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J-GLOBAL ID：202002217645478018   整理番号：20A1267733

CpG生成変異は多くのヒトウイルスにおいて高価である【JST・京大機械翻訳】

CpG-creating mutations are costly in many human viruses

著者 (65件)： Caudill Victoria R. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Caudill Victoria R. (Department of Biology, University of Oregon, Eugene, OR, USA) ,  Qin Sarina (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Qin Sarina (Quantitative Systems Biology, Univeristy of California, Merced, CA, USA) ,  Winstead Ryan (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Kaur Jasmeen (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Tisthammer Kaho (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Pineda E. Geo (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Solis Caroline (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Cobey Sarah (Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA) ,  Bedford Trevor (Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Carja Oana (Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, USA) ,  Eggo Rosalind M. (Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK) ,  Koelle Katia (Department of Biology, Emory University, Atlanta, GA, USA) ,  Lythgoe Katrina (Big Data Institute, University of Oxford, Oxford, UK) ,  Regoes Roland (Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland) ,  Roy Scott (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Allen Nicole (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Aviles Milo (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Baker Brittany A. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Bauer William (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Bermudez Shannel (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Carlson Corey (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Castellanos Edgar (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Catalan Francisca L. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Catalan Francisca L. (Department of Neurological Surgery, University of California, San Francisco, CA, USA) ,  Chemel Angeline Katia (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Elliot Jacob (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Evans Dwayne (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Evans Dwayne (Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA) ,  Fiutek Natalie (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Fryer Emily (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Fryer Emily (Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA) ,  Goodfellow Samuel Melvin (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Goodfellow Samuel Melvin (Health Sciences Center, University of New Mexico, Albuquerque, NM, USA) ,  Hecht Mordecai (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Hopp Kellen (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Hopson E. Deshawn Jr. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Jaberi Amirhossein (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Kinney Christen (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Lao Derek (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Le Adrienne (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Lo Jacky (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Lopez Alejandro G. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Lopez Andrea (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Lorenzo Fernando G. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Luu Gordon T. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Mahoney Andrew R. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Melton Rebecca L. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Melton Rebecca L. (UCSD Biomed Sciences PhD Program, University of California, San Diego, CA, USA) ,  Nascimento Gabriela Do (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Pradhananga Anjani (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Rodrigues Nicole S. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Rodrigues Nicole S. (Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group, University of California, Davis, CA, USA) ,  Shieh Annie (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Sims Jasmine (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Sims Jasmine (UCSF Tetrad Graduate Program, University of California, San Francisco, CA, USA) ,  Singh Rima (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Sulaeman Hasan (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Thu Ricky (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Tran Krystal (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Tran Livia (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Winters Elizabeth J. (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Wong Albert (Department of Biology, San Francisco State University, San Francisco, CA, USA) ,  Pennings Pleuni S. (Department of Biology, San Francisco State University, San Francisco, CA, USA)
資料名： Evolutionary Ecology  (Evolutionary Ecology)
巻： 34  号： 3  ページ： 339-359  発行年： 2020年 
JST資料番号： W1719A  ISSN： 0269-7653  CODEN： EVECEJ  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 突然変異はウイルスゲノムを通して起こり,有益,中性または有害である可能性がある。Gに次いでCを産生し,CpG部位を産生する変異に関心を持っている。CpG部位は真核生物およびウイルスゲノムにおいてまれである。真核生物については,メチル化された時に突然変異する傾向があるため,CpG部位は稀であると考えられている。ウイルスにおいて,CpG部位がまれである理由はほとんど知られていない。HIVにおける以前の研究は,CpG生成転移突然変異が類似の非CpG生成突然変異よりもコストが高いことを示唆した。これが他のウイルスにおけるケースであるかどうかを決定するために,著者らは,Genbank,HIVDatabナーゼ,およびVirus Pathogen資源から得られた既存のデータを用いて,種々の株,サブタイプ,およびウイルスの遺伝子にわたるCpG生成および非CpG生成突然変異の対立遺伝子頻度を分析した。著者らの結果は,CpG部位がほとんどのウイルスに対して実際に費用がかかることを示唆する。CpG部位のコストを理解することにより,ウイルスの進化と適応へのさらなる洞察を得ることができる。Copyright The Author(s) 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： メチル化 ,  遺伝子 ,  突然変異 ,  *ヒト ,  真核生物 ,  遺伝子頻度 ,  HIV【ウイルス】
準シソーラス用語： ウイルスゲノム ,  *CpG , 【Automatic Indexing@JST】

著者キーワード (4件)： 突然変異 ,  ウイルス ,  適合コスト ,  CpGサイト

分類 (2件)： 進化論一般  (EC03010Q) ,  植物生態学  (EE02000E)

タイトルに関連する用語 (4件)： CpG ,  変異 ,  ヒト ,  ウイルス