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J-GLOBAL ID：202002239776138598   整理番号：20A1626880

初回転移性鼻咽頭癌における全身化学療法と逐次局所放射線療法:821例の後向き分析【JST・京大機械翻訳】

Systemic chemotherapy and sequential locoregional radiotherapy in initially metastatic nasopharyngeal carcinoma: Retrospective analysis with 821 cases

著者 (25件)： Huang Tianying (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Huang Tianying (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Huang Tianying (Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Su Ning (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Su Ning (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Su Ning (Department of Oncology, Guangzhou Chest Hospital, Guangzhou, China) ,  Zhang Xuanye (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Zhang Xuanye (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Ma Shuyun (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Ma Shuyun (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Zhong Guangzheng (Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China) ,  Tian Xiaopeng (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Tian Xiaopeng (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Chen Qiuyan (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Chen Qiuyan (Department of Nasopharyngeal, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Tang Linglong (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Tang Linglong (Department of Radiotherapy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Lu Lixia (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Lu Lixia (Department of Radiotherapy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Fang Yu (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Fang Yu (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Cai Jun (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Cai Jun (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Cai Qingqing (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China) ,  Cai Qingqing (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China)
資料名： Head & Neck: Journal for the Sciences & Specialties of the Head and Neck  (Head & Neck: Journal for the Sciences & Specialties of the Head and Neck)
巻： 42  号： 8  ページ： 1970-1980  発行年： 2020年 
JST資料番号： W2592A  ISSN： 1043-3074  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景:最初に転移性鼻咽頭癌(NPC)患者に対する最良の治療様式を探索するため,この後ろ向き研究を設計した。方法:2008年から2017年まで,821人の患者を登録した。治療様式と予後因子を分析した。結果:化学療法単独および放射線療法に基づく治療と比較して,鼻咽頭原発腫瘍部位に対する全身化学療法-連続局所放射線療法は,3年全生存率(OS)率(40.3%,11.7%および22.9%,P<0.001)の有意な増加と関連していた。第一選択化学療法としての白金およびフルオロウラシル(TPF)処方と組み合わせたパクリタキセルの全体的応答率は,パクリタキセル+白金(TP)処方のそれより高かった(78.2%対70.0%,P=0.038)。より良いOSは,TPF群で,二重薬剤処方(3年OS,35.7%対25.3%,P<0.001)と比較して達成された。結論:全身化学療法-連続局所放射線療法は,初期転移性NPCの選択された患者に対しOSと無増悪生存を延長できる。Copyright 2020 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 白金 ,  *放射線療法 ,  *薬物療法 ,  脂環式化合物 ,  脂肪酸 ,  芳香族カルボン酸 ,  酸素複素環化合物 ,  オレフィン化合物 ,  架橋化合物 ,  カルボン酸エステル ,  アミノアルコール ,  アミノカルボン酸 ,  第二アルコール ,  ヒドロキシ酸 ,  ヒドロキシケトン ,  ポリオール
準シソーラス用語： *鼻咽頭 ,  後向き研究 ,  *全身化学療法 ,  予後因子 ,  無増悪生存期間 ,  3年全生存率 ,  腫瘍発生部位 ,  *転移性 , 【Automatic Indexing@JST】

著者キーワード (5件)： 化学療法 ,  局所治療 ,  転移 ,  上咽頭癌 ,  放射線治療

分類 (2件)： 腫ようの放射線療法  (GE03034K) ,  耳・鼻・咽頭・喉頭の腫よう  (GQ04000E)

物質索引 (1件)： パクリタキセル

タイトルに関連する用語 (5件)： 転移性 ,  鼻咽頭癌 ,  全身化学療法 ,  放射線療法 ,  後向き分析