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J-GLOBAL ID：202002242337879524   整理番号：20A2727068

メコン亜地域における抗マラリア薬に対する耐性の分子疫学:観察研究【JST・京大機械翻訳】

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

著者 (67件)： Imwong Mallika (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Imwong Mallika (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Dhorda Mehul (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Dhorda Mehul (Worldwide Antimalarial Resistance Network, Bangkok, Thailand) ,  Myo Tun Kyaw (Department of Preventive and Social Medicine, Defence Services Medical Academy, Yangon, Myanmar) ,  Thu Aung Myint (Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand) ,  Phyo Aung Pyae (Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand) ,  Phyo Aung Pyae (Myanmar Oxford Clinical Research Unit, Yangon, Myanmar) ,  Proux Stephane (Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand) ,  Suwannasin Kanokon (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Kunasol Chanon (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Srisutham Suttipat (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Duanguppama Jureeporn (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Vongpromek Ranitha (Worldwide Antimalarial Resistance Network, Bangkok, Thailand) ,  Promnarate Cholrawee (Worldwide Antimalarial Resistance Network, Bangkok, Thailand) ,  Saejeng Aungkana (Bureau of Vector-borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand) ,  Khantikul Nardlada (Office of Disease Prevention and Control Region 1, Chiang Mai, Thailand) ,  Sugaram Rungniran (Bureau of Vector-borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand) ,  Thanapongpichat Supinya (Faculty of Medical Technology, Prince of Songkla University, Songkhla, Thailand) ,  Sawangjaroen Nongyao (Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand) ,  Sutawong Kreepol (Buntharik Hospital, Amphoe Buntharik, Ubon Ratchathani, Thailand) ,  Han Kay Thwe (Department of Medical Research, Ministry of Health and Sports, Yangon, Myanmar) ,  Htut Ye (Department of Medical Research, Ministry of Health and Sports, Yangon, Myanmar) ,  Linn Khin (Department of Medical Research, Ministry of Health and Sports, Yangon, Myanmar) ,  Win Aye Aye (Department of Tropical and Infectious Diseases, University of Medicine 1, Yangon, Myanmar) ,  Hlaing Tin M (Defence Services Medical Research Centre, Naypyitaw, Myanmar) ,  van der Pluijm Rob W (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  van der Pluijm Rob W (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mayxay Mayfong (Institute of Research and Education Development, University of Health Sciences, Ministry of Health, Vientiane, Laos) ,  Mayxay Mayfong (Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos) ,  Pongvongsa Tiengkham (Savannakhet Provincial Health Department, Phonsavangnuea village, Kaysone-Phomvihan district, Savannakhet, Laos) ,  Phommasone Koukeo (Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos) ,  Tripura Rupam (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Tripura Rupam (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Peto Thomas J (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Peto Thomas J (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  von Seidlein Lorenz (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  von Seidlein Lorenz (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Nguon Chea (National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia) ,  Lek Dysoley (National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia) ,  Chan Xin Hui S (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Chan Xin Hui S (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Rekol