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J-GLOBAL ID：202002242215912511   整理番号：20A2528367

妊娠および胎盤酸化ストレスおよび炎症性mRNA発現中のアルミニウムおよびマグネシウム状態:中国Ma’anshan出生コホート研究【JST・京大機械翻訳】

Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma’anshan birth cohort study

著者 (52件)： Wang Jian-Qing (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Wang Jian-Qing (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Wang Jian-Qing (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Wang Jian-Qing (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Wang Jian-Qing (The Fourth Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China) ,  Hu Ya-Bin (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Hu Ya-Bin (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Hu Ya-Bin (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Hu Ya-Bin (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Liang Chun-Mei (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Liang Chun-Mei (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Liang Chun-Mei (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Liang Chun-Mei (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Xia Xun (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Xia Xun (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Xia Xun (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Xia Xun (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Xia Xun (Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China) ,  Li Zhi-Juan (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Li Zhi-Juan (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Li Zhi-Juan (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Li Zhi-Juan (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Gao Hui (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Gao Hui (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Gao Hui (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Gao Hui (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Gao Hui (Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China) ,  Sheng Jie (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Sheng Jie (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Sheng Jie (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Sheng Jie (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Huang Kun (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Huang Kun (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Huang Kun (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Huang Kun (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Wang Su-Fang (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Wang Su-Fang (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Wang Su-Fang (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Wang Su-Fang (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Li Yan (The Fourth Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China) ,  Zhu Peng (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Zhu Peng (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Zhu Peng (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Zhu Peng (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Hao Jia-Hu (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Hao Jia-Hu (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Hao Jia-Hu (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Hao Jia-Hu (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China) ,  Tao Fang-Biao (Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China) ,  Tao Fang-Biao (MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China) ,  Tao Fang-Biao (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China) ,  Tao Fang-Biao (Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China)
資料名： Environmental Geochemistry and Health  (Environmental Geochemistry and Health)
巻： 42  号： 11  ページ： 3887-3898  発行年： 2020年 
JST資料番号： D0706A  ISSN： 0269-4042  CODEN： EGHEE3  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 本研究の目的は,胎盤酸化ストレスおよび炎症性mRNA発現に対する出生前AlおよびMgの影響を調べることであった。中国のMa’anshan出生コホートからの合計2519人の妊婦が本研究に参加した。AlとMgレベルを誘導結合プラズマ質量分析(ICP-MS)で測定した。胎盤ストレスと炎症性mRNA発現をRT-PCRにより評価した。妊娠第1期および第2期および臍帯血におけるAlレベル中央値は,対応する中央値Mgレベルより高かった。低いAlとMgレベルの予測因子は,混合線形モデルによるHan民族性と高教育を含んだ。多重線形回帰分析は,AlとAl/Mgレベルが妊娠第2期において炎症性mRNA発現と胎盤酸化ストレスとの正の関連を持つことを明らかにした。IL-1β発現を除いて,臍帯血におけるAlとAl/Mgレベルと炎症性mRNA発現および胎盤酸化ストレスの間に負の相関が存在した。結論として,出生前AlおよびMg状態は,胎盤酸化ストレスおよび炎症性mRNA発現と関係した。関連する機構を確認するために,より多くの前臨床研究が必要である。Copyright Springer Nature B.V. 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 教育 ,  *アルミニウム ,  *マグネシウム ,  *炎症 ,  *胎盤 ,  ICP-MS分析 ,  妊娠初期 ,  臍帯血 ,  インターロイキン1 ,  *酸化ストレス ,  RT-PCR法 ,  妊婦
準シソーラス用語： 予測因子 ,  *mRNA発現 ,  多重線形回帰 , 【Automatic Indexing@JST】

著者キーワード (4件)： 酸化ストレス ,  炎症mRNA発現 ,  ICP-MS ,  RT-PCR

分類 (2件)： 重金属とその化合物一般  (SB05021R) ,  土壌汚染  (FB04100T)

タイトルに関連する用語 (11件)： 妊娠 ,  胎盤 ,  酸化ストレス ,  炎症 ,  mRNA発現 ,  アルミニウム ,  マグネシウム ,  中国 ,  MA ,  出生コホート ,  研究