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J-GLOBAL ID：202002234010751136   整理番号：20A0883083

Creドライバー系統による神経系特異的遺伝子ターゲッティングの最適化:生殖系列組換えの有病率と影響因子【JST・京大機械翻訳】

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

著者 (74件)： Luo Lin (Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada) ,  Ambrozkiewicz Mateusz C. (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Ambrozkiewicz Mateusz C. (Institute of Cell Biology and Neurobiology, Charite-Universitaetsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, and Berlin Institute of Health, Chariteplatz 1, 10117 Berlin, Germany) ,  Benseler Fritz (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Chen Cui (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Dumontier Emilie (Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada) ,  Falkner Susanne (Biozentrum of the University of Basel, Basel, Switzerland) ,  Furlanis Elisabetta (Biozentrum of the University of Basel, Basel, Switzerland) ,  Gomez Andrea M. (Biozentrum of the University of Basel, Basel, Switzerland) ,  Hoshina Naosuke (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA) ,  Huang Wei-Hsiang (Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA) ,  Huang Wei-Hsiang (Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada) ,  Hutchison Mary Anne (Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA) ,  Itoh-Maruoka Yu (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Lavery Laura A. (Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77003, USA) ,  Lavery Laura A. (Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA) ,  Li Wei (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Maruo Tomohiko (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Maruo Tomohiko (Department of Biochemistry, Tokushima University Graduate School of Medical Sciences, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan) ,  Maruo Tomohiko (Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan) ,  Motohashi Junko (Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Pai Emily Ling-Lin (Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Pai Emily Ling-Lin (Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Pelkey Kenneth A. (Section on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA) ,  Pereira Ariane (Department of Neurobiology and Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA) ,  Philips Thomas (Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Sinclair Jennifer L. (Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA) ,  Stogsdill Jeff A. (Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA) ,  Stogsdill Jeff A. (Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02139, USA) ,  Traunmueller Lisa (Biozentrum of the University of Basel, Basel, Switzerland) ,  Wang Jiexin (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  Wortel Joke (Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and University Medical Center Amsterdam, de Boelelaan 1085, 1081 HV Amsterdam, the Netherlands) ,  You Wenjia (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  You Wenjia (Departments of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  You Wenjia (Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA) ,  Abumaria Nashat (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China) ,  Abumaria Nashat (Department of Laboratory Animal Science, Shanghai Medical College, Fudan University, Shanghai 200032, China) ,  Beier Kevin T. (Department of Physiology and Biophysics, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA) ,  Brose Nils (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Burgess Harold A. (Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA) ,  Cepko Constance L. (Departments of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Cepko Constance L. (Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA) ,  Cloutier Jean-Francois (Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada) ,  Eroglu Cagla (Department of Cell Biology, Department of Neurobiology, and Duke Institute for Brain Sciences, Regeneration Next Initiative, Duke University Medical Center, Durham, NC 27710, USA) ,  Goebbels Sandra (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Kaeser Pascal S. (Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA) ,  Kay Jeremy N. (Department of Neurobiology and Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA) ,  Lu Wei (Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA) ,  Luo Liqun (Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA) ,  Mandai Kenji (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Mandai Kenji (Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan) ,  McBain Chris J. (Section on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA) ,  Nave Klaus-Armin (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Prado Marco A.M. (Robarts Research Institute, Department of Anatomy and Cell Biology, and Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Marco A.M. (Brain and Mind Institute, The University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Vania F. (Robarts Research Institute, Department of Anatomy and Cell Biology, and Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B7, Canada) ,  Prado Vania F. (Brain and Mind Institute, The University of Western Ontario, London, ON N6A 5B7, Canada) ,  Rothstein Jeffrey (Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Rubenstein John L.R. (Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Rubenstein John L.R. (Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Saher Gesine (Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Sakimura Kenji (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Sanes Joshua R. (Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA) ,  Scheiffele Peter (Biozentrum of the University of Basel, Basel, Switzerland) ,  Takai Yoshimi (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Umemori Hisashi (F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA) ,  Verhage Matthijs (Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam and University Medical Center Amsterdam, de Boelelaan 1085, 1081 HV Amsterdam, the Netherlands) ,  Yuzaki Michisuke (Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Zoghbi Huda Yahya (Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77003, USA) ,  Zoghbi Huda Yahya (Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA) ,  Kawabe Hiroshi (Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Gottingen, Germany) ,  Kawabe Hiroshi (Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Kawabe Hiroshi (Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, 2-2 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Craig Ann Marie (Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada)
資料名： Neuron  (Neuron)
巻： 106  号： 1  ページ： 37-65.e5  発行年： 2020年 
JST資料番号： T0649A  ISSN： 0896-6273  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Cre-loxPシステムは,マウス神経系における遺伝子ノックアウト,knockイン,およびレポーター発現の空間的および時間的制御のために貴重である。しかしながら,神経系特異的組換えのために設計された異なるCreドライバ系統における予想外の生殖系列再結合の確率の変化を報告する。選択的母性または父性生殖系列再結合は,標本Cre系統で示される。照合されたデータは,精子または卵母細胞におけるCre発現に関連する親の性バイアスを有する多くの場合,64の一般的に使用されているCreドライバー系統の半分以上で生殖系列組換えを明らかにする。一般的な転写制御要素を利用するCreドライバ系統間のわずかな差異は生殖系列再結合率に影響する。特異的標的遺伝子座は異なる組換えを示した;したがって,報告者は興味のある他の遺伝子座に対する信頼できる代理ではない。類似の原理は他の組換え系や他の遺伝的に標的化された生物にも適用される。著者らは,生殖系列組換えの罹患率に注意を払い,神経科学とより広い分子遺伝学コミュニティに対する将来の研究を知らせるためのガイドラインを提供する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 再結合 ,  モザイク性 ,  *神経系 ,  精子 ,  ターゲティング ,  レコンビナーゼ ,  コミュニティ ,  卵母細胞 ,  ノッキング ,  神経科学 ,  *最適化 ,  バイアス ,  *遺伝 ,  *遺伝子ターゲティング ,  転写調節 ,  *改変

著者キーワード (10件)： 部位特異的レコンビナーゼ ,  CRE-LOX ,  生殖系列組換え ,  モザイク組換え ,  条件付き遺伝子ターゲッティング ,  条件付きノックアウト ,  条件付きノッキング ,  条件付きレポーター ,  分子遺伝学 ,  親の性バイアス

分類 (1件)： 遺伝子操作  (EC02050B)

タイトルに関連する用語 (10件)： Cre ,  ドライバー ,  系統 ,  神経系 ,  遺伝子ターゲッティング ,  最適化 ,  生殖系列 ,  組換え ,  有病率 ,  影響因子