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J-GLOBAL ID：202002244660452997   整理番号：20A0716168

実験的脳内出血後の脳損傷を軽減するチップのAAV/BBB媒介遺伝子導入【JST・京大機械翻訳】

AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

著者 (31件)： Zhang Shuo (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Shuo (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Shuo (Academy of Medical Sciences of Zhengzhou University Translational Medicine platform, Zhengzhou, Henan, China) ,  Hu Zheng-wei (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Hu Zheng-wei (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Hu Zheng-wei (Academy of Medical Sciences of Zhengzhou University Translational Medicine platform, Zhengzhou, Henan, China) ,  Luo Hai-yang (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Luo Hai-yang (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Mao Cheng-yuan (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Mao Cheng-yuan (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Tang Mi-bo (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Tang Mi-bo (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Li Yu-sheng (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Li Yu-sheng (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Song Bo (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Song Bo (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Wang Yao-he (National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Zhong-xian (National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Qi-meng (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Qi-meng (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Fan Li-yuan (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Fan Li-yuan (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Fan Li-yuan (Academy of Medical Sciences of Zhengzhou University Translational Medicine platform, Zhengzhou, Henan, China) ,  Zhang Yao (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Zhang Yao (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Yu Wen-kai (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Yu Wen-kai (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Shi Chang-he (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Shi Chang-he (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Xu Yu-ming (Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China) ,  Xu Yu-ming (Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China)
資料名： Translational Stroke Research  (Translational Stroke Research)
巻： 11  号： 2  ページ： 296-309  発行年： 2020年 
JST資料番号： W5000A  ISSN： 1868-601X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 細胞死は脳内出血(ICH)後の二次脳損傷の特徴である。E3リガーゼCHIPは,ICH後の細胞死の重要な機構を仲介する重要な役割を果たすことが報告されている。しかしながら,現在,ICHにおけるCHIPの機能を支持する証拠はない。本研究では,CHIPがICH後の脳損傷において重要な役割を果たすかどうかを決定することを目的とした。著者らの知見は,CHIP発現がICHのラットモデルにおいて血液周囲領域で増加することを示した。AAV/BBBウイルスプラットフォームは,標的遺伝子の非侵襲的,広範で持続的な大域的神経発現を可能にする。AAV/BB-CHIPによる治療は脳損傷を改善し,ICH後の野生型(WT)ラットにおける神経壊死と炎症を阻害した。さらに,CHIP欠損ラットは重度の脳損傷を経験し,それらのWT対応物に対して神経壊死症と炎症のレベルを増加させた。しかしながら,AAV/BB-CHIPによる治療は,ICH後のCHIP欠損の効果を減弱した。まとめると,著者らの結果は,CHIPがICH後の壊死症と病理学的炎症を阻害し,CHIPの過剰発現がICHの治療的介入を表す可能性があることを示す。さらに,AAV/BBBウイルスプラットフォームは,脳損傷の治療のための新しい道を提供する可能性がある。Copyright Springer Science+Business Media, LLC, part of Springer Nature 2019 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 壊死 ,  野生型 ,  炎症 ,  細胞死 ,  *脳損傷 ,  *遺伝子導入 ,  ラット ,  *脳出血
準シソーラス用語： 過剰発現 ,  非侵襲 ,  標的遺伝子 ,  CHIP , 【Automatic Indexing@JST】

著者キーワード (5件)： チップ ,  壊死症 ,  AAV/BBBウイルス ,  脳内出血 ,  ラットモデル

分類 (1件)： 神経の基礎医学  (GN01020W)

タイトルに関連する用語 (5件)： 実験 ,  脳内出血 ,  脳損傷 ,  AAV ,  遺伝子導入