研究キーワード (1件)：
Drug discovery, Drug development, Aptamers, Cancer, in vitro selection method, Peptide, Vitamin D3 metabolism, Biosensors, A-to-I RNA editing
競争的資金等の研究課題 (10件)：
2023 - 2026 Study on DNA aptamer-PROTAC conjugates-based selective ADAR1 degradation for cancer therapy
2023 - 2024 In cellular study of newly identified aptamers inhibitors of METTL3-METTL14 complex for cancer
2022 - Study of binding dynamics of the aptamer-CYP24A1 complex to optimize and develop aptamers as potent and specific CYP24A1 inhibitors for cancer treatment
2022 - Study of the N6-methyladenosine (m6A) writer complex (METTL3-METTL14) to develop aptamer-based METTL3 inhibitors for cancer therapy
Mark B. Meyer, Carlos Bernal-Mizrachi, Daniel D. Bikle, Madhu Biyani, Moray J. Campbell, Snehal N. Chaudhari, Sylvia Christakos, Sue A. Ingles, Megan M. Knuth, Seong Min Lee, et al. Highlights from the 24th workshop on vitamin D in Austin, September 2022. The Journal of Steroid Biochemistry and Molecular Biology. 2023. 228. 106247-106247
Madhu Biyani, Kaori Yasuda, Yasuhiro Isogai, Yuki Okamoto, Wei Weilin, Noriyuki Kodera, Holger Flechsig, Toshiyuki Sakaki, Miki Nakajima, Manish Biyani. Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells. ACS Applied Materials & Interfaces. 2022. 14. 16. 18064-18078
Radhika Biyani, Kirti Sharma, Kenji Kojima, Madhu Biyani, Vishnu Sharma, Tarun Kumawat, Kevin Maafu Juma, Itaru Yanagihara, Shinsuke Fujiwara, Eiichi Kodama, et al. Development of robust isothermal RNA amplification assay for lab-free testing of RNA viruses. Scientific reports. 2021. 11. 1. 15997-15997
Madhu Biyani, Radhika Biyani, Hiromi Ushijima, Masato Saito, Yuzuru Takamura, Eiichi Tamiya, Manish Biyani. Instant enumeration of total viable bacterial counts for food quality assurance using 'DEP-On-Go' sensor. Analytical Methods. 2018. 10. 14. 1585-1592
Madhu Biyani, Radhika Biyani, Tomoko Tsuchihashi, Yuzuru Takamura, Hiromi Ushijima, Eiichi Tamiya, Manish Biyani. DEP-On-Go for Simultaneous Sensing of Multiple Heavy Metals Pollutants in Environmental Samples. Sensors (Basel, Switzerland). 2016. 17. 1
がんのアプタマー治療薬開発におけるアプタマー-CYP24複合体の結合ダイナミクスのナノスケール可視化
(The 7th NanoLSI Symposium in Berlin; From Molecules to Cells and Tissue - Bridging Scales with Nanoprobe Technology)
癌におけるビタミンD3の機能性を増強するCYP24A1阻害のための新規環状二価DNAアプタマーのin vivo評価
(2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics [2023 ICCP450/JSSX])
SELCOS: Re-birth of Aptamer-driven Technology for Targeting Cancer Stem Cells
(India-Japan international cancer conference, Kanazawa University, July 24-25, 2023 2023)
2022/09 - Vitamini WORKSHOP 24th Vitamin D Workshop Young Investigator Award in the Junior Faculty category A NOVEL DNA APTAMER FOR CYP24 INHIBITION EXERTS A THERAPEUTIC EFFECT BY ENHANCING ANTI-PROLIFERATIVE FUNCTION OF VITAMIN D3 IN LUNG CANCER CELLS
2022/06 - AIST-INDIA DAILAB Honorarium for your lecture DNA aptamers: A new window opened for cancer
