, Yoko Tajima, Donny D Licatalosi, Robert B Darnell. Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Neuron. 2019. 101. 4. 707-720
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Rika Motodate, Haruka Saito, Yuriko Sobu, Saori Hata, Yuhki Saito, Tadashi Nakaya, Toshiharu Suzuki. X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors. Journal of neurochemistry. 2019. 148. 4. 480-498
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Yuan Yuan, Shirley Xie, Jennifer C Darnell, Andrew J Darnell, Yuhki Saito, Hemali Phatnani, Elisabeth A Murphy, Chaolin Zhang, Tom Maniatis, Robert B Darnell. Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. Genome biology. 2018. 19. 1. 117-117
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MISC (5件):
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山本 融, 後藤 直也, 齋藤 有紀, 村山 千明, 鈴木 利治. アルカデインはX11Lと協働して内在性APPのアミロイド産生的代謝を抑制する. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P1235]-[1P1235]
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Yuhki Saito, Tsuyoshi Inoue, Toshiharu Suzuki. Malfunction of HCN channels in X11(-/-); X11L(-/-) mice and Alzheimer's disease model mice. NEUROSCIENCE RESEARCH. 2011. 71. E187-E187
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Tohru Yamamoto, Naoya Gotoh, Yuhki Saito, Saori Hata, Fumio Matsuzaki, Toshiharu Suzuki. Amyloidogenic processing of APP is enhanced in Alcadein alpha-deficient mice. NEUROSCIENCE RESEARCH. 2011. 71. E85-E85
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塩野 真希, 穐山 麻由, 山本 融, 斉藤 有紀, 鈴木 利治. APP代謝と細胞内局在に果たすX11Lの機能ドメインの解析. 日本生化学会大会プログラム・講演要旨集. 2009. 82回. 4P-553
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Yuhki Saito, Yoshitake Sano, Tadashi Nakaya, Shigeyoshi Itohara, Toshiharu Suzuki. The roles of X11 and X11L in APP metabolism. NEUROSCIENCE RESEARCH. 2007. 58. S117-S117
講演・口頭発表等 (5件):
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Cell-type specific functional protein-RNA interaction in the brain
(Public seminar at Rockefeller University 2020)
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A RNA-binding protein plays differential biological roles in different neuron
(第92回日本生化学会 2019)
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Decoding cell-specific functional protein:RNA interactions in the mammalian brain
(Special Seminar Speaker in Center for NeuroGenetics and Department of Molecular Genetics & Microbiology at University of Florida 2018)
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Neuronal activity and Alzheimer's disease.
(第132回日本薬学会 2012)
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The function of X11-like protein on APP metabolism in brain
(第130回日本薬学会 2010)
学歴 (3件):
- 2006 - 2009 北海道大学 大学院生命科学院
- 2004 - 2006 北海道大学 大学院薬学研究科
- 2000 - 2004 北海道大学 薬学部
経歴 (6件):
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