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J-GLOBAL ID：202002231386894669   整理番号：20A1209337

アフリカのTrypanosoma寄生虫の蛋白質翻訳後修飾の景観【JST・京大機械翻訳】

Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites

著者 (22件)： Zhang Naiwen (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Zhang Naiwen (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Jiang Ning (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Jiang Ning (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Zhang Kai (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Zhang Kai (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Zheng Lili (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Zheng Lili (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Zhang Di (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Sang Xiaoyu (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Sang Xiaoyu (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Feng Ying (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Feng Ying (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Chen Ran (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Chen Ran (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China) ,  Yang Na (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Wang Xinyi (College of Basic Sciences, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Cheng Zhongyi (Jingjie PTM Biolab (Hangzhou) Co. Ltd, Hangzhou 310018, China) ,  Suo Xun (National Animal Protozoa Laboratory & College of Veterinary Medicine, China Agricultural University, Beijing 100193, China) ,  Lun Zhaorong (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China) ,  Chen Qijun (Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China) ,  Chen Qijun (The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China)
資料名： iScience  (iScience)
巻： 23  号： 5  ページ： Null  発行年： 2020年 
JST資料番号： W5512A  ISSN： 2589-0042  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 全ての生細胞の蛋白質は,多様な生命過程に重要な無数の翻訳後修飾(PTM)を受ける。本研究では,アフリカのトリパノソーマ,Trypanosoma bruceiおよびTrypanosoma evansiの2つの代表的な種の定量的プロテオーム分析と並行して初めての包括的な複数のPTM-オミックスアトラスを記述する。約40,000の修飾部位を有する10のPTM型および2つのアフリカのトリパノソーマの各蛋白質上に微細なマップを有する150のヒストン標識を達成した。2つの生物学的に異なるトリパノソーマ種は異なるPTM-omic特徴,調節経路及びネットワークを示した。酸化還元系に関与する蛋白質の修飾は主にT.bruceiにおいてアップレギュレートされたが,運動性に関連する蛋白質はT.evansiにおいて主に修飾された。2つの寄生虫における複数のPTMのデータベースの確立は,異なるライフサイクルを有するトリパノソーマにおける生命過程を支える生物学的機構への深い洞察を提供する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： データベース ,  ネットワーク ,  ライフサイクル ,  *寄生虫 ,  *タンパク質 ,  ヒストン ,  酸化還元反応 ,  アフリカ ,  *トリパノソーマ属 ,  Trypanosoma brucei ,  プロテオミクス ,  *翻訳後修飾 ,  プロテオーム ,  生細胞 ,  Trypanosoma evansi ,  *微生物 ,  *原生動物 ,  *鞭毛虫類 ,  *動物性鞭毛虫類

著者キーワード (2件)： プロテオミクス ,  メタボロミクス

分類 (1件)： 遺伝子発現  (EC02040Q)

タイトルに関連する用語 (6件)： アフリカ ,  Trypanosoma ,  寄生虫 ,  蛋白質 ,  翻訳後修飾 ,  景観