Shinji Kobuchi, Mayuka Arimoto, Yukako Ito. Translational pharmacokinetic-toxicodynamic model of myelosuppression for dose optimization in combination chemotherapy of capecitabine and oxaliplatin from rats to humans. The Journal of pharmacology and experimental therapeutics. 2024
Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic-toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin-induced Peripheral Neuropathy. Anticancer research. 2024. 44. 2. 575-584
Shinji Kobuchi, Atsuko Morita, Shizuka Jonan, Kikuko Amagase, Yukako Ito. Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule. Cancer chemotherapy and pharmacology. 2023
Yukako Ito, Shinji Kobuchi, Amiri Kawakita, Kazuki Tosaka, Yume Matsunaga, Shoma Yoshioka, Shizuka Jonan, Kikuko Amagase, Katsunori Hashimoto, Mitsuro Kanda, et al. Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer. Cancers. 2023
Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda. Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation. Xenobiotica; the fate of foreign compounds in biological systems. 2023. 1-8