文献

J-GLOBAL ID：202002240113513647   整理番号：20A0716945

アジア人集団における前立腺がんのゲノムアトラスとエピゲノムアトラス

A genomic and epigenomic atlas of prostate cancer in Asian populations

著者 (68件)： LI Jing (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  XU Chuanliang (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  REN Shancheng (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZI Xiaoyuan (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  WANG Haifeng (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Chenghua (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  GAO Xiaofeng (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  HOU Jianguo (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Bo (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Qing (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YE Huamao (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHOU Tie (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  LU Xin (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  WANG Yan (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  QU Min (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHANG Wenhui (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  CHEN Rui (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  CHEN Huan (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHU Feng (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  LIAN Bijun (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHANG Yun (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  WANG Chao (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  XIAO Guangan (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Yue (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  GAO Xu (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  SUN Yinghao (Dep. of Urology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  LI Jing (Center for Translational Medicine, Second Military Medical Univ., Shanghai, CHN) ,  LI Jing (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  XU Chuanliang (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  REN Shancheng (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  WANG Yue (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  JIANG Junfeng (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  GAO Xu (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  SUN Yinghao (Shanghai Key Lab. of Cell Engineering, Shanghai, CHN) ,  LEE Hyung Joo (Dep. of Genetics, Washington Univ. School of Medicine, St Louis, MO, USA) ,  SHAH Nakul M. (Dep. of Genetics, Washington Univ. School of Medicine, St Louis, MO, USA) ,  PEHRSSON Erica C. (Dep. of Genetics, Washington Univ. School of Medicine, St Louis, MO, USA) ,  WANG Ting (Dep. of Genetics, Washington Univ. School of Medicine, St Louis, MO, USA) ,  LEE Hyung Joo (Edison Family Center for Genome Sci. and Systems Biology, Washington Univ. School of Medicine, St Louis, MO, USA) ,  SHAH Nakul M. (Edison Family Center for Genome Sci. and Systems Biology, Washington Univ. School of Medicine, St Louis, MO, USA) ,  PEHRSSON Erica C. (Edison Family Center for Genome Sci. and Systems Biology, Washington Univ. School of Medicine, St Louis, MO, USA) ,  WANG Ting (Edison Family Center for Genome Sci. and Systems Biology, Washington Univ. School of Medicine, St Louis, MO, USA) ,  ZHANG Zhiming (Novogene Co, Ltd, Beijing, CHN) ,  LI Xiaoyun (Novogene Co, Ltd, Beijing, CHN) ,  YU Yongwei (Dep. of