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J-GLOBAL ID：202002238892872414   整理番号：20A1524640

細胞分化および再プログラミング中のゲノムワイドRループ景観【JST・京大機械翻訳】

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming

著者 (45件)： Yan Pengze (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Yan Pengze (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Liu Zunpeng (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Zunpeng (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Song Moshi (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Song Moshi (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Song Moshi (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Wu Zeming (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Wu Zeming (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Xu Wei (Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China) ,  Li Kuan (Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China) ,  Ji Qianzhao (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Ji Qianzhao (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Wang Si (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Wang Si (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Wang Si (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Xiaoqian (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Xiaoqian (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Yan Kaowen (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Yan Kaowen (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Yan Kaowen (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Esteban Concepcion Rodriguez (Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA) ,  Ci Weimin (China National Center for Bioinformation, Beijing 100101, China) ,  Ci Weimin (CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China) ,  Ci Weimin (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Ci Weimin (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Belmonte Juan Carlos Izpisua (Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA) ,  Xie Wei (Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China) ,  Ren Jie (China National Center for Bioinformation, Beijing 100101, China) ,  Ren Jie (CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China) ,  Ren Jie (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Ren Jie (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Zhang Weiqi (China National Center for Bioinformation, Beijing 100101, China) ,  Zhang Weiqi (CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China) ,  Zhang Weiqi (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Zhang Weiqi (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Sun Qianwen (Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China) ,  Qu Jing (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Qu Jing (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Qu Jing (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Guang-Hui (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Guang-Hui (National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China) ,  Liu Guang-Hui (Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China) ,  Liu Guang-Hui (University of Chinese Academy of Sciences, Beijing 100049, China) ,  Liu Guang-Hui (Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China)
資料名： Cell Reports  (Cell Reports)
巻： 32  号： 1  ページ： Null  発行年： 2020年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： DNA:RNAハイブリッドは,クロマチンとゲノム構成を調節することにより,生理学的および病態の両方で重要な役割を果たす。細胞分化と細胞可塑性の間のそれらのホメオスタシスは,不明のままである。同質遺伝子ヒト幹細胞プラットフォームを用いて,多能性細胞およびそれらの系統分化誘導体におけるRループ,DNAメチル化,ヒストン修飾およびクロマチンアクセシビリティを系統的に特性化した。Rループの一部が多能性幹細胞の多能性遺伝子および分化した系統における系統制御遺伝子において共転写的に形成されることを確認した。特に,分化後に維持されたRループのサブセットは,サイレント多能性遺伝子および望ましくない系統遺伝子に対する抑制クロマチンマークと関連する。さらに,再プログラムされた多能性細胞において,細胞起源特異的Rループは,最初に存在するが,連続継代で解決される。本解析は細胞運命決定におけるRループの多面的役割を示唆し,これは細胞運命記憶と細胞可塑性の調節の付加的層として役立つかもしれない。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： DNA【核酸】 ,  RNA【核酸】 ,  遺伝子 ,  クロマチン ,  ヒト ,  *分化 ,  ホメオスタシス ,  継代培養 ,  *細胞分化 ,  多能性幹細胞
準シソーラス用語： DNAメチル化 ,  分化誘導 ,  *リプログラミング ,  細胞運命 ,  ヒストン修飾 , 【Automatic Indexing@JST】

分類 (2件)： 細胞生理一般  (EF02010S) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (4件)： 細胞分化 ,  再プログラミング ,  ゲノム ,  景観