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J-GLOBAL ID：202002240803541515   整理番号：20A2635872

新興真菌病原体Candida aurisに対する宿主免疫応答への転写的および機能的洞察【JST・京大機械翻訳】

Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris

著者 (31件)： Bruno Mariolina (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Kersten Simone (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Kersten Simone (Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Bain Judith M. (Medical Research Council Centre for Medical Mycology, University of Aberdeen, Aberdeen, UK) ,  Jaeger Martin (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Rosati Diletta (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Kruppa Michael D. (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Lowman Douglas W. (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Rice Peter J. (Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA) ,  Graves Bridget (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Ma Zuchao (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Jiao Yue Ning (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Chowdhary Anuradha (Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India) ,  Renieris George (4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece) ,  van de Veerdonk Frank L. (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  van de Veerdonk Frank L. (Center of Expertise in Mycology, Radboud University Medical Center and Canisius Wilhelmina Hospital, Nijmegen, the Netherlands) ,  Kullberg Bart-Jan (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Kullberg Bart-Jan (Center of Expertise in Mycology, Radboud University Medical Center and Canisius Wilhelmina Hospital, Nijmegen, the Netherlands) ,  Giamarellos-Bourboulis Evangelos J. (4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece) ,  Hoischen Alexander (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Hoischen Alexander (Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Gow Neil A. R. (Medical Research Council Centre for Medical Mycology, University of Aberdeen, Aberdeen, UK) ,  Gow Neil A. R. (MRC Centre for Medical Mycology, University of Exeter, Exeter, UK) ,  Brown Alistair J. P. (Medical Research Council Centre for Medical Mycology, University of Aberdeen, Aberdeen, UK) ,  Brown Alistair J. P. (MRC Centre for Medical Mycology, University of Exeter, Exeter, UK) ,  Meis Jacques F. (Center of Expertise in Mycology, Radboud University Medical Center and Canisius Wilhelmina Hospital, Nijmegen, the Netherlands) ,  Meis Jacques F. (Bioprocess Engineering and Biotechnology Graduate Program, Federal University of Parana, Curitiba, Brazil) ,  Meis Jacques F. (Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands) ,  Williams David L. (Departments of Surgery, Biomedical Sciences and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA) ,  Netea Mihai G. (Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Netea Mihai G. (Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany)
資料名： Nature Microbiology  (Nature Microbiology)
巻： 5  号： 12  ページ： 1516-1531  発行年： 2020年 
JST資料番号： W4779A  ISSN： 2058-5276  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： Candida aurisは最も重要な新興真菌病原体であるが,その免疫認識と制御への機構的洞察は不足している。ここでは,C.aurisに対する自然防御機構を明らかにするため,転写および機能的免疫細胞プロファイリングを統合した。C.aurisは,Candida albicansと比較してより強いサイトカイン応答であるヒト単核細胞において特異的トランスクリプトームを誘導するが,低いマクロファージ溶解能を示す。C.auris誘導自然免疫活性化はC型レクチン受容体の認識を介して仲介され,主に構造的にユニークなC.aurisマンノ蛋白質により誘導される。播種性カンジダ症のin vivo実験モデルにおいて,C.aurisはC.albicansよりも毒性が低かった。まとめると,これらの結果は,C.aurisが先天性宿主防御の強力な誘導因子であり,アジュバント免疫療法のための可能な標的を同定することを示す。転写および機能的免疫細胞プロファイリングは,Candida aurisが先天性宿主防御の強い誘導因子であり,アジュバント免疫療法のための可能な標的を同定することを明らかにする。Copyright The Author(s), under exclusive licence to Springer Nature Limited 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 溶解 ,  ヒト ,  *真菌類 ,  鵞口瘡カンジダ ,  カンジダ症 ,  *病原体 ,  マクロファージ ,  単球 ,  サイトカイン ,  トランスクリプトーム
準シソーラス用語： 免疫細胞 ,  C型レクチン受容体 ,  *宿主免疫応答 ,  免疫活性化 ,  プロファイリング , 【Automatic Indexing@JST】

分類 (1件)： 感染症・寄生虫症一般  (GD01010H)

タイトルに関連する用語 (6件)： 真菌 ,  病原体 ,  Candida ,  宿主免疫応答 ,  転写 ,  洞察