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J-GLOBAL ID：202002217479496135   整理番号：20A0383614

テロメア長と肺機能に対する多環芳香族炭化水素とフタル酸塩曝露の共同効果【JST・京大機械翻訳】

Joint effect of polycyclic aromatic hydrocarbons and phthalates exposure on telomere length and lung function

著者 (17件)： Hou Jian (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Hou Jian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Yin Wenjun (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Yin Wenjun (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Li Pei (State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China) ,  Hu Chen (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Hu Chen (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Xu Tian (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Xu Tian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Cheng Juan (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Cheng Juan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Li Tian (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Li Tian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Wang Lin (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...) ,  Yu Zhiqiang (State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China) ,  Yuan Jing (Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Yuan Jing (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030...)
資料名： Journal of Hazardous Materials  (Journal of Hazardous Materials)
巻： 386  ページ： Null  発行年： 2020年 
JST資料番号： B0362A  ISSN： 0304-3894  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 多環芳香族炭化水素とフタル酸エステルへの曝露は肺機能低下と関連し,人体における酸化ストレスと炎症性イベントを伴う相対テロメア長(RTL)を変化させる。しかしながら,限られたデータは,肺機能とRTLに対するPAHsとフタル酸エステルの共曝露の影響について利用可能である。著者らは,中国,武漢市における2014年の冬と2015年の夏の間の反復測定によるパイロット研究を実施した。参加者は,各季節において3日間連続して,肺機能,RTL,尿のモノヒドロキシ化PAHs(OH-PAHs)およびフタル酸塩代謝産物の測定に参加した。線形混合効果(LME)モデルおよびBayesカーネル機械回帰(BKMR)を用いて,OH-PAHsまたはフタル酸塩代謝産物と肺機能またはRTLとの関係を分析した。LMEモデルは,3日間の平均ヒドロキシフェナントレン(2+3-,4-OHHPe)または1-ヒドロキシピレンとFEV1,3日平均2+3-OHHPeとの負の相関を示した。BKMRモデルは,8つのOH-PAHsとFEV1,FVCまたはRTLとの負の関係を明らかにした。9つのフタル酸塩代謝産物は,FEV1,FVCまたはRTLに及ぼす8つのOH-PAHsの全体的影響を打ち消す可能性がある。これらの知見は,尿中フタル酸塩代謝産物がFEV1またはFVCに対する尿中OH-PAHsの負の会合に対抗する可能性があることを示し,これは生物学的老化に関するより短いRTLと部分的に関連している可能性がある。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 炎症 ,  代謝産物 ,  パイロット試験 ,  線形性 ,  *芳香族縮合炭化水素 ,  ヒドロキシ化 ,  酸化ストレス ,  芳香族カルボン酸 ,  ジカルボン酸
準シソーラス用語： フタル酸エステル ,  *肺機能 ,  *テロメア長 , 【Automatic Indexing@JST】

著者キーワード (5件)： 多環芳香族炭化水素 ,  フタル酸エステル ,  相対テロメア長 ,  肺機能 ,  Bayesカーネル機械回帰

分類 (1件)： その他の汚染原因物質  (SB05040W)

物質索引 (2件)： 1-ヒドロキシピレン ,  フタル酸

タイトルに関連する用語 (7件)： テロメア長 ,  肺機能 ,  多環芳香族炭化水素 ,  フタル酸 ,  塩 ,  曝露 ,  共同