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J-GLOBAL ID：202002227143105449   整理番号：20A2254132

半数体造血幹細胞移植後の異なるサイトメガロウイルス疾患の比較【JST・京大機械翻訳】

Comparison of different cytomegalovirus diseases following haploidentical hematopoietic stem cell transplantation

著者 (66件)： Meng Xing-Ye (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Meng Xing-Ye (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Meng Xing-Ye (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Meng Xing-Ye (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Fu Hai-Xia (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Fu Hai-Xia (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Fu Hai-Xia (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Fu Hai-Xia (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Zhu Xiao-Lu (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Zhu Xiao-Lu (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Zhu Xiao-Lu (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Zhu Xiao-Lu (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Wang Jing-Zhi (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Wang Jing-Zhi (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Wang Jing-Zhi (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Wang Jing-Zhi (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Liu Xiao (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Liu Xiao (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Liu Xiao (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Liu Xiao (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Yan Chen-Hua (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Yan Chen-Hua (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Yan Chen-Hua (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Yan Chen-Hua (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Zhang Yuan-Yuan (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Zhang Yuan-Yuan (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Zhang Yuan-Yuan (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Zhang Yuan-Yuan (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Mo Xiao-Dong (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Mo Xiao-Dong (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Mo Xiao-Dong (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Mo Xiao-Dong (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Wang Yu (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Wang Yu (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Wang Yu (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Wang Yu (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Han Wei (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Han Wei (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Han Wei (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Han Wei (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Chen Yu-Hong (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Chen Yu-Hong (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Chen Yu-Hong (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Chen Yu-Hong (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Chen Ding-Bao (Department of Pathology, Peking University People’s Hospital, Beijing, China) ,  Liu Hui-Xin (Department of Clinical Epidemiology and Biostatistics, Peking University People’s Hospital, Beijing, China) ,  Chang Ying-Jun (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Chang Ying-Jun (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Chang Ying-Jun (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Chang Ying-Jun (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Xu Lan-Ping (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Xu Lan-Ping (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Xu Lan-Ping (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Xu Lan-Ping (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Liu Kai-Yan (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Liu Kai-Yan (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Liu Kai-Yan (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Liu Kai-Yan (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Huang Xiao-Jun (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Huang Xiao-Jun (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Huang Xiao-Jun (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Huang Xiao-Jun (National Clinical Research Center for Hematologic Disease, Beijing, China) ,  Zhang Xiao-Hui (Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China) ,  Zhang Xiao-Hui (Collaborative Innovation Center of Hematology, Peking University, Beijing, China) ,  Zhang Xiao-Hui (Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China) ,  Zhang Xiao-Hui (National Clinical Research Center for Hematologic Disease, Beijing, China)
資料名： Annals of Hematology  (Annals of Hematology)
巻： 99  号： 11  ページ： 2659-2670  発行年： 2020年 
JST資料番号： W4037A  ISSN： 0939-5555  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： Cytomegalovirus(CMV)は,造血幹細胞移植レシピエントにおける肺炎,胃腸炎,網膜炎および脳炎を含む最終臓器疾患を引き起こす可能性がある。異なるCMV疾患の間の潜在的差異は,不明のままである。本研究は,異なるCMV疾患における臨床的特徴,危険因子および死亡率を比較することを目的とした。方法:単一施設における半数体造血幹細胞移植を受けた3862人の患者のコホートに基づいて,遡及的ネストケースコントロール研究を行った。CMV疾患は,CMV肺炎(CMVP,n=34),証明されたCMV胃腸炎(CMVG,n=34),CMV網膜炎(CMVR,n=31),可能性のあるCMV脳炎(CMVE,n=7),および播種性CMV疾患(Di-CMVD,n=7)を含む3862のハプロ-HSCTレシピエントの113(2.92%)で発生した。CMVGのほとんどの(91.2%)症例は100日以内に発症したが,CMVRのほとんどの(90.3%)症例は後期発症であった。異なるレベルで,CMV感染およびCMVウイルス負荷は,CMVP,CMVGおよびCMVRのリスク増加と関連していた。CMV疾患のない患者と比較して,移植後1年で有意に高い非再発死亡率がCMVGよりCMVPとCMVR患者で観察された。CMVP,Di-CMVDおよびCMVEの患者は,CMVGおよびCMVR患者より診断後に高い全死亡率を示した(61.7%,57.1%,40.0%対27.7%,18.6%,P=0.001)。結論として,発症時間,ウイルス動態および死亡率は,異なるCMV疾患の間で異なる。CMV疾患の死亡率は,特にCMVP,Di-CMVDおよびCMVEに対して高いままである。Copyright Springer-Verlag GmbH Germany, part of Springer Nature 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 死亡率 ,  脳炎 ,  肺炎 ,  *サイトメガロウイルス ,  半数体 ,  網膜炎 ,  母集団 ,  *造血幹細胞 ,  危険因子 ,  *造血幹細胞移植 ,  症例対照研究
準シソーラス用語： 胃腸炎 ,  ウイルス負荷 ,  移植患者 , 【Automatic Indexing@JST】

著者キーワード (4件)： CMV疾患 ,  ウイルス動態 ,  CMV感染 ,  半数体造血幹細胞移植

分類 (1件)： 感染症・寄生虫症一般  (GD01010H)

タイトルに関連する用語 (4件)： 半数体 ,  造血幹細胞移植 ,  サイトメガロウイルス ,  疾患