文献

J-GLOBAL ID：202002212780275807   整理番号：20A1052224

結腸直腸癌におけるリンパ球反応,腫瘍分子特性および患者生存の統合分析【JST・京大機械翻訳】

An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer

著者 (46件)： Haruki Koichiro (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Kosumi Keisuke (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Li Peilong (Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, China) ,  Arima Kota (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Juha P. (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Juha P. (Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland) ,  Lau Mai Chan (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Twombly Tyler S. (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Hamada Tsuyoshi (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Glickman Jonathan N. (Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MS, USA) ,  Fujiyoshi Kenji (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Chen Yang (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Du Chunxia (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Guo Chunguang (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Sara A. (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Dias Costa Andressa (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Song Mingyang (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Song Mingyang (Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Song Mingyang (Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA) ,  Chan Andrew T. (Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Chan Andrew T. (Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA) ,  Chan Andrew T. (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Chan Andrew T. (Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Meyerhardt Jeffrey A. (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Nishihara Reiko (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Nishihara Reiko (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Nishihara Reiko (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Nishihara Reiko (Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Fuchs Charles S. (Yale Cancer Center, New Haven, CT, USA) ,  Fuchs Charles S. (Department of Medicine, Yale School of Medicine, New Haven, CT, USA) ,  Fuchs Charles S. (Smilow Cancer Hospital, New Haven, CT, USA) ,  Liu Li (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Liu Li (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Liu Li (Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China) ,  Zhang Xuehong (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Wu Kana (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Wu Kana (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Wu Kana (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Giannakis Marios (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Giannakis Marios (Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Giannakis Marios (Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Nowak Jonathan A. (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Ogino Shuji (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Ogino Shuji (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Ogino Shuji (Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Ogino Shuji (Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, MA, USA)
資料名： British Journal of Cancer  (British Journal of Cancer)
巻： 122  号： 9  ページ： 1367-1377  発行年： 2020年 
JST資料番号： C0922B  ISSN： 0007-0920  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 背景:組織学的リンパ球反応は,結腸直腸癌における独立予後マーカーと見なされている。適切な統計的パワーの欠如,選択バイアスの調整及び大部分の以前の研究における包括的腫瘍分子データを考慮して,2つの前向きコホート研究の統合的データベースを利用することにより,結腸直腸癌におけるリンパ球反応の予後関連の強さを調べた。【方法】:1465の結腸直腸癌症例におけるクローンのような反応,腫瘍内腫瘍周囲反応,および腫瘍浸潤リンパ球を調べた。全部で4420の結腸直腸癌症例の共変量データを用いて,逆確率加重Cox比例ハザード回帰モデルを用いて,ステージ,MSI状態,LINE-1メチル化,PTGS2およびCTNNB1発現,KRAS,BRAFおよびPIK3CA突然変異および腫瘍新生抗原負荷を含む選択バイアス(組織アベイラビリティによる)を制御した。【結果】各リンパ球反応成分のより高いレベルは,より良い結腸直腸癌特異的生存と関連していた(P_傾向<0.002)。陰性/低腫瘍内腫瘍周囲反応を有する症例と比較して,多変数調整HRsは,中間反応を有する症例において0.55(95%CI,0.42~0.71),高反応を有する症例において0.20(95%CI,0.12~0.35)であった。これらの関係はMSI状態または新生抗原負荷(P_相互作用>0.2)の地層において一貫していた。結論:4つのリンパ球反応成分は,結腸直腸癌における予後バイオマーカーである。Copyright The Author(s), under exclusive licence to Cancer Research UK 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  データベース ,  メチル化 ,  *腫瘍 ,  突然変異 ,  *リンパ球 ,  アベイラビリティ ,  地層 ,  クローン ,  予後 ,  回帰モデル ,  バイオマーカー ,  前向きコホート研究
準シソーラス用語： K-Ras ,  *結腸直腸癌 , 【Automatic Indexing@JST】

分類 (1件)： 消化器の腫よう  (GH04000D)

タイトルに関連する用語 (7件)： 結腸直腸癌 ,  リンパ球 ,  腫瘍 ,  分子特性 ,  患者生存 ,  統合 ,  分析