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J-GLOBAL ID：202002232957076149   整理番号：20A1248275

Microbiota誘導I型インターフェロンは樹状細胞の基底状態を示す【JST・京大機械翻訳】

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

著者 (63件)： Schaupp Laura (Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charite-Universitaetsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany) ,  Schaupp Laura (Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10178 Berlin, Germany) ,  Schaupp Laura (Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Schaupp Laura (Institute for Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany) ,  Muth Sabine (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Muth Sabine (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Rogell Leif (Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charite-Universitaetsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany) ,  Rogell Leif (Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10178 Berlin, Germany) ,  Rogell Leif (Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Rogell Leif (Max-Planck-Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany) ,  Kofoed-Branzk Michael (Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charite-Universitaetsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany) ,  Kofoed-Branzk Michael (Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10178 Berlin, Germany) ,  Kofoed-Branzk Michael (Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Kofoed-Branzk Michael (Max-Planck-Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany) ,  Melchior Felix (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Melchior Felix (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Lienenklaus Stefan (Institute of Immunology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Lienenklaus Stefan (Institute for Laboratory Animal Science, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Ganal-Vonarburg Stephanie C. (Department for BioMedical Research (DBMR), University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland) ,  Klein Matthias (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Klein Matthias (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Guendel Fabian (Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charite-Universitaetsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany) ,  Guendel Fabian (Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10178 Berlin, Germany) ,  Guendel Fabian (Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Hain Tobias (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Hain Tobias (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Schuetze Kristian (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Schuetze Kristian (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Grundmann Ulrike (Institute for Medical Microbiology and Hygiene, University of Freiburg Medical Center, Hermann-Herder-Str. 11, 79104 Freiburg, Germany) ,  Schmitt Vanessa (Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany) ,  Dorsch Martina (Institute for Laboratory Animal Science, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Spanier Julia (Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany) ,  Larsen Pia-Katharina (Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany) ,  Schwanz Thomas (Institute of Medical Microbiology and Hygiene, University Medical Center Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany) ,  Jaeckel Sven (Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Reinhardt Christoph (Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Bopp Tobias (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Bopp Tobias (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Bopp Tobias (University Cancer Center Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Bopp Tobias (German Cancer Consortium (DKTK)) ,  Danckwardt Sven (Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Danckwardt Sven (Posttranscriptional Gene Regulation, Cancer Research and Experimental Hemostasis, University Medical Centre Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Danckwardt Sven (Institute for Clinical Chemistry and Laboratory Medicine, University Medical Centre Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Mahnke Karsten (Department of Dermatology, Ruprecht-Karls-University Heidelberg, D-69120 Heidelberg, Germany) ,  Heinz Gitta Anne (Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Mashreghi Mir-Farzin (Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Durek Pawel (Therapeutic Gene Regulation, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Kalinke Ulrich (Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany) ,  Kalinke Ulrich (Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Kretz Oliver (III. Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany) ,  Kretz Oliver (Department for Neuroanatomy, Anatomy and Cell Biology, Medical Faculty, University of Freiburg, Freiburg, Germany) ,  Huber Tobias B. (III. Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany) ,  Weiss Siegfried (Institute of Immunology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Wilhelm Christoph (Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany) ,  Macpherson Andrew J. (Department for BioMedical Research (DBMR), University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland) ,  Schild Hansjorg (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Schild Hansjorg (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Schild Hansjorg (Helmholtz Institute Translational Oncology, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany) ,  Diefenbach Andreas (Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charite-Universitaetsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany) ,  Diefenbach Andreas (Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10178 Berlin, Germany) ,  Diefenbach Andreas (Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Chariteplatz 1, 10117 Berlin, Germany) ,  Probst Hans Christian (Institute of Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany) ,  Probst Hans Christian (Research Centre for Immunotherapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 181  号： 5  ページ： 1080-1096.e19  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 環境信号は宿主生理学と適応性を形成する。Microbiota由来の合図は定常状態の間に従来の樹状細胞(cDCs)をプログラムするために必要であるため,病原体に遭遇するとき,それらは迅速に応答し,適応免疫応答を開始することができる。しかし,微生物学的ガイド下プログラムの分子的基礎はよく理解されていない。ここでは,固有の微生物相が形質細胞様DCsによるI型インターフェロン(IFN-I)の構成的産生を制御することを報告する。無胚およびIFN-I受容体(IFNAR)欠損マウスからのcDCsの転写および後成的レギュラーの全ゲノム解析を用いて,tonic IFNARシグナリングが将来の病原体戦闘のためにcDCsを感染させる特異的エピゲノムおよび代謝基底状態を指示することを見出した。しかし,そのような有益な生物学的機能はトレードオフを伴う。指示されたcDCsは,末梢耐性のロードブロックを除去するとき,無害な末梢抗原に対してT細胞応答をプライムすることができる。著者らのデータは,それらの微生物環境への脊椎動物の成功した適応によって生じる進化的トレードオフへの新しい洞察を提供する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *基底状態 ,  微生物 ,  形質細胞 ,  抗原 ,  受容体 ,  脊椎動物 ,  生物活性 ,  ミクロフローラ ,  病原体 ,  微生物学 ,  *樹状細胞
準シソーラス用語： 適応免疫 ,  定常状態 ,  全ゲノム解析 ,  T細胞応答 , 【Automatic Indexing@JST】

著者キーワード (5件)： Microbiota ,  従来の樹状細胞 ,  形質細胞様樹状細胞 ,  I型インターフェロン ,  末梢耐性

分類 (2件)： 免疫反応一般  (ED03010T) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： Microbiota ,  誘導 ,  I型インターフェロン ,  樹状細胞 ,  基底状態