Pathology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHU Yan (Dep. of Pathology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Chenghua (CAS Key Lab. of Tissue Microenvironment and Tumor, Shanghai Inst. of Nutrition and Health, Shanghai Inst. for Biological Sci., Univ. Chinese Acad. of Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  WANG Linhui (Dep. of Urology, Changzheng Hospital, Second Military Medical Univ., Shanghai, CHN) ,  YANG Qingsong (Dep. of Radiology, Changhai Hospital, Second Military Medical Univ., Shanghai, CHN) ,  WANG Shuo (Dep. of Urology, First Affiliated Hospital, Coll. of Medicine, Zhejiang Univ., Hangzhou, CHN) ,  WANG Zengjun (State Key Lab. of Reproductive Medicine and Dep. of Urology, the First Affiliated Hospital of Nanjing Medical Univ., Nanjing, CHN) ,  JIANG Jun (Dep. of Urology, Inst. of Surgery Res., Daping Hospital, Third Military Medical Univ., Chongqing, CHN) ,  WANG Yue (Dep. of Histology and Embryology, Second Military Medical Univ., Shanghai, CHN) ,  JIANG Junfeng (Dep. of Histology and Embryology, Second Military Medical Univ., Shanghai, CHN) ,  LIANG Chaozhao (Dep. of Urology, First Affiliated Hospital of Anhui Medical Univ., Hefei, CHN) ,  HOU Jianquan (Dep. of Urology, First Affiliated Hospital of Soochow Univ., Suzhou, CHN) ,  HAN Conghui (Dep. of Urology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital of Medical Coll. of Southeast Univ., Xuzhou, CHN) ,  CHEN Ming (Dep. of Urology, Zhongda Hospital, Southeast Univ., Nanjing, CHN) ,  JIANG Ning (Dep. of Urology, Gongli Hospital, Second Military Medical Univ., Shanghai, CHN) ,  ZHANG Dahong (Dep. of Urology, Zhejiang Provincial People’s Hospital, Hangzhou Medical Coll., Hangzhou, CHN) ,  WU Song (Dep. of Urology Inst. of Shenzhen Univ., Shenzhen Luohu People’s Hospital, Shenzhen, CHN) ,  YANG Jinjian (Dep. of Urology, First Affiliated Hospital of Zhengzhou Univ., Zhengzhou, CHN) ,  WANG Tao (Dep. of Urology, First Affiliated Hospital of Zhengzhou Univ., Zhengzhou, CHN) ,  CHEN Yongliang (Dep. of Urology, Shaoxing Central Hospital, Shaoxing, CHN) ,  CAI Jiantong (Dep. of Urology, Shishi Hospital, Shishi, CHN) ,  YANG Wenzeng (Dep. of Urology, Affiliated Hospital of Hebei Univ., Baoding, CHN) ,  XU Jun (Dep. of Urology, Huadong Hospital, Fudan Univ., Shanghai, CHN) ,  WANG Shaogang (Dep. of Urology, Tongji Hospital, Tongji Medical Coll. Huazhong Univ. Sci. and Technol., Wuhan, CHN)
資料名： Nature (London)  (Nature (London))
巻： 580  号： 7801  ページ： 93-99  発行年： 2020年04月02日 
JST資料番号： D0193B  ISSN： 0028-0836  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 前立腺がんは,男性のがんでは世界で2番目に多い。この10年間で行われた大規模な統合ゲノミクス研究によって,数千人の患者についてその遺伝的およびエピジェネティックな全体像の特性が明らかにされ,この疾患に関する理解が深まってきた。しかし,これらの研究でプロファイリングが行われた腫瘍のほとんどは,西洋人の患者から得られたものである。本研究では,中国人の原発性前立腺がん患者から得た,腫瘍組織試料とそれらに対応する健常な対照組織208対について,全ゲノム,全トランスクリプトームおよびDNAメチル化データを作製し解析した。公開されている2554の前立腺腫瘍のデータとの体系的な比較から,中国人患者のゲノム変化シグネチャーは,西洋人コホートのそれとは著しく異なることが明らかになった。具体的には,腫瘍の41%でFOXA1に変異が見られ,ZNF292とCHD1がそれぞれ18%で欠失していた。ゲノムとエピゲノムの変化は相関しており,これらの変化はがんの表現型とプログレッションを予示した。コーディング変異とノンコーディング変異だけでなく,エピ変異も前立腺がんに重要な経路へと収束が見られ,この重篤な疾患についての手掛かりが得られた。これらの発見は,疾患の総合的ゲノムマップを構築する上で,集団背景を含めることの重要性をはっきりと示している。Copyright Nature Japan KK 2020

シソーラス用語： 母集団 ,  腫瘍 ,  トランスクリプトーム ,  遺伝 ,  男性 ,  表現型 ,  *ゲノム ,  *前立腺腫瘍 ,  エピジェネティクス
準シソーラス用語： DNAメチル化 ,  中国人 ,  プロファイリング ,  ゲノミクス ,  *エピゲノム ,  *アトラス , 【Automatic Indexing@JST】

分類 (2件)： 遺伝的変異  (EC01030Y) ,  発癌機序・因子  (GE02020C)

タイトルに関連する用語 (5件)： アジア人 ,  集団 ,  前立腺がん ,  ゲノム ,  アトラス