文献

J-GLOBAL ID：202002235020062629   整理番号：20A2042900

シタグリプチンはマウスにおける全身照射誘発造血障害を軽減する【JST・京大機械翻訳】

Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice

著者 (12件)： Wang Meifang (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Dong Yinping (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Wu Jing (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Li Hongyan (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Zhang Junling (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Lu Lu (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Zhang Yuanyang (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Zhou Zewei (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Fan Saijun (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Li Deguan (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Meng Aimin (Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) ,  Meng Aimin (NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Science, CAMS&PUMC); Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Dise...)
資料名： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Medicine and Cellular Longevity (Web))
巻： 2020  ページ： Null  発行年： 2020年 
JST資料番号： U7012A  ISSN： 1942-0900  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： ジペプチジルペプチダーゼIV(DPP4)の阻害剤であるシタグリプチンは2型糖尿病の調節に関与している。しかし,全身照射(TBI)誘発造血細胞損傷におけるシタグリプチン投与の役割と機序は不明である。本研究では,シタグリプチンが造血損傷に対して治療効果を有し,7.5Gy TBI誘導死からマウスを防御し,造血細胞の数およびコロニー形成能を増加させることを示した。これらの治療効果は造血細胞におけるNOX4仲介酸化ストレスの阻害に起因し,炎症の緩和も有用であった。したがって,シタグリプチンは,TBI誘発造血損傷を改善する効果的な放射線治療薬としての可能性を有する。Copyright 2020 Meifang Wang et al. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 炎症 ,  死 ,  放射線療法 ,  *全身照射 ,  *造血 ,  2型糖尿病 ,  酸化ストレス
準シソーラス用語： ジペプチジルペプチダーゼ4 ,  造血器系障害 ,  コロニー形成 ,  造血細胞 , 【Automatic Indexing@JST】

分類 (4件)： 放射線防護薬の基礎研究  (GW19010V) ,  細胞生理一般  (EF02010S) ,  生物学的機能  (EB03040U) ,  動物に対する影響  (EK02060K)

物質索引 (1件)： シタグリプチン

引用文献 (53件)：

• N. M. Gandhi, "Baicalein protects mice against radiation-induced DNA damages and genotoxicity," Molecular and Cellular Biochemistry, vol. 379, no. 1-2, pp. 277-281, 2013.
• Y. Dong, Y. Cheng, Q. Hou, J. Wu, D. Li, H. Tian, "The protective effect of new compound XH-103 on radiation-induced GI syndrome," Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 9, 2018.
• J. G. Kiang, A. O. Olabisi, "Radiation: a poly-traumatic hit leading to multi-organ injury," Cell Biosci, vol. 9, no. 1, 2019.
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• T. Reya, "Regulation of hematopoietic stem cell self-renewal," Recent Progress in Hormone Research, vol. 58, no. 1, pp. 283-295, 2003.

タイトルに関連する用語 (5件)： シタグリプチン ,  マウス ,  全身照射 ,  誘発 ,  造血障害