伊藤涼

Ito Ryo

所属機関・部署：

研究分野 (5件)：細胞生物学 , 神経科学一般 , 医療薬学 , 薬理学 , 薬系衛生、生物化学

研究キーワード (8件)： Neuro-Vascular Biology , Human Organ-on-a-chip , Microphysiological System , Modeling & Simulation , Pharmacokinetics , Transporter , Glia , Blood-Brain Barrier

論文 (7件)：

Ryo Ito, Hanae Morio, Tomoyo Baba, Yasuyuki Sakaguchi, Naomi Wakayama, Ryuto Isogai, Yoshiyuki Yamaura, Takafumi Komori, Tomomi Furihata. In Vitro-In Vivo Correlation of Blood-Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans. Pharmaceutical research. 2022. 39. 7. 1575-1586
Keita Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai, Ryo Ito, Yoshiyuki Yamaura, Saki Izumi, Takafumi Komori, Shingo Ito, Sumio Ohtsuki, et al. Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules. Molecular pharmaceutics. 2022. 19. 8. 2754-2764
Keita Kitamura, Kenta Umehara, Ryo Ito, Yoshiyuki Yamaura, Takafumi Komori, Hanae Morio, Hidetaka Akita, Tomomi Furihata. Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines. Biological and Pharmaceutical Bulletin. 2021. 44. 7. 984-991
Ryo Ito, Kenta Umehara, Shota Suzuki, Keita Kitamura, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Haruo Imawaka, Saki Izumi, Naomi Wakayama, Takafumi Komori, et al. A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies. Molecular pharmaceutics. 2019. 16. 11. 4461-4471
Kitamura K, Ito R, Umehara K, Morio H, Saito K, Suzuki S, Hashimoto M, Saito Y, Anzai N, Akita H, et al. Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies. Journal of pharmacological sciences. 2018. 137. 4. 350-358

MISC (3件)：

Ryo Ito, Tomomi Furihata, Atsuko Kamiichi, Yuchen Sun, Shinya Kawamatsu, Satoshi Kishida, Shota Suzuki, Kan Chiba. ESTABLISHMENT OF NEW IMMORTALIZED HUMAN ASTROCYTES FOR USE IN THE FUNCTIONAL CHARACTERIZATION OF ASTROCYTIC DRUG TRANSPORTERS. DRUG METABOLISM REVIEWS. 2015. 47. 256-257
Tomomi Furihata, Shinya Kawamatsu, Ryo Ito, Shota Suzuki, Kan Chiba. MODIFICATION OF CULTURE MEDIUM COMPOSITION AMELIORATES INTERCELLULAR BARRIER PROPERTY OF A HBMEC/CI beta-BASED BLOOD-BRAIN BARRIER MODEL THROUGH PROMOTION OF CELLULAR DIFFERENTIATION. DRUG METABOLISM REVIEWS. 2015. 47. 167-167
Tomomi Furihata, Shinya Kawamatsu, Ryo Ito, Atsuko Kamiichi, Satoshi Kishida, Kan Chiba. HBMEC/CIB, NEWLY-DEVELOPED CONDITIONALLY IMMORTALIZED HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELLS, EXPRESS VARIOUS RECEPTORS INVOLVED IN TRANSCYTOSIS AT THE BLOOD-BRAIN BARRIER. DRUG METABOLISM REVIEWS. 2014. 45. 53-53

講演・口頭発表等 (17件)：

Characterization of a human immortalized cell-based BBB triculture model and its potential application to prediction of in vivo drug BBB permeability.
(日本薬物動態学会第36回年会 2021)
「The “Beyond the Blood-Brain Barrier” -Research Quartet (B4-Quartet)」 ~「薬物の脳到達に関わる課題」を解決し、中枢神経系疾患治療薬開発の加速を目指す産学共同研究がスタートしました~
(2021)
Feasibility Study Towards Prediction of Brain Drug Concentration in Human. - IVIVC: in vitro Human Blood-Brain Barrier Model and PBPK Approach -
(日本薬物動態学会談話会第43年会 2020)
A New Human Cell-Based Blood-Brain Barrier Triple-culture Model ~Development and Characterization for Human Drug-Brain Permeability Studies~
(日本薬剤学会第35回年会 2020)
ヒト脳内動態予測を目指して ~ヒト血液脳関門モデルとBrain-PBPKモデルの融合~
(日本薬物動態学会第13回ショートコース 2019)

学歴 (4件)：

- 2022 Ph.D., Tokyo University of Pharmacy and Life Science
2014 - 2016 Chiba University (President’s Award of Outstanding Academic Excellence) Graduate School of Medical and Pharmaceutical Sciences
2010 - 2014 Chiba University Faculty of Pharmaceutical Sciences
2009 - 2010 Yokohama City University International College of Arts and Sciences

学位 (1件)：

Tokyo University of Pharmacy and Life Science

経歴 (5件)：

2024/10 - 現在 ONO Pharma UK Ltd, Senior Manager, Discovery Research Alliance
2022/04 - 2024/09 Ono Pharmaceutical Co., Ltd., Discover Research Alliance, Research Center of Neurology
2019/10 - 2022/03 Ono Pharmaceutical Co., Ltd., Research Center of Neurology
2018/07 - 2019/09 Ono Pharmaceutical Co., Ltd., Pharmacokinetic Research Laboratories, Discovery Pharmacokinetics
2016/04 - 2018/06 Ono Pharmaceutical Co., Ltd., Pharmacokinetic Research Laboratories, Non-clinical Pharmacokinetics

受賞 (10件)：

2021/11 - Best Poster Award, The 36th Annual Meeting of the Japanese Society for the Study of Xenobiotics
2018/10 - 22th MDO / 33th JSSX joint meeting Best Poster Award Finalist
2016/05 - Full Exemption from JASSO Scholarship Grant
2016/03 - President’s Award of Outstanding Academic Excellence
2016/03 - Excellent Master Thesis Presentation Award, Graduate School of Medical and Pharmaceutical Sciences

全件表示

所属学会 (8件)：

International Brain Barriers Society , エイチ・エー・ビー研究機構 , 日本神経化学会 , 創剤フォーラム , 日本薬剤学会 , 日本薬理学会 , 日本薬物動態学会 , 日本薬学会

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