Huy (National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia) ,  Leang Rithea (National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia) ,  Huch Cheah (National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia) ,  Kwiatkowski Dominic P (Wellcome Sanger Institute, Hinxton, UK) ,  Kwiatkowski Dominic P (Medical Research Council Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK) ,  Miotto Olivo (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Miotto Olivo (Wellcome Sanger Institute, Hinxton, UK) ,  Miotto Olivo (Medical Research Council Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK) ,  Ashley Elizabeth A (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Ashley Elizabeth A (Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos) ,  Kyaw Myat Phone (Department of Medical Research, Myanmar Health Network Organization, Yangon, Myanmar) ,  Pukrittayakamee Sasithon (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Pukrittayakamee Sasithon (Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Pukrittayakamee Sasithon (The Royal Society of Thailand, Dusit, Bangkok, Thailand) ,  Day Nicholas P J (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Day Nicholas P J (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dondorp Arjen M (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  Dondorp Arjen M (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Smithuis Frank M (Myanmar Oxford Clinical Research Unit, Yangon, Myanmar) ,  Smithuis Frank M (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Smithuis Frank M (Medical Action Myanmar, Yangon, Myanmar) ,  Nosten Francois H (Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand) ,  Nosten Francois H (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  White Nicholas J (Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) ,  White Nicholas J (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK)
資料名： Lancet Infectious Diseases  (Lancet Infectious Diseases)
巻： 20  号： 12  ページ： 1470-1480  発行年： 2020年 
JST資料番号： W3107A  ISSN： 1473-3099  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： より大きなメコンサブ領域はPlasmodium falciparumマラリアにおける抗マラリア薬耐性の再発源である。本研究は,2007年から2018年の間のこの全地域にわたる耐性の程度と広がりを特徴づけた。Myanmar,タイ,Laos,およびCambodiaからのPfalciparum分離株を,2007年1月1日,2007年12月31日に行われた臨床試験および疫学的研究から得た,そして,抗マラリア薬耐性の分子マーカー(pfkelch,pfcrt,pfplasmain2,およびpfmdr1)について遺伝子型を決定した。標的遺伝子周辺の隣接配列のマイクロサテライトと一塩基多型タイピングを用いて遺伝的関連性を評価した。10632の分離株は遺伝子型を決定した。アルテミシニン耐性(PfPailin)を与える単一長pfkelch Cys580Tyrハプロタイプ(-50kbから+31 5kb)は,現在,東大メコンサブ領域にわたって優勢である。Lys76Thrクロロキン耐性遺伝子座のpfcrt下流におけるpfplasplasin2遺伝子増幅と変異に関連するPiperakin耐性も開発した。タイ-ミャンマー境界において,異なるpfkelch Cys580Tyr系統は,それを除去する前に高頻度に上昇した。Myanmarでは,Cys580Tyr対立遺伝子は,低対立遺伝子頻度で広く分布している。一方,単一アルテミシニン耐性pfkelch Phe446Ileハプロタイプはミャンマーに広がった。Kayin州におけるジヒドロアルテミシニン-ピペラキンの強い使用にもかかわらず,Myanmar東部は,治療と大量薬物投与の両方で,ピペラキン耐性マーカーの選択は観察されなかった。メフロキンに対する耐性のマーカーであるpfmdr1増幅は,全領域にわたって低い罹患率のままである。Pfalciparumにおけるアルテミシニン耐性は,現在,より大きなメコンサブ領域にわたって一般的である。東部のMekong亜地域では,多剤耐性Palciparum系統(PfPailin)が優勢である。Myanmarでは,長いpfkelch Phe446Ileハプロタイプは広く広がったが,東部のMekong亜領域とは対照的に,遺伝子タイピング既知マーカーからのアルテミシニン併用療法(ACT)パートナー薬剤耐性の兆候はなく,東から西へのACT耐性Pfalciparumの伝播の証拠はない。まだACT耐性のグローバル広がりを防ぐ機会の窓がある。タイ科学研究および革新,イニシアティブ5%,フランス,Wellcome Trust.Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝子型 ,  *抗マラリア薬 ,  *マラリア ,  臨床試験 ,  対立遺伝子 ,  併用療法 ,  Plasmodium falciparum ,  遺伝子頻度 ,  遺伝子増幅 ,  ハプロタイプ ,  多剤耐性 ,  一塩基多型 ,  マイクロサテライト ,  窒素複素環化合物 ,  有機フッ素化合物 ,  芳香族縮合化合物 ,  第二アルコール ,  脂環式化合物 ,  ラクトン ,  架橋化合物

分類 (4件)： 感染症・寄生虫症一般  (GD01010H) ,  微生物感染の生理と病原性  (EG03053T) ,  抗原虫薬・駆虫薬の基礎研究  (GW17080G) ,  微生物形態学・分類学  (EG03030Y)

物質索引 (2件)： メフロキン ,  アルテミシニン

タイトルに関連する用語 (6件)： 地域 ,  抗マラリア薬 ,  耐性 ,  分子疫学 ,  観察 ,  研究