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J-GLOBAL ID：202002233141471719   整理番号：20A1915209

中国のCOVID-19における肝臓損傷マーカーと死亡率の縦断的関連【JST・京大機械翻訳】

Longitudinal Association Between Markers of Liver Injury and Mortality in COVID-19 in China

著者 (62件)： Lei Fang (Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Lei Fang (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Lei Fang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Liu Ye-Mao (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Liu Ye-Mao (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhou Feng (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhou Feng (Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Qin Juan-Juan (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Qin Juan-Juan (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhang Peng (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhang Peng (Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Zhu Lihua (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Zhu Lihua (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhang Xiao-Jing (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Zhang Xiao-Jing (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Cai Jingjing (Department of Cardiology, Central South University, The Third Xiangya Hospital, Changsha, China) ,  Lin Lijin (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Lin Lijin (Basic Medical School of Wuhan University, Wuhan, China) ,  Ouyang Shan (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Ouyang Shan (Basic Medical School of Wuhan University, Wuhan, China) ,  Wang Xiaoming (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Wang Xiaoming (Basic Medical School of Wuhan University, Wuhan, China) ,  Yang Chengzhang (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Yang Chengzhang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Cheng Xu (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Cheng Xu (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Liu Weifang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Liu Weifang (Basic Medical School of Wuhan University, Wuhan, China) ,  Li Haomiao (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Li Haomiao (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Xie Jing (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Wu Bin (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Wu Bin (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Luo Huiming (Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Xiao Fei (Department of Urology Surgery, Renmin Hospital of Wuhan University, Eastern Campus, Wuhan, China) ,  Chen Jing (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Tao Liang (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Tao Liang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Cheng Gang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  She Zhi-Gang (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  She Zhi-Gang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Zhou Jianghua (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Zhou Jianghua (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Wang Haitao (Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Lin Jun (Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Luo Pengcheng (Department of Urology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China) ,  Fu Shouzhi (Department of Intensive Care Unit, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China) ,  Zhou Jihui (Wuhan Ninth Hospital, Wuhan, China) ,  Ye Ping (Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Xiao Bing (Department of Stomatology, Xiantao First People’s Hospital, Xiantao, China) ,  Mao Weiming (Department of General Surgery, Huanggang Central Hospital, Huanggang, China) ,  Liu Liming (Department of General Surgery, Ezhou Central Hospital, Ezhou, China) ,  Yan Youqin (Wuhan Seventh Hospital, Department of Hepatology, Wuhan, China) ,  Liu Ling (Eye Center, Renmin Hospital of Wuhan University, Wuhan, China) ,  Chen Guohua (Department of Neurology, Wuhan No. 1 Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, China) ,  Li Hongliang (Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Li Hongliang (Institute of Model Animal of Wuhan University, Wuhan, China) ,  Li Hongliang (Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China) ,  Li Hongliang (Basic Medical School of Wuhan University, Wuhan, China) ,  Huang Xiaodong (Department of Gastroenterology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China) ,  Zhang Bing-Hong (Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China) ,  Yuan Yufeng (Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China)
資料名： Hepatology  (Hepatology)
巻： 72  号： 2  ページ： 389-398  発行年： 2020年 
JST資料番号： T0889A  ISSN： 0270-9139  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景と目的:コロナウイルス病2019(COVID-19)は新しい感染症である。この疾患に関連する肝損傷とその臨床的意義を明らかにするために,著者らは,湖北省におけるCOVID-19肺炎の成人患者5771人を含む多施設後向きコホート研究を実施した。APPROACHおよび結果:これらの患者における肝損傷指標の分布および時間的パターンを報告し,それらの関連因子および死亡リスクを決定した。長期的肝機能試験を遡及的に分析し,危険因子および死亡と相関させた。肝臓損傷動的パターンはアラニンアミノトランスフェラーゼ(ALT),アスパラギン酸アミノトランスフェラーゼ(AST),アルカリホスファターゼ(ALP)および総ビリルビン(TBIL)で異なった。ASTは最初に上昇し,重症患者においてALTが続いた。ALPは入院中に中程度に増加し,正常範囲に大部分が残った。TBILレベルの変動は,非重度群と重症群で軽度であった。AST異常は,入院中の肝臓損傷の他の指標と比較して,最も高い死亡率リスクと関連していた。肝臓損傷指標の上昇に伴う共通因子はリンパ球数減少,好中球数増加および男性性であった。【結論】肝臓損傷指標の動的パターンと潜在的危険因子は,COVID-19関連肝臓損傷の重要な説明を提供する可能性がある。高い肝損傷指標,特にASTは死亡率リスクと強く関連するので,著者らの研究は,これらのパラメータが入院中にモニターされるべきであることを示す。Copyright 2020 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： アスパラギン酸アミノトランスフェラーゼ ,  アラニンアミノトランスフェラーゼ ,  アルカリ性ホスファターゼ ,  *死亡率 ,  肺炎 ,  成人 ,  感染症 ,  危険因子 ,  後向きコホート研究
準シソーラス用語： *肝臓損傷 ,  肝機能 ,  重症患者 ,  死亡リスク ,  リンパ球数 ,  好中球数 , 【Automatic Indexing@JST】

分類 (2件)： 消化器の疾患  (GH03000W) ,  消化器の腫よう  (GH04000D)

タイトルに関連する用語 (4件)： 中国 ,  肝臓損傷 ,  マーカー ,  死亡