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J-GLOBAL ID：202002240946840824   整理番号：20A1028265

MECP2は慢性疼痛の世代間伝達を仲介する【JST・京大機械翻訳】

MeCP2 mediates transgenerational transmission of chronic pain

著者 (20件)： Tao Wenjuan (Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, PR China) ,  Tao Wenjuan (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Chen Changmao (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Wang Yuping (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Zhou Wenjie (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Jin Yan (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Mao Yu (Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, PR China) ,  Mao Yu (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Mao Yu (Department of Anesthesiology and Pain Management, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China) ,  Wang Haitao (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Wang Likui (Department of Anesthesiology and Pain Management, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China) ,  Xie Wen (Department of Psychology, Anhui Mental Health Center, Hefei 230026, PR China) ,  Zhang Xulai (Department of Psychology, Anhui Mental Health Center, Hefei 230026, PR China) ,  Li Jie (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Li Juan (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China) ,  Li Xiangyao (Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, PR China) ,  Tang Zhen-Quan (Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR 97239, USA) ,  Zhou Chenghua (Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA) ,  Pan Zhizhong Z. (Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA) ,  Zhang Zhi (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Brain Function and Disease of Chinese Academy of Science, Department of Biophysics and Neurobiology, University of Science and Technology of China, Hefei 230027, PR China)
資料名： Progress in Neurobiology  (Progress in Neurobiology)
巻： 189  ページ： Null  発行年： 2020年 
JST資料番号： A1140A  ISSN： 0301-0082  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 疼痛症状は世代を通して伝達されるが,これらの結果の基礎となる機序はほとんど理解されていない。ここでは,疼痛の経世代的伝達における一次体性感覚皮質(S1)グルタミン酸ニューロンDNAメチル-CpG結合蛋白質2(MeCP2)の必須役割を同定した。雌マウス慢性疼痛モデルにおいて,子孫は有意な疼痛感作を示した。これらのマウスでは,MeCP2発現はS1グルタミン酸(Glu~S1)ニューロンで増加し,ニューロン活性の増加と相関した。疼痛を有する母体マウスにおけるGlu~S1ニューロンMeCP2のダウンレギュレーションは,子孫疼痛感作を消失させたが,ナイーブな母親マウスにおけるMeCP2の過剰発現は,子孫における疼痛感作を誘導した。注目すべきことに,単一細胞配列決定とクロマチン免疫沈降分析は,広範囲の遺伝子の発現が子孫と母性Glu~S1ニューロンで変化し,その一部はMeCP2により調節されることを示した。これらの結果は,Glu-S1ニューロンの不適合に対する作用を介して,疼痛の経世代的伝達における重要な調節因子としてMeCP2の推定上の重要性をまとめて示す。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ニューロン ,  DNA【核酸】 ,  遺伝子 ,  感作 ,  *疼痛 ,  ダウンレギュレーション
準シソーラス用語： クロマチン免疫沈降反応 ,  *慢性疼痛 ,  結合蛋白質 ,  調節因子 ,  単一細胞 ,  CpG ,  メチル化CpG結合蛋白質2 ,  過剰発現 , 【Automatic Indexing@JST】

著者キーワード (5件)： 慢性疼痛 ,  MECP2 ,  一次体性感覚野 ,  グルタミン作動性ニューロン ,  世代間伝送

分類 (1件)： 神経の基礎医学  (GN01020W)

タイトルに関連する用語 (4件)： MeCP2 ,  慢性疼痛 ,  世代 ,  仲介